- Mexico City, Mexico City, Mexico
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Ph.D. in Pharmaceutical Sciences from Universidad Complutense of Madrid, Spain. Pharmaceutical Chemist Biologist Bach... morePh.D. in Pharmaceutical Sciences from Universidad Complutense of Madrid, Spain. Pharmaceutical Chemist Biologist Bachelor’s degree from Universidad Autónoma Metropolitana at Mexico. Professor and researcher on development and evaluation of medicines and pharmaceutical physical-chemistry and nanotechnology. He has directed theses of Bachelor's, Master's sciences, and Doctorate students. edit
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Self-microemulsifying or self-nanoemulsifying drug delivery systems (SMEDDS/SNEDDS) are well known to improve the dissolution and increase the oral bioavailability of hydrophobic drugs, including herbal extracts. Organic extracts of... more
Self-microemulsifying or self-nanoemulsifying drug delivery systems (SMEDDS/SNEDDS) are well known to improve the dissolution and increase the oral bioavailability of hydrophobic drugs, including herbal extracts. Organic extracts of Heliopsis longipes root and affinin, its main component, induce a vasodilator effect; however, they are poorly water soluble and therefore are difficult to administer and dose by the oral route. This research aimed to develop, through pseudo-ternary phase diagrams, a self-microemulsifying system prepared from an ethanolic extract of H. longipes root (HL-SMDS). In addition, the optimized lipid-based formulation was characterized and its in vitro gastrointestinal simulated dissolution was determined. The formulation composed of Transcutol, 55% (solubilizer); Tween80/PG, 10% (surfactant/co-solvent); Labrasol, 35% (surfactant); and the herbal extract was selected as optimal and identified as a SMEDDS, since when coming into contact with water, it forms a mic...
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Copper deficiency can trigger various diseases such as Amyotrophic Lateral Sclerosis (ALS), Parkinson's disease (PD) and even compromise the development of living beings, as manifested in Menkes disease (MS). Thus, the regulated... more
Copper deficiency can trigger various diseases such as Amyotrophic Lateral Sclerosis (ALS), Parkinson's disease (PD) and even compromise the development of living beings, as manifested in Menkes disease (MS). Thus, the regulated administration (controlled release) of copper represents an alternative to reduce neuronal deterioration and prevent disease progression. Therefore, we present, to the best of our knowledge, the first experimental in vitro investigation for the kinetics of copper release from MOF-74(Cu) and its distribution in vivo after oral administration in male Wistar rats. Taking advantage of the abundance and high periodicity of copper within the crystalline-nanostructured metal-organic framework material (MOF-74(Cu)), it was possible to control the release of copper due to the partial degradation of the material. Thus, we simultaneously corroborated a low accumulation of copper in the liver (the main detoxification organ) and a slight increase of copper in the brain (striatum and midbrain), demonstrating that MOF-74(Cu) is a promising pharmacological alternative (controlled copper source) to these diseases.
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The LNZ@MOF-74(Cu) sample exhibited a higher antimicrobial activity than the LNZ@MOF-74(Zn) sample due to the synergistic effect of release of linezolid and Cu(ii) ions as a consequence of the degradation of MOF-74(Cu).
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Escamoles, ant eggs (Liometopum apiculatum M), are edible insects consumed in great numbers and appreciated for their sensory characteristics, but not for their nutritional value. In Mexico, they reproduce in arid and semi-arid zones of... more
Escamoles, ant eggs (Liometopum apiculatum M), are edible insects consumed in great numbers and appreciated for their sensory characteristics, but not for their nutritional value. In Mexico, they reproduce in arid and semi-arid zones of Mexico and several states (Puebla, Tlaxcala, Hidalgo). Samples were gathered to determine reproduction conditions and perform an insect analysis to generate data composition in macronutrients, on dry basis, according to AOAC methods. The obtained data were: proteins: 42.12-50.63%; lipids: 30.27-34.96%; minerals: 6.53-7.85%; fibres: 1.91-2.56%; and soluble carbohydrates: 6.80-18.27%. Entomological material was collected in spring 2014, 3 nests for each zone, all from different altitudes and agroclimatic regions. Samples were representative for the insect supply in the areas studied. Insects are high in proteins and lipids, compared with most of the commonly consumed food, due to their high content of fatty acids; they must be refrigerated for later consumption. Minerals are moderated. Fibre and soluble carbohydrate levels are low, but an excess of proteins can be converted into carbohydrates via gluconeogenesis. Escamoles reproduce once a year in the spring, but sometimes one nest can provide escamoles eggs twice in the same season, once at the beginning and again at the end, depending on the biotic and abiotic conditions of their environment. Escamoles are a good source of nutrients; however, some rural people sell them to obtain extra income rather than consume them to improve their nutritional condition and welfare.
