OVERVIEW: The importance of promoting physical activity in adults with chronic illness cannot be overstated. Although numerous studies have evaluated interventions developed to increase physical activity in this population, it can be difficult to interpret the results without the benefit of a statistical analysis across studies. A 2008 meta-analysis synthesized the findings of 163 reports on such studies. This article discusses the implications of those findings, describing the strategies and practices commonly used to promote physical activity in chronic illness and identifying those that are most effective.