SARS-CoV-2, Covid-19, and the debunking of conspiracy theories
Corresponding Author
Mohamad S. Hakim
Department of Microbiology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia
Center for Child Health—PRO, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia
Correspondence
Mohamad S. Hakim, Department of Microbiology, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada, 55281 Yogyakarta, Indonesia.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Mohamad S. Hakim
Department of Microbiology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia
Center for Child Health—PRO, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia
Correspondence
Mohamad S. Hakim, Department of Microbiology, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada, 55281 Yogyakarta, Indonesia.
Email: [email protected]
Search for more papers by this authorSummary
The emergence of a novel human coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has engaged considerable awareness and attention around the world. The associated disease, coronavirus disease 2019 (Covid-19), has now involved virtually all 200 countries. The total number of confirmed cases has been much more than in the two previous outbreaks of human coronaviruses, that is, SARS-CoV and Middle East respiratory syndrome coronavirus. In line with the outbreak escalation, false information about SARS-CoV-2 and its associated disease disseminated globally, particularly through online and social media. Believers in conspiracy theories promote misinformation that the virus is not contagious, is the result of laboratory manipulation or is created to gain profit by distributing new vaccines. The most dangerous effect of this widely disseminated misinformation is it will negatively influence the attitudes and behaviours for preventive measures to contain the outbreak. In this review, I discuss common conspiracy theories associated with SARS-CoV-2 and Covid-19 and consider how we can address and counterbalance these issues based on scientific information and studies.
CONFLICT OF INTEREST
The author declares no conflict of interest.
REFERENCES
- 1Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020; 382(8): 727-733.
- 2Zhou P, Yang XL, Wang XG, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020; 579(7798): 270-273.
- 3 Coronaviridae Study Group of the International Committee on Taxonomy of Viruses. The species severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nat Microbiol. 2020; 5(4): 536-544.
- 4Alonso-Galban P, Alemany-Castilla C. Curbing misinformation and disinformation in the Covid-19 era: a view from Cuba. MEDICC Rev. 2020; 22(2): 45-46.
- 5Cuan-Baltazar JY, Munoz-Perez MJ, Robledo-Vega C, Perez-Zepeda MF, Soto-Vega E. Misinformation of Covid-19 on the internet: infodemiology study. JMIR Public Health Surveill. 2020; 6(2):e18444.
- 6Kouzy R, Abi Jaoude J, Kraitem A, et al. Coronavirus goes viral: quantifying the Covid-19 misinformation epidemic on Twitter. Cureus. 2020; 12(3):e7255.
- 7Ippolito G, Hui DS, Ntoumi F, Maeurer M, Zumla A. Toning down the 2019-nCoV media hype-and restoring hope. Lancet Respir Med. 2020; 8(3): 230-231.
- 8Gralinski LE, Menachery VD. Return of the coronavirus: 2019-nCoV. Viruses. 2020; 12(2): 135.
- 9Kata A. A postmodern Pandora's box: anti-vaccination misinformation on the internet. Vaccine. 2010; 28(7): 1709-1716.
- 10Kata A. Anti-vaccine activists, Web 2.0, and the postmodern paradigm-an overview of tactics and tropes used online by the anti-vaccination movement. Vaccine. 2012; 30(25): 3778-3789.
- 11Bora K, Das D, Barman B, Borah P. Are internet videos useful sources of information during global public health emergencies? A case study of YouTube videos during the 2015-16 Zika virus pandemic. Pathog Glob Health. 2018; 112(6): 320-328.
- 12D'Souza RS, D'Souza S, Strand N, Anderson A, Vogt MNP, Olatoye O. YouTube as a source of medical information on the novel coronavirus 2019 disease (Covid-19) pandemic. Global Publ Health. 2020; 15(7): 935-942.
- 13Li HO, Bailey A, Huynh D, Chan J. YouTube as a source of information on Covid-19: a pandemic of misinformation? BMJ Glob Health. 2020; 5(5):e002604.
- 14Dredze M, Broniatowski DA, Hilyard KM. Zika vaccine misconceptions: a social media analysis. Vaccine. 2016; 34(30): 3441-3442.
- 15Dredze M, Broniatowski DA, Smith MC, Hilyard KM. Understanding vaccine refusal: why we need social media now. Am J Prev Med. 2016; 50(4): 550-552.
