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First published July 1997

A Randomized Controlled Trial of Piroxicam in the Management of Acute Ankle Sprain in Australian Regular Army Recruits: The Kapooka Ankle Sprain Study

Mark A. Slatyer, BMedSci, BMed, PhD, FAFPHM, Michael J. Hensley, MBBS, PhD, FRACP, FAFPHM, MRACMA, and Ruth Lopert, BSc, BMedView all authors and affiliations
Volume 25, Issue 4
https://doi.org/10.1177/036354659702500419

Abstract

Three hundred sixty-four Australian Regular Army re cruits with acute ankle sprains sustained during train ing were randomized to treatment with either piroxicam or placebo. Compared with the placebo group, sub jects treated with piroxicam had less pain, were able to resume training more rapidly, were treated at lower cost, and were found to have increased exercise en durance on resumption of activity. Nausea was the only side effect reported significantly more often in the treatment group than in the placebo group (6.8% ver sus 0.3%). Interestingly, subjects treated with piroxi cam showed some evidence of local abnormalities such as instability and reduced range of movement. We conclude that nonsteroidal antiinflammatory agents should form an integral part of the treatment of acute ankle sprains.

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References

Aghababian RV Comparison of diflunisal and acetaminophen with codeine in the management of grade 2 ankle sprain Clin Ther 8 520-526, 1986
Google Scholar
Ali S. Piroxicam in the treatment of acute musculoskeletal disorders. Bangladesh multicentre study Curr Ther Res 32 574-578, 1982
Google Scholar
Andersson S., Fredin H., Lindberg H., et al lbuprofen and compression bandage in the treatment of ankle sprains Acta Orthop Scand 54 322-325, 1983
Google Scholar
Bahamonde LA, Saavedra H. Comparison of the analgesic and antiinflammatory effects of diclofenac potassium versus piroxicam versus placebo in ankle sprain patients. J Int Med Res 18 104-111, 1990 5 Bahamonde LA, Saavedra H. Comparison of the analgesic and antiinflammatory effects of diclofenac potassium versus placebo in ankle sprain patients J Int Med Res 12. 46-50, 1984
Google Scholar
Bosien WR, Staples SO, Russell SW Residual disability following acute ankle sprains J Bone Joint Surg 37A 1237-1243, 1989
Google Scholar
Brostrom L., Sundelin P. Sprained ankles IV Histologic changes in recent and "chronic" ligament ruptures Acta Chir Scand 132 248-253, 1966
Google Scholar
Capell HA, Konetschmk B., Glass RC Anti-inflammatory analgesic drug responders and non-responders A clinico-pharmacological study of flurbiprofen Br J Pharmacol 4 623-624, 1977
Google Scholar
Capello WN The sprained ankle Hosp Med 17 46E-46T, 1981
Google Scholar
Capello WN, Pierce RO Soft tissue injuries to the ankle Am Fam Physician 15 152-155, 1977
Google Scholar
Carty TJ, Eskra JD, Lombardino JG, et al. Piroxicam, a potent inhibitor of prostaglandin production in cell culture structure activity study Prostaglandins 19 51-59, 1980
Google Scholar
Carty TJ, Stevens JS, Lombardino JG, et al- Piroxicam a structurally novel anti-inflammatory compound Mode of prostaglandin synthesis inhibition Prostaglandins 19 671-682, 1980
Google Scholar
Cash HC, Humpston D., Kasap HS Feldene in the symptomatic treatment of primary dysmenorrhoea Practitioner 226. 1338-1341, 1982
Google Scholar
Champion GD Therapeutic usage of the non-steroidal anti-inflammatory drugs Med J Austr 149 203-213, 1988
Google Scholar
Cruess RL Healing bone tendon and ligament, in Rockwood CA, Green DP (eds) Fractures in Adults Philadelphia, JB Lippincott Co, 1984, pp 137-147
Google Scholar
Dahners LE, Gilbert JA, Lester GE, et al The effect of a nonsteroidal antiinflammatory drug on the healing of ligaments Am J Sports Med 16. 641-646, 1988
Google Scholar
Dameron TB Jr Management of the acute ankle sprains South Med J 70 1166-1167, 1977
Google Scholar
Dessam P., Estabrodes TF, Gordon AJ Piroxicam in the treatment of osteoarthritis A multicentre study in general practice involving 1218 patients J Int Med Res 7 335-343, 1979
Google Scholar
Dickinson PH, Curran WP, Orwig JB, et al Complete lateral ligament tears of the ankle surgery or cast ? Contemp Orthop 6(3) 35-40, 1983
Google Scholar
Dupont M., Béliveau P., Theriault G., et al The efficacy of antiinflammatory medication in the treatment of the acutely sprained ankle Am J Sports Med 15 41-45, 1987
