An update on the role of testosterone replacement therapy in the management of hypogonadism
Abstract
Prevalence of hypogonadism and associations with comorbidities
How do guidelines help us?
TRT and cardiometabolic risk profile
HbA1c (%) >7.5 | Weight (kg) | BMI (kg/m2) | WC (cm) | TC (mmol/l) | EF (IIEF) | AMS (patients) | HADSD | GEQ (% imp) | |
---|---|---|---|---|---|---|---|---|---|
30 weeks | −0.41 | −0.7 | −0.3 | −2.5 | −0.25 | +3.0 | −5.3 | −1.01 | 46 |
p value | 0.007 | 0.13 | 0.01 | 0.012 | 0.025 | 0.006 | 0.095 | 0.64 | <0.001 |
82 weeks | −0.87 | −2.7 | −1.00 | −4.2 | −0.19 | +4.31 +9.57 PDE5I |
−8.1 | −2.18 | 67–70 |
p value | 0.009 | 0.016 | 0.019 | <0.001 | 0.035 | 0.003 | 0.001 | 0.001 | 0.0001 |
Other benefits of TRT
The important concept of frailty
Positive studies on TRT and cardiovascular safety
Prospective studies
Retrospective studies
Negative studies on TRT and cardiovascular safety
Randomized controlled studies
Retrospective studies
Meta-analyses
Is the formulation of TRT important?
Monitoring and follow up
What does this mean for clinical practice?
Conflict of interest statement
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This article was published in Therapeutic Advances in Urology.
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