- 16Hoffman BL, Felter EM, Chu KH, et al. It's not all about autism: the emerging landscape of anti-vaccination sentiment on Facebook. Vaccine. 2019; 37(16): 2216-2223.
- 17Mian A, Khan S. Coronavirus: the spread of misinformation. BMC Med. 2020; 18(1): 89.
- 18Jamison AM, Broniatowski DA, Dredze M, Wood-Doughty Z, Khan D, Quinn SC. Vaccine-related advertising in the Facebook Ad Archive. Vaccine. 2020; 38(3): 512-520.
- 19Megget K. Even Covid-19 can't kill the anti-vaccination movement. BMJ. 2020; 369:m2184.
- 20Jaiswal J, Halkitis PN. Towards a more inclusive and dynamic understanding of medical mistrust informed by science. Behav Med. 2019; 45(2): 79-85.
- 21Goncalves-Sa J. The fight against the new coronavirus outbreak, we must also struggle with human bias. Nat Med. 2020; 26(3): 305.
- 22Andersen KG, Rambaut A, Lipkin WI, Holmes EC, Garry RF. The proximal origin of SARS-CoV-2. Nat Med. 2020; 26(4): 450-452.
- 23Liu SL, Saif LJ, Weiss SR, Su L. No credible evidence supporting claims of the laboratory engineering of SARS-CoV-2. Emerg Microb Infect. 2020; 9(1): 505-507.
- 24Hao P, Zhong W, Song S, Fan S, Li X. Is SARS-CoV-2 originated from laboratory? A rebuttal to the claim of formation via laboratory recombination. Emerg Microb Infect. 2020; 9(1): 545-547.
- 25Gonsalves G, Staley P. Panic, paranoia, and public health-the AIDS epidemic's lessons for Ebola. N Engl J Med. 2014; 371(25): 2348-2349.
- 26Bridgen A. Introduction. In: A Bridgen, ed. Reverse genetics of RNA viruses: applications and perspectives. Germany: John Wiley & Sons; 2012.
10.1002/9781118405338.ch1 Google Scholar
- 27Gao P, Ma S, Lu D, Mitcham C, Jing Y, Wang G. Prudently conduct the engineering and synthesis of the SARS-CoV-2 virus. Synth Syst Biotechnol. 2020; 5(2): 59-61.
- 28Casadevall A, Imperiale MJ. Risks and benefits of gain-of-function experiments with pathogens of pandemic potential, such as influenza virus: a call for a science-based discussion. mBio. 2014; 5(4):e01730-14.
- 29Walpita P, Flick R. Reverse genetics of negative-stranded RNA viruses: a global perspective. FEMS Microbiol Lett. 2005; 244(1): 9-18.
- 30Racaniello VR, Baltimore D. Cloned poliovirus complementary DNA is infectious in mammalian cells. Science. 1981; 214(4523): 916-919.
- 31Schnell MJ, Mebatsion T, Conzelmann KK. Infectious rabies viruses from cloned cDNA. EMBO J. 1994; 13(18): 4195-4203.
- 32Bridgen A, Elliott RM. Rescue of a segmented negative-strand RNA virus entirely from cloned complementary DNAs. Proc Natl Acad Sci U. S. A. 1996; 93(26): 15400-15404.
- 33Fodor E, Devenish L, Engelhardt OG, Palese P, Brownlee GG, Garcia-Sastre A. Rescue of influenza A virus from recombinant DNA. J Virol. 1999; 73(11): 9679-9682.
- 34Hoffmann E, Mahmood K, Yang CF, Webster RG, Greenberg HB, Kemble G. Rescue of influenza B virus from eight plasmids. Proc Natl Acad Sci U. S. A. 2002; 99(17): 11411-11416.
- 35Jackson D, Cadman A, Zurcher T, Barclay WS. A reverse genetics approach for recovery of recombinant influenza B viruses entirely from cDNA. J Virol. 2002; 76(22): 11744-11747.
- 36Herfst S, Schrauwen EJ, Linster M, et al. Airborne transmission of influenza A/H5N1 virus between ferrets. Science. 2012; 336(6088): 1534-1541.
- 37Imai M, Watanabe T, Hatta M, et al. Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets. Nature. 2012; 486(7403): 420-428.
- 38Schrauwen EJ, Herfst S, Chutinimitkul S, et al. Possible increased pathogenicity of pandemic (H1N1) 2009 influenza virus upon reassortment. Emerg Infect Dis. 2011; 17(2): 200-208.