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Chemistry, Electron Microscopy, Pharmaceutical Technology, Powder Diffraction, Nanoparticles, and 15 morePharmaceutical Chemistry, Medicine, Controlled release, Calcium Phosphates, European, Calcium Phosphate, Particle Size, Scanning Electron Microscope, Particle Size Analysis, Reproducibility of Results, Lactose, Drug Carriers, Drug Compounding, Indomethacin, and Pharmacology and pharmaceutical sciences
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The main purpose of this article is to show the valuable characteristics that liotropic liquid crystal systems possess to be employed as new drug delivery systems. Colloidal aqueous dispersions of lyotropic liquid crystal mesophases such... more
The main purpose of this article is to show the valuable characteristics that liotropic liquid crystal systems possess to be employed as new drug delivery systems. Colloidal aqueous dispersions of lyotropic liquid crystal mesophases such as the identified as cubosomes and hexosomes, and so on, have received considerable attention due to their unique nanostructures and their thermodynamic properties, which provide the potential as a sustained drug release matrix. Additionally, their large surface area and similarity with the liquid crystal structures of intercellular lipids of stratum corneum enhances the interaction with the skin and mucous, increasing the potential for topical drug delivery efficiency of biopharmaceutical class II drugs as the antifungal ketoconazole. This article presents the results in morphological characteristics, particle size, ζ potential, flow, thermal behavior and drug release studies of hexosomes containing ketoconazole (LHLC-K) obtained with glycerol monooleate, propylene glycol monolaurate, poloxamer, and water mixtures. This colloidal system exhibits a Newtonian-type flow and a hexagonal nanostructure with a median particle size of 107 ± 20 nm and ζ potential of +4.45 ± 0.50 mV. Through differential scanning calorimetry studies, the LHLC-K demonstrated physical and chemical stability for more than six months and mesophasic thermal reversibility between 10 and 50 °C. Finally, LHLC-K releases ketoconazole following a kinetics described by the first order model. Physicochemical properties of the hexosomes containing ketoconazole are important for topical mycosis treatment administration, conditions of storage, and for its incorporation into the formulation of semi-solid dosage forms.
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Self-microemulsifying or self-nanoemulsifying drug delivery systems (SMEDDS/SNEDDS) are well known to improve the dissolution and increase the oral bioavailability of hydrophobic drugs, including herbal extracts. Organic extracts of... more
Self-microemulsifying or self-nanoemulsifying drug delivery systems (SMEDDS/SNEDDS) are well known to improve the dissolution and increase the oral bioavailability of hydrophobic drugs, including herbal extracts. Organic extracts of Heliopsis longipes root and affinin, its main component, induce a vasodilator effect; however, they are poorly water soluble and therefore are difficult to administer and dose by the oral route. This research aimed to develop, through pseudo-ternary phase diagrams, a self-microemulsifying system prepared from an ethanolic extract of H. longipes root (HL-SMDS). In addition, the optimized lipid-based formulation was characterized and its in vitro gastrointestinal simulated dissolution was determined. The formulation composed of Transcutol, 55% (solubilizer); Tween80/PG, 10% (surfactant/co-solvent); Labrasol, 35% (surfactant); and the herbal extract was selected as optimal and identified as a SMEDDS, since when coming into contact with water, it forms a micro-emulsion with droplet sizes less than 100 nm. The stability tests showed that HL-SMDS remained stable over time under extreme conditions. Furthermore, the amount of affinin released from HL-SMDS at pH 1 and 6.8 was higher than that of the ethanolic extract from H. longipes root. These results indicate that HL-SMDS is a novel alternative to improve the aqueous solubility and therefore the oral bioavailability of the ethanolic extract of H. longipes root.
