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Fructus gardeniae ameliorates anxiety-like behaviors induced by sleep deprivation via regulating hippocampal metabolomics and gut microbiota.
Liu D, Wang Q, Li Y, Yuan Z, Liu Z, Guo J, Li X, Zhang W, Tao Y, Mei J. Liu D, et al. Front Cell Infect Microbiol. 2023 Jun 12;13:1167312. doi: 10.3389/fcimb.2023.1167312. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 37377643 Free PMC article.
This study aimed to investigate the effects and mechanisms of FG on sleep deprivation (SD)-induced anxiety-like behavior in rats. A model of SD-induced anxiety-like behavior in rats was established by intraperitoneal injection of p-chlorophenylalanine (PCPA). ...In …
This study aimed to investigate the effects and mechanisms of FG on sleep deprivation (SD)-induced anxiety-like behavior in rats. A m …
Gastroparesis and lipid metabolism-associated dysbiosis in Wistar-Kyoto rats.
Dalziel JE, Fraser K, Young W, McKenzie CM, Bassett SA, Roy NC. Dalziel JE, et al. Am J Physiol Gastrointest Liver Physiol. 2017 Jul 1;313(1):G62-G72. doi: 10.1152/ajpgi.00008.2017. Epub 2017 Apr 13. Am J Physiol Gastrointest Liver Physiol. 2017. PMID: 28408641 Free PMC article.
Diglycerides, triglycerides, phosphatidyl-ethanolamines, and phosphatidylserine were lower in WKY rats, whereas cholesterol esters and taurocholic acids were higher. ...
Diglycerides, triglycerides, phosphatidyl-ethanolamines, and phosphatidylserine were lower in WKY rats, whereas cholesterol esters an …
Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress.
Hellhammer J, Fries E, Buss C, Engert V, Tuch A, Rutenberg D, Hellhammer D. Hellhammer J, et al. Stress. 2004 Jun;7(2):119-26. doi: 10.1080/10253890410001728379. Stress. 2004. PMID: 15512856 Clinical Trial.
Phosphatidylserine, derived from cow brains, has been shown previously to dampen the ACTH and cortisol response to physical stress. ...In this study, we investigated the effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) supplementation o …
Phosphatidylserine, derived from cow brains, has been shown previously to dampen the ACTH and cortisol response to physical stress. . …
Luteolin alleviates depression-like behavior by modulating glycerophospholipid metabolism in the hippocampus and prefrontal cortex of LOD rats.
Wu X, Xu H, Zeng N, Li H, Yao G, Liu K, Yan C, Wu L. Wu X, et al. CNS Neurosci Ther. 2024 Mar;30(3):e14455. doi: 10.1111/cns.14455. Epub 2023 Sep 16. CNS Neurosci Ther. 2024. PMID: 37715585 Free PMC article.
RESULTS: The behavioral results of our study demonstrate that LUT significantly ameliorated anxiety and depression-like behaviors while enhancing cognitive function in LOD rats. ...Molecular docking analysis indicated that LUT had strong binding activity with phosphatid …
RESULTS: The behavioral results of our study demonstrate that LUT significantly ameliorated anxiety and depression-like behaviors whi …
A review of nutrients and botanicals in the integrative management of cognitive dysfunction.
Kidd PM. Kidd PM. Altern Med Rev. 1999 Jun;4(3):144-61. Altern Med Rev. 1999. PMID: 10383479 Review.
Whereas, allopathic treatment options are highly limited, nutritional and botanical therapies are available which have proven degrees of efficacy and generally favorable benefit-to-risk profiles. This review covers five such therapies: phosphatidylserine (PS), acetyl-l-car …
Whereas, allopathic treatment options are highly limited, nutritional and botanical therapies are available which have proven degrees of eff …
Atp8a1 deficiency is associated with phosphatidylserine externalization in hippocampus and delayed hippocampus-dependent learning.