- 39Zhang W, Xue T, Wu X, et al. Increase in viral yield in eggs and MDCK cells of reassortant H5N1 vaccine candidate viruses caused by insertion of 38 amino acids into the NA stalk. Vaccine. 2011; 29(45): 8032-8041.
- 40Taubenberger JK, Reid AH, Lourens RM, Wang R, Jin G, Fanning TG. Characterization of the 1918 influenza virus polymerase genes. Nature. 2005; 437(7060): 889-893.
- 41Tumpey TM, Basler CF, Aguilar PV, et al. Characterization of the reconstructed 1918 Spanish influenza pandemic virus. Science. 2005; 310(5745): 77-80.
- 42Johnson BA, Graham RL, Menachery VD. Viral metagenomics, protein structure, and reverse genetics: key strategies for investigating coronaviruses. Virology. 2018; 517: 30-37.
- 43Almazan F, Sola I, Zuniga S, et al. Coronavirus reverse genetic systems: infectious clones and replicons. Virus Res. 2014; 189: 262-270.
- 44Almazan F, Gonzalez JM, Penzes Z, et al. Engineering the largest RNA virus genome as an infectious bacterial artificial chromosome. Proc Natl Acad Sci U. S. A. 2000; 97(10): 5516-5521.
- 45Yount B, Curtis KM, Baric RS. Strategy for systematic assembly of large RNA and DNA genomes: transmissible gastroenteritis virus model. J Virol. 2000; 74(22): 10600-10611.
- 46Beall A, Yount B, Lin CM, et al. Characterization of a pathogenic full-Length cDNA clone and transmission model for porcine epidemic diarrhea virus strain PC22A. mBio. 2016; 7(1):e01451-15.
- 47Thiel V, Herold J, Schelle B, Siddell SG. Infectious RNA transcribed in vitro from a cDNA copy of the human coronavirus genome cloned in vaccinia virus. J Gen Virol. 2001; 82(Pt 6): 1273-1281.
- 48Almazan F, Dediego ML, Galan C, et al. Construction of a severe acute respiratory syndrome coronavirus infectious cDNA clone and a replicon to study coronavirus RNA synthesis. J Virol. 2006; 80(21): 10900-10906.
- 49Yount B, Curtis KM, Fritz EA, et al. Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus. Proc Natl Acad Sci U. S. A. 2003; 100(22): 12995-13000.
- 50Scobey T, Yount BL, Sims AC, et al. Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus. Proc Natl Acad Sci U. S. A. 2013; 110(40): 16157-16162.
- 51Thi Nhu Thao T, Labroussaa F, Ebert N, et al. Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform. Nature. 2020; 582(7813): 561-565.
- 52Ye C, Chiem K, Park JG, et al. Rescue of SARS-CoV-2 from a single bacterial artificial chromosome. mBio. 2020; 11(5):e02168-20.
- 53Screaton G, Mongkolsapaya J, Yacoub S, Roberts C. New insights into the immunopathology and control of dengue virus infection. Nat Rev Immunol. 2015; 15(12): 745-759.
- 54Roberts A, Deming D, Paddock CD, et al. A mouse-adapted SARS-coronavirus causes disease and mortality in BALB/c mice. PLoS Pathog. 2007; 3(1):e5.
- 55Menachery VD, Yount BL, Jr., Debbink K, et al. A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence. Nat Med. 2015; 21(12): 1508-1513.
- 56Menachery VD, Yount BL, Jr., Sims AC, et al. SARS-like WIV1-CoV poised for human emergence. Proc Natl Acad Sci U. S. A. 2016; 113(11): 3048-3053.
- 57Cui J, Li F, Shi ZL. Origin and evolution of pathogenic coronaviruses. Nat Rev Microbiol. 2019; 17(3): 181-192.
- 58Padhi AK, Tripathi T. Can SARS-CoV-2 accumulate mutations in the S-protein to increase pathogenicity? ACS Pharmacol Transl Sci. 2020; 3(5): 1023-1026.
- 59Heald-Sargent T, Gallagher T. Ready, set, fuse! the coronavirus spike protein and acquisition of fusion competence. Viruses. 2012; 4(4): 557-580.
- 60Lu R, Zhao X, Li J, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020; 395(10224): 565-574.
- 61Wan Y, Shang J, Graham R, Baric RS, Li F. Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS coronavirus. J Virol. 2020; 94(7):e00127-20.