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The diversity of existing food may decrease malnutrition through the consumption of underutilized species. In Mexico, the “charal” fish Chirostoma spp. is grouped in five species: Chirostoma grandocule, Chirostoma patzcuaro, Chirostoma... more
The diversity of existing food may decrease malnutrition through the consumption of underutilized species. In Mexico, the “charal” fish Chirostoma spp. is grouped in five species: Chirostoma grandocule, Chirostoma patzcuaro, Chirostoma humboltianum, Chirostoma attenuatum and Chirostoma jordani which live in lakes in the country, and they are not consumed or their demand is low. The objective of this research was to analyze the macronutrients of Chirostoma jordani charal and inform population their nutritional value to increase human nutrition. Sampling was provided at Xochimilco channels in Xochimilco, D.F., summer and winter seasons at 2009. Fish (200 g) were maintained in channels water for proximal analysis according AOAC methods (1995). The results in dry bases were: protein 74.36%, lipids 1.24%, fiber 0.27%, minerals 4.9%, and soluble carbohydrates 19.23%. This fish grants protein, plastic material essential for human development: its lipid and carbohydrate contents, sources of...
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Sulfadiazine (SDZ), a bacteriostatic agent, was hosted in MIL-53(Al) and modified-zinc MIL-53(Al,Zn).
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La Conferencia Iberoamericana de Facultades de Farmacia (COIFFA) viene desarrollando desde su fundación como Conferencia Hispanoamericana (COHIFFA) en 1992, en la Universidad de los Andes (Mérida, Venezuela) una amplia labor en el ámbito... more
La Conferencia Iberoamericana de Facultades de Farmacia (COIFFA) viene desarrollando desde su fundación como Conferencia Hispanoamericana (COHIFFA) en 1992, en la Universidad de los Andes (Mérida, Venezuela) una amplia labor en el ámbito de la formación y educación farmacéutica. Esta labor se ha traducido en declaraciones sucesivas desde la efectuada en Santiago (Chile) hasta la más reciente de Xochimilco (México). El grado de avance que han experimentado las ciencias y la práctica farmacéutica en las últimas décadas ha sido espectacular. Así se refleja en documentos de organismos y foros nacionales e internacionales. A esto se une las facilidades que en el ámbito de la movilidad internacional procuran tanto las Universidades a través de sus convenios bilaterales, como los organismos nacionales e internacionales de América Latina y de la Unión Europea, a través de los proyectos y convocatorias pertinentes. Todo ello hace aconsejable la elaboración por parte de COIFFA de un documento...
El objeto del trabajo fue cuanticar la liberacion de Indometacina (I), farmaco modelo de baja solubilidad, contenido en Acuosomas (A), mediante un metodo de dialisis y espectroscopia UV. La caracterizacion estructural se efectuo mediante... more
El objeto del trabajo fue cuanticar la liberacion de Indometacina (I), farmaco modelo de baja solubilidad, contenido en Acuosomas (A), mediante un metodo de dialisis y espectroscopia UV. La caracterizacion estructural se efectuo mediante microscopia electronica de transmision y de barrido, asi como por calorimetria diferencial de barrido y espectroscopia de infrarrojo. El tamano de particula de los aglomerados de acuosomas estan en el intervalo de 3 a 4 μm con un promedio de 3.68 μm y un error estandar de la media de 0.0082. En comparacion con la mezcla fisica (PM) los acuosomas liberaron en los primeros veinte minutos, doce veces mas indometacina y durante 24 h, se mantuvo esta liberacion en una relacion 1.6 a uno. El infrarrojo y la calorimetria indican la formacion de interacciones entre las moleculas dentro de los acuosomas
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The Ibero-American Conference of Faculties of Pharmacy (COIFFA) has been developing a wide-ranging task in the field of pharmaceutical training and education since its foundation as Hispanic-American Conference (COHIFFA) in 1992, at the... more
The Ibero-American Conference of Faculties of Pharmacy (COIFFA) has been developing a wide-ranging task in the field of pharmaceutical training and education since its foundation as Hispanic-American Conference (COHIFFA) in 1992, at the Universidad de los Andes (Merida, Venezuela). This work has been materialized into successive statements from the one made in Santiago (Chile) to the most recent one in Xochimilco (Mexico). The degree of progress that the sciences and pharmaceutical practice have experienced in recent decades has been spectacular. This is reflected in documents from national and international organizations and forums. To this is added the facilities that, in the field of international mobility, universities get through their bilateral agreements, as well as with national and international organizations in Latin America and the European Union, through the relevant projects and calls. All this makes advisable the elaboration on the part of COIFFA of a framework documen...