Google Scholar
Edeiken J., Cotler JM Ankle injury The need for stress films J Am Med Assoc 240 1182-1184, 1978
Google Scholar
Filho JL Multicenter study of piroxicam in the treatment of acute musculoskeletal diseases involving 3011 patients Eur J Rheumatol Inflamm 6 119-125, 1983
Google Scholar
Fredberg U., Hansen PA, Skinhøj A. lbuprofen in the treatment of acute ankle joint injuries A double-blind study Am J Sports Med 17 564-566, 1989
Google Scholar
Glasgow M., Jackson A., Jamieson AM Instability of the ankle after injury to the lateral ligament J Bone Joint Surg 62B. 196-200, 1980
Google Scholar
Goldie IF, Gunterberg B., Jacobson C. Foot volumetry as an objective test of the effect of antiphlogistic drugs in ankle sprains Rheumatol Rehabil 13. 204-207, 1974
Google Scholar
Hess H. Therapy of acute sports injuries with the oral antirheumatic piroxicam Medizinische Welt 31. 407-409, 1980
Google Scholar
Jaffe GV, et al A controlled study of diflunisal in sprains and strains Curr Med Res Opin 5 584-588, 1978
Google Scholar
Lacey PH, Dodd GD, Shannon DJ A double-blind placebo controlled study of piroxicam in the management of acute musculoskeletal disorders Eur J Rheumatol Inflamm 7. 95-104, 1984
Google Scholar
Lereim P., Gabor I. Piroxicam and naproxen in acute sports injuries Am J Med 84 (Suppl 5A) 45-49, 1988
Google Scholar
Lereim P., Gabor I. Piroxicam In acute musculoskeletal disorders Int Congress Symposium Series 67 41-43, 1983
Google Scholar
Lester AA Management of sprained ankles A double-blind study. Practitioner 225 935-936, 1981
Google Scholar
Lettin AW Diagnosis and treatment of sprained ankle. Br Med J 1. 1056-1060, 1963
Google Scholar
Lockhart WE Management of sprained ankle in athletics Southwest Med 46 344-345, 1965
Google Scholar
Makuloluwe RT, Mouzas GL Ultrasound in the treatment of sprained ankles Practitioner 218 586-588, 1977
Google Scholar
McLatchie GR, Allister C., MacEwen JC, et al Variable schedules of ibuprofen for ankle sprains Br J Sports Med 19. 203-206, 1985
Google Scholar
Moran M. An observer-blind comparison of diclofenac potassium, piroxicam and placebo in the treatment of ankle sprains Curr Med Res Opin 12 268-274, 1990
Google Scholar
Nilsson BE Sprains of the lateral ligaments Part 1 Epidemiological considerations J Oslo City Hosp 32 3-29, 1982
Google Scholar
Percy EC, Hill RD, Callaghan JE The "sprained" ankle J Trauma 9 972-986, 1969
Google Scholar
Santilli G., Tucmmei U., Cannistra FM Comparative study with piroxicam and ibuprofen versus placebo in the supportive treatment of minor sports injuries J Int Med Res 8 265-269, 1980
Google Scholar
Sorboroff SH, Pappius EM, Komaroff AL: Benefits, risks, and cost of alternative approaches to the evaluation and treatment of severe ankle sprain Clin Orthop 183 160-168, 1984
Google Scholar
Twomey TM, Bartolucci SR, Hobbs DC Analysis of piroxicam in plasma by high-performance liquid chromatography J Chromatogr 183 104-108, 1980
Google Scholar
Vegso JJ, Harmon LE III Nonoperative management of athletic ankle injuries Clin Sports Med 1 85-98, 1982
Google Scholar
Viljakka T., Rokkanen P. The treatment of ankle spram by bandaging and antiphlogistic drugs Ann Chir Gynaecol 72 66-70, 1983
Google Scholar
Wiseman ED, Hobbs DC Review of pharmacokinetic studies with piroxicam Am J Med (February 16). 9-17, 1982
Google Scholar

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Published In

Volume 25, Issue 4
Pages: 544 - 553
Article first published: July 1997
Issue published: July 1997

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© 1997.
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PubMed: 9240990

Authors

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Mark A. Slatyer, BMedSci, BMed, PhD, FAFPHM
1st Recruit Training Battalion, Kapooka, and Faculty of Medicine, University of Newcastle, Newcastle, New South Wales, Australia
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Michael J. Hensley, MBBS, PhD, FRACP, FAFPHM, MRACMA
1st Recruit Training Battalion, Kapooka, and Faculty of Medicine, University of Newcastle, Newcastle, New South Wales, Australia
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Ruth Lopert, BSc, BMed
1st Recruit Training Battalion, Kapooka, and Faculty of Medicine, University of Newcastle, Newcastle, New South Wales, Australia
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