- 62Bertram S, Glowacka I, Steffen I, Kuhl A, Pohlmann S. Novel insights into proteolytic cleavage of influenza virus hemagglutinin. Rev Med Virol. 2010; 20(5): 298-310.
- 63Wang Q, Qiu Y, Li JY, Zhou ZJ, Liao CH, Ge XY. A unique protease cleavage site predicted in the spike protein of the novel pneumonia coronavirus (2019-nCoV) potentially related to viral transmissibility. Virol Sin. 2020; 35(3): 337-339.
- 64Menachery VD, Dinnon KH, Yount BL, Jr., et al. Trypsin treatment unlocks barrier for zoonotic bat coronavirus infection. J Virol. 2020; 94(5):e01774-19.
- 65Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020; 181(2): 271-280.e8.
- 66Matsuyama S, Nao N, Shirato K, et al. Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells. Proc Natl Acad Sci U. S. A. 2020; 117(13): 7001-7003.
- 67Hoffmann M, Hofmann-Winkler H, Smith JC, et al. Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity. bioRxiv. 2020. https://doi.org/10.1101/2020.08.05.237651.
10.1101/2020.08.05.237651 Google Scholar
- 68Zhou H, Chen X, Hu T, et al. A novel bat coronavirus closely related to SARS-CoV-2 contains natural insertions at the S1/S2 cleavage site of the spike protein. Curr Biol. 2020; 30(11): 2196-2203.e3.
- 69Zhang T, Wu Q, Zhang Z. Probable pangolin origin of SARS-CoV-2 associated with the Covid-19 outbreak. Curr Biol. 2020; 30(8): 1578.
- 70Shang J, Ye G, Shi K, et al. Structural basis of receptor recognition by SARS-CoV-2. Nature. 2020; 581(7807): 221-224.
- 71Lam TT, Jia N, Zhang YW, et al. Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins. Nature. 2020; 583(7815): 282-285.
- 72Li X, Giorgi EE, Marichannegowda MH, et al. Emergence of SARS-CoV-2 through recombination and strong purifying selection. Sci Adv. 2020; 6(27):eabb9153.
- 73Ito T, Goto H, Yamamoto E, et al. Generation of a highly pathogenic avian influenza A virus from an avirulent field isolate by passaging in chickens. J Virol. 2001; 75(9): 4439-4443.
- 74Steinhauer DA. Role of hemagglutinin cleavage for the pathogenicity of influenza virus. Virology. 1999; 258(1): 1-20.
- 75Wang Q, Zhang Y, Wu L, et al. Structural and functional basis of SARS-CoV-2 entry by using human ACE2. Cell. 2020; 181(4): 894-904.e9.
- 76Wrapp D, Wang N, Corbett KS, et al. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science. 2020; 367(6483): 1260-1263.
- 77 Centers for Disease Control and Prevention. CDC lab determines possible Anthrax exposures: staff provided antibiotics/monitoring. https://www.cdc.gov/media/releases/2014/s0619-anthrax.html. 2014. Accessed October 10, 2020.
- 78 Centers for Disease Control and Prevention. Report on the inadvertent cross-contamination and shipment of a laboratory specimen with influenza virus H5N1. https://www.cdc.gov/labs/pdf/InvestigationCDCH5N1contaminationeventAugust15.pdf. 2014.
- 79McCollum AM, Austin C, Nawrocki J, et al. Investigation of the first laboratory-acquired human cowpox virus infection in the United States. J Infect Dis. 2012; 206(1): 63-68.
- 80Nakajima K, Desselberger U, Palese P. Recent human influenza A (H1N1) viruses are closely related genetically to strains isolated in 1950. Nature. 1978; 274(5669): 334-339.
- 81Webster RG, Bean WJ, Gorman OT, Chambers TM, Kawaoka Y. Evolution and ecology of influenza A viruses. Microbiol Rev. 1992; 56(1): 152-179.
- 82Xia H, Huang Y, Ma H, et al. Biosafety level 4 laboratory user training program, China. Emerg Infect Dis. 2019; 25(5):e180220.
- 83Lim PL, Kurup A, Gopalakrishna G, et al. Laboratory-acquired severe acute respiratory syndrome. N Engl J Med. 2004; 350(17): 1740-1745.
- 84Orellana C. Laboratory-acquired SARS raises worries on biosafety. Lancet Infect Dis. 2004; 4(2): 64.
