Selected Publications
Lim, C. J., Barbour, A. T., Zaug, A. J., Goodrich, K. J., McKay, A. E., Wuttke, D. S., & Cech, T. R. The structure of human CST reveals a decameric assembly bound to telomeric DNA. Science, 368, 1081-1085 (2020).
Youmans, D.T., Gooding, A.R., Dowell, R.D., Cech, T.R. Competition between PRC2.1 and 2.2 subcomplexes regulates PRC2 chromatin occupancy in human stem cells. Mol Cell, 81, 488-501 (2021).
Zaug, A. J., Lim, C.J., Olson, C.L., Carilli, M.T., Goodrich, K.J., Wuttke, D.S., Cech, T.R., CST does not evict elongating telomerase but prevents initiation by ssDNA binding. Nucleic Acids Res, 49, 11653-11665 (2021).
Jansson-Fritzberg, L. I., Sousa, C. I., Smallegan, M. J., Song, J. J., Gooding, A. R., Kasinath, V., Rinn, J. L., & Cech, T. R. DNMT1 inhibition by pUG-fold quadruplex RNA. RNA, 29, 346–360 (2023).
Zaug, A. J., Goodrich, K. J., Song, J. J., Sullivan, A. E. & Cech, T. R. Reconstitution of a telomeric replicon organized by CST. Nature, 608, 819-825 (2022).
Hemphill, W. O., Voong, C. K., Fenske, R., Goodrich, J. A., & Cech, T. R. Multiple RNA- and DNA-binding proteins exhibit direct transfer of polynucleotides with implications for target-site search. Proc Natl Acad Sci U S A, 120, e2220537120 (2023).