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El ketoconazol es un farmaco antimicotico muy utilizado. A pesar de su amplio espectro como agente antifungico, adolece de dos caracteristicas que hacen dificil su utilizacion, es poco soluble en agua y ademas se degrada facilmente. En... more
El ketoconazol es un farmaco antimicotico muy utilizado. A pesar de su amplio espectro como agente antifungico, adolece de dos caracteristicas que hacen dificil su utilizacion, es poco soluble en agua y ademas se degrada facilmente. En este trabajo se informa de un sistema basado en nanoparticulas lipidicas solidas (SLN) para ser empleado como sistema de liberacion modificada de ketoconazol y asi mejorar su actividad terapeutica. Las nanoparticulas lipidicas fueron preparadas por el metodo de fusion-homogeneizacion y caracterizadas en tamano, potencial Z, forma y actividad antifungica. La formulacion optimizada genero nanoparticulas esfericas con un tamano promedio de 82 ± 0.75 nm y un potencial Z de -14 ± 0.05 mV. El tamano de particula en suspension incremento ligeramente en el transcurso de un mes. Para garantizar la estabilidad del sistema, estas fueron liofilizadas. Tambien se ensayo la eficacia de la actividad antifungica del sistema contra Candida albicans, los resultados sug...
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... La prescripción de antibióticos y quimioterápicos para el tratamiento de infeccionesodontogénicas y como ... Tabla 1. Bacterias de la flora presentes en las infecciones de caries y ... Tabla 3. Clasificación de los procedimientos... more
... La prescripción de antibióticos y quimioterápicos para el tratamiento de infeccionesodontogénicas y como ... Tabla 1. Bacterias de la flora presentes en las infecciones de caries y ... Tabla 3. Clasificación de los procedimientos estomatológicos por especialidad, en función de los ...
Abstract Today it is important to define the difference between nanotechnology and nanoscience. On one hand, we are looking for new strategies in technology to enclose drugs, biological substances of plants or insects that have shown... more
Abstract Today it is important to define the difference between nanotechnology and nanoscience. On one hand, we are looking for new strategies in technology to enclose drugs, biological substances of plants or insects that have shown pharmacological activity and other type of substances, on the other hand, we seek to improve drug direction and reduce adverse effects for patients. Based on this, we have to know physicochemical characteristics of drugs and physical characteristics of devices used in pharmaceutical microprocesses. These devices are characterized by small internal flux areas that allow laminar flux (microfluidic systems). Examples of nanoparticles and microparticles that will involve pharmaceutical microprocesses in this chapter are: liquid crystals (LC), systems based on solid lipid nanoparticles (SLN) with a drug that belongs to biopharmaceutical classification system (II). Finally, we talk about synthetic polymersomes that imitate biological membrane functions.
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The information published in the last years in relation to the appropriate use of antimicrobial prophylaxis (AP) in dental practice, in general, and in periodontal procedures, in particular, is analyzed. The data presented show the... more
The information published in the last years in relation to the appropriate use of antimicrobial prophylaxis (AP) in dental practice, in general, and in periodontal procedures, in particular, is analyzed. The data presented show the current use of AP that is subject to a series of criteria, such as the type of operation or odontological procedure, the level of infection risk per individual according to pathology, age, physiological condition, the site of the wound or of the surgical excision and if it is in a clean or contaminated zone, as well as the habitual microbial flora and the susceptibility of the microorganisms to the antimicrobial agents. All this will determine the adequate posology not to generate bacterial resistance.
