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Chemically Cross-Linked Carbon Nanotube Films Engineered to Control Neuronal Signaling

Cite this: ACS Nano 2019, 13, 8, 8879–8889
Publication Date (Web):July 22, 2019
https://doi.org/10.1021/acsnano.9b02429
Copyright © 2019 American Chemical Society
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    Abstract

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    In recent years, the use of free-standing carbon nanotube (CNT) films for neural tissue engineering has attracted tremendous attention. CNT films show large surface area and high electrical conductivity that combined with flexibility and biocompatibility may promote neuron growth and differentiation while stimulating neural activity. In addition, adhesion, survival, and growth of neurons can be modulated through chemical modification of CNTs. Axonal and synaptic signaling can also be positively tuned by these materials. Here we describe the ability of free-standing CNT films to influence neuronal activity. We demonstrate that the degree of cross-linking between the CNTs has a strong impact on the electrical conductivity of the substrate, which, in turn, regulates neural circuit outputs.

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acsnano.9b02429.

    • Figures of UV–vis plots of the cross-linked materials in comparison with p-SWCNTs; Raman plots of the cross-linked materials in comparison with p-SWCNTs; TGA plots of the cross-linked materials in comparison with p-SWCNTs; TEM images of p-SWCNTs, ph-SWCNTs, and phSO3H-SWCNTs; SEM images of p-SWCNTs, ph-SWCNTs, and phSO3H-SWCNTs (PDF)

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