Levano K, Punia V, Raghunath M, Debata PR, Curcio GM, Mogha A, Purkayastha S, McCloskey D, Fata J, Banerjee P. Levano K, et al. J Neurochem. 2012 Jan;120(2):302-13. doi: 10.1111/j.1471-4159.2011.07543.x. Epub 2011 Dec 2. J Neurochem. 2012. PMID: 22007859 Free PMC article.
The molecule responsible for the enzyme activity plasma membrane (PM) aminophospholipid translocase (APLT), which catalyzes phosphatidylserine (PS) translocation from the outer to the inner leaflet of the plasma membrane, is unknown in mammals. ...Although their hippocampi …
The molecule responsible for the enzyme activity plasma membrane (PM) aminophospholipid translocase (APLT), which catalyzes phosphatidyls …
SERINC2 increases the risk of bipolar disorder in the Chinese population.
Yang D, Chen J, Cheng X, Cao B, Chang H, Li X, Yang C, Wu Q, Sun J, Manry D, Pan Y, Dong Y, Li J, Xu T, Cao L. Yang D, et al. Depress Anxiety. 2021 Sep;38(9):985-995. doi: 10.1002/da.23186. Epub 2021 Jul 19. Depress Anxiety. 2021. PMID: 34288243
By large-scale sequencing we identified a novel recessive BD risk gene, SERINC2, which plays a role in synthesis of sphingolipid and phosphatidylserine (PS). MRI image results show the homozygous nonsense variant in SERINC2 affects the volume of white matter in cerebellum. …
By large-scale sequencing we identified a novel recessive BD risk gene, SERINC2, which plays a role in synthesis of sphingolipid and phos …
The increment of annexin V-positive microvesicles versus annexin V-negative microvesicles in CSF of an animal model of Alzheimer's disease.
Karimi-Zandi L, Ghorbandaiepour T, Zahmatkesh M. Karimi-Zandi L, et al. Neurosci Lett. 2023 Sep 25;814:137446. doi: 10.1016/j.neulet.2023.137446. Epub 2023 Aug 16. Neurosci Lett. 2023. PMID: 37595881
Alterations in the tissue redox status in pathological conditions, such as Alzheimer's disease (AD), facilitate the translocation of cell membrane phosphatidylserine to the outer leaflet and lead to the MVs shedding. Annexin V binds with high affinity to phosphatidylser …
Alterations in the tissue redox status in pathological conditions, such as Alzheimer's disease (AD), facilitate the translocation of cell me …
Label-free lipidome study of paraventricular thalamic nucleus (PVT) of rat brain with post-traumatic stress injury by Raman imaging.
Chaichi A , Hasan SMA , Mehta N , Donnarumma F , Ebenezer P , Murray KK , Francis J , Gartia MR . Chaichi A , et al. Analyst. 2021 Jan 4;146(1):170-183. doi: 10.1039/d0an01615b. Analyst. 2021. PMID: 33135036
Post-traumatic stress disorder (PTSD) is a widespread psychiatric injury that develops serious life-threatening symptoms like substance abuse, severe depression, cognitive impairments, and persistent anxiety. However, the mechanisms of post-traumatic stress injury in brain …
Post-traumatic stress disorder (PTSD) is a widespread psychiatric injury that develops serious life-threatening symptoms like substance abus …
TSPO ligand residence time influences human glioblastoma multiforme cell death/life balance.
Costa B, Da Pozzo E, Giacomelli C, Taliani S, Bendinelli S, Barresi E, Da Settimo F, Martini C. Costa B, et al. Apoptosis. 2015 Mar;20(3):383-98. doi: 10.1007/s10495-014-1063-3. Apoptosis. 2015. PMID: 25413799
During cell culture treatments, several dynamic events were observed: (a) early apoptotic markers appeared, such as mitochondrial membrane potential collapse (at 3 h) and externalization of phosphatidylserine (at 6 h); (b) cell viability was reduced (at 6 h), without cell …
During cell culture treatments, several dynamic events were observed: (a) early apoptotic markers appeared, such as mitochondrial membrane p …
18 results