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RESUMEN: Los sistemas materiales bioinspirados surgen a partir del mayor conocimiento de diferentes organismos vivos tales como: plantas, insectos, mamíferos y organismos marinos, por mencionar algunos. Estas formas de diseñar, procesar y... more
RESUMEN: Los sistemas materiales bioinspirados surgen a partir del mayor conocimiento de diferentes organismos vivos tales como: plantas, insectos, mamíferos y organismos marinos, por mencionar algunos. Estas formas de diseñar, procesar y ensamblar estructuras complejas para generar materiales altamente desarrollados con recursos mínimos pueden servir como modelo para diseñar sistemas de liberación de agentes terapéuticos (SLAT) con funciones óptimas. Los materiales bioinspirados que involucran el uso de superficies superhidrofóbicas y el ensamblado capa por capa están siendo implementados exitosamente para crear estructuras poliméricas o híbridas. Mimetizando la superficie, la forma, textura y movimientos de las células, dichos materiales pueden ayudar a superar el fenómeno de la fagocitosis y de esta forma hacer que los nanoacarreadores (vectores) permanezcan mayor tiempo dentro de la circulación sistémica para incrementar el control espaciotemporal de la liberación de agentes ter...
RESUMEN: Los sustitutos de sangre artificial poseen varias ventajas sobre las transfusiones donde participan donadores, por lo que se ha desarrollado sangre artificial tomando en consideración la función principal de la sangre, que es el... more
RESUMEN: Los sustitutos de sangre artificial poseen varias ventajas sobre las transfusiones donde participan donadores, por lo que se ha desarrollado sangre artificial tomando en consideración la función principal de la sangre, que es el transporte de oxígeno a los tejidos por medio de los eritrocitos. Se han sugerido dos estrategias para el desarrollo de acarreadores de oxígeno: el enfoque biomimético con Hemoglobin-based oxygen carriers (HBOC por sus siglas en inglés) y el enfoque abiótico. El primer enfoque imita la naturaleza en la forma de transportar el oxígeno a los tejidos, mientras que el segundo utiliza productos químicos sintéticos para lograr el mismo resultado. Así, el origen de las células artificiales está relacionado con los acarreadores de oxígeno en la forma de polihemoglobinas y hemoglobinas conjugadas y aunque una célula completamente artificial equiparable al glóbulo rojo es todavía un sueño, el desarrollo de membranas lipídicas, poliméricas biodegradables y nan...
La piel es el órgano humano más grande, destacando su actividad de barrera, que abarca la protección a variaciones de temperatura y radiaciones, así como a la penetración de microrganismos patógenos y de sustancias orgánicas e inorgánicas... more
La piel es el órgano humano más grande, destacando su actividad de barrera, que abarca la protección a variaciones de temperatura y radiaciones, así como a la penetración de microrganismos patógenos y de sustancias orgánicas e inorgánicas capaces de producir enfermedad cutánea o sistémica. Su amplia superficie representa también un enorme potencial para la administración de diversas sustancias con fines locales y sistémicos; de ahí la tendencia actual en tecnología y nanotecnología farmacéutica por diseñar sistemas innovadores de uso tópico y transdérmico que mimetizando componentes de la piel persiguen incrementar la capacidad para entregar fármacos y biomoléculas con mayor eficacia y seguridad que la representada por otras vías y formas de dosificación. Este artículo hace una somera exposición de los avances en el conocimiento de la estructura y función de barrera de la piel, subrayando la composición y propiedades mesofásicas de los lípidos intercelulares que controlan la difusió...
The main purpose of this article is to show the valuable characteristics that liotropic liquid crystal systems possess to be employed as new drug delivery systems. Colloidal aqueous dispersions of lyotropic liquid crystal mesophases such... more
The main purpose of this article is to show the valuable characteristics that liotropic liquid crystal systems possess to be employed as new drug delivery systems. Colloidal aqueous dispersions of lyotropic liquid crystal mesophases such as the identified as cubosomes and hexosomes, and so on, have received considerable attention due to their unique nanostructures and their thermodynamic properties, which provide the potential as a sustained drug release matrix. Additionally, their large surface area and similarity with the liquid crystal structures of intercellular lipids of stratum corneum enhances the interaction with the skin and mucous, increasing the potential for topical drug delivery efficiency of biopharmaceutical class II drugs as the antifungal ketoconazole. This article presents the results in morphological characteristics, particle size, ζ potential, flow, thermal behavior and drug release studies of hexosomes containing ketoconazole (LHLC-K) obtained with glycerol mono...
