Abstract
Interactions between doxorubicin (DOX) and iron generate reactive oxygen species and contribute to DOX-induced heart failure. Hydrogen, as a selective antioxidant, is a promising potential therapeutic option for the treatment of a variety of diseases. Therefore, we investigated the preventive effects of hydrogen treatment on DOX-induced heart failure in rats. We found that cardiac function was significantly improved and that the plasma levels of oxidative-stress markers and myocardial autophagic activity were decreased in animals treated with hydrogen-containing saline. Therefore, we conclude that hydrogen-containing saline may have beneficial effects for doxorubicin-induced heart failure.
MeSH terms
- Animals
- Antibiotics, Antineoplastic / antagonists & inhibitors*
- Antibiotics, Antineoplastic / toxicity*
- Autophagy / drug effects
- Blotting, Western
- Cardiotonic Agents*
- Doxorubicin / antagonists & inhibitors*
- Doxorubicin / toxicity*
- Echocardiography
- Heart Failure / chemically induced*
- Heart Failure / diagnostic imaging
- Heart Failure / prevention & control*
- Hydrogen / chemistry
- Hydrogen / pharmacology*
- Male
- Microscopy, Electron, Transmission
- Myocardium / pathology
- Oxidative Stress / drug effects
- Pharmaceutical Solutions
- Rats
- Rats, Wistar
- Sodium Chloride / chemistry*
- Survival
- Ventricular Function, Left / drug effects
Substances
- Antibiotics, Antineoplastic
- Cardiotonic Agents
- Pharmaceutical Solutions
- Sodium Chloride
- Hydrogen
- Doxorubicin