Abstract
In the type 2 diabetes, it has become clear that reactive oxygen species (ROS) cause reduction of glucose uptake by inhibiting the insulin-signaling pathway in muscle cells and adipocytes. We demonstrated that electrolyzed-reduced water (ERW) scavenges ROS and protects DNA from oxidative damage1). Here we found that ERW scavenges ROS in insulin-responsive L6 myotubes and mouse3T3/L1 adipocytes. Uptake of 1-deoxy-D- glucose (2-DOG) into both L6 cells and 3T3/L1 cells was stimulated by ERW in the presence or absence of insulin. This insulin-like activity of ERW was mediated by the activation of PI-3 kinase, resulting in stimulation of translocation of glucose transporter GLUT4 from microsome to plasma membrane. These results suggest that ERW may be useful to improve insulin-independent type 2 diabetes.
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References
Shirahata, S. et al. Biochem. Biophys. Res. Commun. 234, 269–274(1997)
Bashan N. et al. Am J Physiol, 262, 0682–90(1992)
Antonio Ceriello el al. Diabetes, 45, 471–477(19%)
Muller H et al. Diabetes, 40, 1440–1448(1991)
Shirahata, S. el al. Animal Cell Technology, 11, in press (1999).
D. Elizabeth Estrada et al. Diabetes, 45, 1798–1804(1996)
Student AK et al. J. Biol. Chem.. 255, 4745–50(1980)
Sargeant R el al. Am. J. Physiol, 269(Cell Physiol 38), C217–C225(1995)
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© 1999 Kluwer Academic Publishers
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Oda, M. et al. (1999). Electrolyzed and Natural Reduced Water Exhibit Insulin-Like Activity on Glucose Uptake into Muscle Cells and Adipocytes. In: Bernard, A., Griffiths, B., Noé, W., Wurm, F. (eds) Animal Cell Technology: Products from Cells, Cells as Products. Springer, Dordrecht. https://doi.org/10.1007/0-306-46875-1_90
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DOI: https://doi.org/10.1007/0-306-46875-1_90
Publisher Name: Springer, Dordrecht
Print ISBN: 978-0-7923-6075-9
Online ISBN: 978-0-306-46875-9
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