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A Simple Glycol Nucleic Acid

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Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104
Cite this: J. Am. Chem. Soc. 2005, 127, 12, 4174–4175
Publication Date (Web):March 4, 2005
https://doi.org/10.1021/ja042564z
Copyright © 2005 American Chemical Society
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    Abstract

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    A glycol nucleic acid (GNA) with an acyclic propylene glycol phosphodiester backbone forms stable antiparallel duplexes following the Watson−Crick base pairing rules.

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    Experimental procedures for the synthesis of (S)-4, (R)-4, (S)-5, (R)-5, and their incorporation into oligonucleotides, UV melting curves and CD spectra. This material is available free of charge via the Internet at http://pubs.acs.org.

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