- 85Normile D. Mounting lab accidents raise SARS fears. Science. 2004; 304(5671): 659-661.
- 86Hu B, Zeng LP, Yang XL, et al. Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus. PLoS Pathog. 2017; 13(11):e1006698.
- 87Latinne A, Hu B, Olival KJ, et al. Origin and cross-species transmission of bat coronaviruses in China. Nat Commun. 2020; 11(1): 4235.
- 88Lin XD, Wang W, Hao ZY, et al. Extensive diversity of coronaviruses in bats from China. Virology. 2017; 507: 1-10.
- 89Ge XY, Wang N, Zhang W, et al. Coexistence of multiple coronaviruses in several bat colonies in an abandoned mineshaft. Virol Sin. 2016; 31(1): 31-40.
- 90Luo Y, Li B, Jiang RD, et al. Longitudinal surveillance of betacoronaviruses in fruit bats in Yunnan Province, China during 2009-2016. Virol Sin. 2018; 33(1): 87-95.
- 91Xu L, Zhang F, Yang W, et al. Detection and characterization of diverse alpha- and betacoronaviruses from bats in China. Virol Sin. 2016; 31(1): 69-77.
- 92 The biggest mystery: what it will take to trace the coronavirus source. https://www.nature.com/articles/d41586-020-01541-z. 2020. Accessed October 28, 2020.
- 93Shanker AK. The possible origins of the novel coronavirus SARS-CoV-2. OSF Preprints; 2020.
- 94 The case is building that Covid-19 had a lab origin. https://www.independentsciencenews.org/health/the-case-is-building-that-covid-19-had-a-lab-origin/. 2020. Accessed October 28, 2020.
- 95Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020; 395(10223): 497-506.
- 96Morens DM, Breman JG, Calisher CH, et al. The origin of Covid-19 and why it matters. Am J Trop Med Hyg. 2020; 103(3): 955-959.
- 97Schmidt AL, Zollo F, Scala A, Betsch C, Quattrociocchi W. Polarization of the vaccination debate on Facebook. Vaccine. 2018; 36(25): 3606-3612.
- 98Jolley D, Douglas KM. The effects of anti-vaccine conspiracy theories on vaccination intentions. PLoS One. 2014; 9(2):e89177.
- 99de Wit E, van Doremalen N, Falzarano D, Munster VJ. SARS and MERS: recent insights into emerging coronaviruses. Nat Rev Microbiol. 2016; 14(8): 523-534.
- 100 List of candidate vaccines developed against SARS-CoV. https://www.who.int/blueprint/priority-diseases/key-action/list-of-candidate-vaccines-developed-against-sars.pdf. 2020. Accessed December 25, 2020.
- 101Munster VJ, Koopmans M, van Doremalen N, van Riel D, de Wit E. A novel coronavirus emerging in China - key questions for impact assessment. N Engl J Med. 2020; 382(8): 692-694.
- 102Roper RL, Rehm KE. SARS vaccines: where are we? Expert Rev Vaccines. 2009; 8(7): 887-898.
- 103 Coronavirus: Institut Pasteur warns against false information circulating on social media. https://www.pasteur.fr/en/coronavirus-institut-pasteur-warns-against-false-information-circulating-social-media. 2020. Accessed December 25, 2020.
- 104 List of candidate vaccines developed against MERS-CoV. https://www.who.int/docs/default-source/blue-print/classes-of-candidate-vaccines-against-mers-cov.pdf. 2020. Accessed December 25, 2020.
- 105Wilder-Smith A, Chiew CJ, Lee VJ. Can we contain the Covid-19 outbreak with the same measures as for SARS? Lancet Infect Dis. 2020; 20(5):e102-e7.
- 106 We're not ready for the next epidemic. https://www.gatesnotes.com/Health/We-Are-Not-Ready-for-the-Next-Epidemic. 2020. Accessed December 25, 2020.
- 107Fan Y, Zhao K, Shi ZL, Zhou P. Bat coronaviruses in China. Viruses. 2019; 11(3): 210.
- 108TED Ideas worth spreading. https://www.ted.com/talks/larry_brilliant_my_wish_help_me_stop_pandemics. 2020. Accessed December 25, 2020.
- 109Wang LF, Shi Z, Zhang S, Field H, Daszak P, Eaton BT. Review of bats and SARS. Emerg Infect Dis. 2006; 12(12): 1834-1840.