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COPHELA (Cooperation in Quality Assurance for Pharmacy Education and Training between Europe and Latin America), a collaborative project between the European Union (EU) and Latin America, will produce on-line courses for the master degree... more
COPHELA (Cooperation in Quality Assurance for Pharmacy Education and Training between Europe and Latin America), a collaborative project between the European Union (EU) and Latin America, will produce on-line courses for the master degree in pharmacy. The program runs from 2019 through 2021. It is funded by the Erasmus+ program of the Education, Audio-visual and Culture Executive Agency (EACEA) of the European Commission. The partners are EU and Latin American universities. These are accompanied by associated partners from EU and Latin American universities, as well as from governmental and non-governmental organizations, such as pharmacy chambers and educational associations. The project is coordinated by the University of Granada, Spain (first author of this paper). It will produce distance learning master degree courses in a dozen fields of specialized pharmaceutical science education and practice, ranging from patient care to industrial pharmacy. This paper describes the design ...
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The present invention regards to a pharmaceutical nanoparticulate system based in aqueous dispersions of hexosomal lyotropic liquid crystals and one or more active principles ingredients and / or biomolecules. This in illustrative but not... more
The present invention regards to a pharmaceutical nanoparticulate system based in aqueous dispersions of hexosomal lyotropic liquid crystals and one or more active principles ingredients and / or biomolecules. This in illustrative but not limiting terms, including antimicrobials and / or antifungals and / or antiparasitics, analgesics and / or keratolytics and its method of preparation and their pharmaceutical compositions in liquid, semisolid, colloidal dispersion and / or mixture of these, for human and animal use, being with topical application on the skin, their layers and annexes including mucous membranes, scalp and nails. The system functions as a vehicle for liberation topical or dermal for the active ingredient (s), protecting, taking care and / or vectoring the molecules in the skin, its layers and annexes including mucous membranes, scalp and nails. The formulated compositions favor stability and control in the release of the active principles and / or biomolecules in a quantitative way and thus facilitating their availability and penetrability, which provides greater efficacy, efficiency and safety to the compositions, since that its permanence in the treated area allows the diffusion, penetration and retention of the active principle ingredient.
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The present invention regards to a composition for ophthalmic application which contains, among other things, a controlled release nanoparticulate pharmaceutical system. In turn, the nanoparticulate pharmaceutical system is made up of a... more
The present invention regards to a composition for ophthalmic application which contains, among other things, a controlled release nanoparticulate pharmaceutical system.
In turn, the nanoparticulate pharmaceutical system is made up of a inorganic nano-crystalline nucleus and one or more layers of a polyhydroxy compound and coating particles of one or more drugs. This system increases bioavailability by enhancing the effect of the drug
on intraocular pressure due to the nanometric and / or micrometric size of the aqueous solutions, favoring the penetration in therapeutic doses through the ocular membrane, so consequently, the dose to be applied to the eye is considerably reduced, reducing the effects side effects of the drug in question that may occur during treatment. The pharmaceutical nanoparticulate system works as a drugs delivery vehicle, protecting, conserving and vectoring the biological molecules to the ocular system.
In turn, the nanoparticulate pharmaceutical system is made up of a inorganic nano-crystalline nucleus and one or more layers of a polyhydroxy compound and coating particles of one or more drugs. This system increases bioavailability by enhancing the effect of the drug
on intraocular pressure due to the nanometric and / or micrometric size of the aqueous solutions, favoring the penetration in therapeutic doses through the ocular membrane, so consequently, the dose to be applied to the eye is considerably reduced, reducing the effects side effects of the drug in question that may occur during treatment. The pharmaceutical nanoparticulate system works as a drugs delivery vehicle, protecting, conserving and vectoring the biological molecules to the ocular system.