Clinical Research
Platelet and Endothelial Activation as Potential Mechanisms Behind the Thrombotic Complications of COVID-19 Patients
Under a Creative Commons license
open access
Visual Abstract
Key Words
antiplatelet drugs
circulating microvesicles
COVID-19
IL-6
platelet activation
tissue factor
Abbreviations and Acronyms
ADP
adenosine diphosphate
CAD
coronary artery disease
COVID-19
coronavirus disease-2019
CRP
C-reactive protein
GPA
granulocyte–platelet aggregates
HS
healthy subject
IL
interleukin
IL-6R
interleukin-6 receptor
LMWH
low-molecular-weight heparin
MPA
monocyte–platelet aggregates
MV
microvesicle
NO
nitric oxide
NOS
nitric oxide synthase
PGI2
prostacyclin
PLA
platelet–leukocyte aggregates
PS
phosphatidylserine
SARS-CoV-2
severe acute respiratory syndrome-coronavirus-2
TF
tissue factor
Cited by (0)
-
The authors attest they are in compliance with human studies committees and animal welfare regulations of the authors’ institutions and Food and Drug Administration guidelines, including patient consent where appropriate. For more information, visit the Author Center .
- ∗
-
Drs. Canzano and Brambilia contributed equally to this work and are joint first authors.
- †
-
Drs. Tremoli and Camera contributed equally to this work, and are joint senior authors.
© 2021 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.