- 110 World Health Organization (WHO). Ten threats to global health in 2019. https://www.who.int/news-room/spotlight/ten-threats-to-global-health-in-2019. 2020. Accessed December 25, 2020.
- 111 A COVID-19 vaccine might be ready within 18 months. But what happens then? https://www.gatesfoundation.org/TheOptimist/Articles/coronavirus-vaccine-development-gavi. 2020. Accessed December 25, 2020.
- 112Ball P, Maxmen A. The epic battle against coronavirus misinformation and conspiracy theories. Nature. 2020; 581(7809): 371-374.
- 113Gouglas D, Christodoulou M, Plotkin SA, Hatchett R. CEPI: driving progress toward epidemic preparedness and response. Epidemiol Rev. 2019; 41(1): 28-33.
- 114Jeyanathan M, Afkhami S, Smaill F, Miller MS, Lichty BD, Xing Z. Immunological considerations for Covid-19 vaccine strategies. Nat Rev Immunol. 2020; 20(10): 615-632.
- 115https://www.reddit.com/r/Coronavirus/comments/fksnbf/im_bill_gates_cochair_of_the_bill_melinda_gates/?sort=qa. 2020. Accessed December 25, 2020.
- 116 Bill Gates will use microchip implants to fight coronavirus. https://biohackinfo.com/news-bill-gates-id2020-vaccine-implant-covid-19-digital-certificates/. 2020. Accessed December 25, 2020.
- 117Quinn SC, Kumar S, Freimuth VS, Kidwell K, Musa D. Public willingness to take a vaccine or drug under emergency use authorization during the 2009 H1N1 pandemic. Biosecur Bioterror. 2009; 7(3): 275-290.
- 118Jiang S. Don't rush to deploy Covid-19 vaccines and drugs without sufficient safety guarantees. Nature. 2020; 579(7799): 321.
- 119Bogart LM, Thorburn S. Are HIV/AIDS conspiracy beliefs a barrier to HIV prevention among African Americans? J Acquir Immune Defic Syndr. 2005; 38(2): 213-218.
- 120Klonoff EA, Landrine H. Do blacks believe that HIV/AIDS is a government conspiracy against them? Prev Med. 1999; 28(5): 451-457.
- 121Ross MW, Essien EJ, Torres I. Conspiracy beliefs about the origin of HIV/AIDS in four racial/ethnic groups. J Acquir Immune Defic Syndr. 2006; 41(3): 342-344.
- 122Pradhan P, Pandey AK, Mishra A, et al. Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag. bioRxiv. 2020. https://doi.org/10.1101/2020.01.30.927871.
10.1101/2020.01.30.927871 Google Scholar
- 123Xiao C, Li X, Liu S, Sang Y, Gao SJ, Gao F. HIV-1 did not contribute to the 2019-nCoV genome. Emerg Microb Infect. 2020; 9(1): 378-381.
- 124Zhang C, Zheng W, Huang X, Bell EW, Zhou X, Zhang Y. Protein structure and sequence reanalysis of 2019-nCoV genome refutes snakes as its intermediate host and the unique similarity between its spike protein insertions and HIV-1. J Proteome Res. 2020; 19(4): 1351-1360.
- 125Zhang Y, Liu Y, Liu H, Tang WH. Exosomes: biogenesis, biologic function and clinical potential. Cell Biosci 2019; 9: 19.
- 126Ramakrishnaiah V, Thumann C, Fofana I, et al. Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7.5 cells. Proc Natl Acad Sci U. S. A. 2013; 110(32): 13109-13113.
- 127Kogure T, Lin WL, Yan IK, Braconi C, Patel T. Intercellular nanovesicle-mediated microRNA transfer: a mechanism of environmental modulation of hepatocellular cancer cell growth. Hepatology. 2011; 54(4): 1237-1248.
- 128 SARS-CoV-2 is just an exosome—Dr. Andrew Kaufman. https://www.youtube.com/watch?v=OAaJNppVpbM. 2020. Accessed December 25, 2020.
- 129 GISAID. https://www.gisaid.org/. 2020.
- 130Gould SJ, Booth AM, Hildreth JE. The Trojan exosome hypothesis. Proc Natl Acad Sci U. S. A. 2003; 100(19): 10592-10597.
- 131Lasser C. Exosomes in diagnostic and therapeutic applications: biomarker, vaccine and RNA interference delivery vehicle. Expet Opin Biol Ther. 2015; 15(1): 103-117.