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Development and Characterization of Curcumin Loaded Silver Nanoparticle Hydrogels for Antibacterial and Drug Delivery Applications

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Abstract

The present work involves the development of curcumin loaded silver hydrogel nanocomposites based on acrylamide and 2-acrylamido-2-methyl propanesulfonic acid, as a template by redox co-polymerization in the presence of hydrophilic crosslinker N,N 1-methylenebisacrylamide. Silver nitrate was taken as the metal precursor and sodium borohydride as a reducing agent. The formation of silver nanoparticles was monitored using UV–Vis absorption spectroscopy. The developed hydrogel silver nanocomposites (HSNC) were characterized by FTIR, UV–Vis, thermogravimetric analysis, scanning electron microscopy and transmission electron microscopy. The curcumin loading and release characteristics were performed for different hydrogel systems. The developed HSNCs were evaluated for preliminary antibacterial applications.

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Acknowledgments

The authors (SR & KMR) thanks the University Grants Commission (UGC-SAP), Government of India, New Delhi for the partial financial support and AFM-B thanks the University of Johannesburg, South Africa for the partial financial support.

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Authors and Affiliations

  1. Department of Chemical Engineering Technology, Faculty of Engineering and the Built Environment, University of Johannesburg, Doornfontein Campus, P.O. Box 17011, Johannesburg, 2028, South Africa

    Sakey Ravindra

  2. Department of Metallurgy, Faculty of Engineering and the Built Environment, University of Johannesburg, P.O. Box 526, Johannesburg, 2028, South Africa

    Antoine F. Mulaba-Bafubiandi & V. Rajinikanth

  3. Synthetic Polymer Laboratory, Department of Polymer Science & Technology, Sri Krishnadevaraya University, Anantapur, 515055, India

    K. Varaprasad & K. Mohana Raju

  4. Department of General, Organic and Biomedical Chemistry, University of Mons, Mons, Belgium

    N. Narayana Reddy

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  1. Sakey Ravindra
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  2. Antoine F. Mulaba-Bafubiandi
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  3. V. Rajinikanth
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  4. K. Varaprasad
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  6. K. Mohana Raju
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Correspondence to Sakey Ravindra.

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Ravindra, S., Mulaba-Bafubiandi, A.F., Rajinikanth, V. et al. Development and Characterization of Curcumin Loaded Silver Nanoparticle Hydrogels for Antibacterial and Drug Delivery Applications. J Inorg Organomet Polym 22, 1254–1262 (2012). https://doi.org/10.1007/s10904-012-9734-4

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  • DOI: https://doi.org/10.1007/s10904-012-9734-4

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