Current Issue
- April 30, 2024
- vol. 121
- no. 18
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Persistent viral reservoirs in memory T cells harbor latent replication-competent proviruses that can rebound after interruption of antiretroviral therapy. Although HIV proviruses integrate into transcriptionally active genes distributed ...Using an immunofluorescence assay based on CRISPR-dCas9-gRNA complexes that selectively bind to the HIV LTR (HIV Cas-FISH), we traced changes in HIV DNA localization in primary effector T cells from early infection until the cells become quiescent as they ...
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Models for informing sustainability interventions in complex adaptive systems involving nature-society interactions are challenging to construct due to lack of detailed, quantitative data on the changing structure of system interactions. Here, ...Sustainability challenges related to food production arise from multiple nature-society interactions occurring over long time periods. Traditional methods of quantitative analysis do not represent long-term changes in the networks of system components, ...
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Respiratory virus infections in humans are a significant global health concern, causing a wide range of diseases with substantial morbidity and mortality worldwide. This underscores the urgent need for effective interventions to reduce the ...Respiratory virus infections in humans cause a broad-spectrum of diseases that result in substantial morbidity and mortality annually worldwide. To reduce the global burden of respiratory viral diseases, preventative and therapeutic interventions that are ...
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Emotions coordinate our behavior and physiological states during survival-salient events and pleasurable interactions. Even though we are often consciously aware of our current emotional state, such as anger or happiness, the mechanisms giving ...Emotions are often felt in the body, and somatosensory feedback has been proposed to trigger conscious emotional experiences. Here we reveal maps of bodily sensations associated with different emotions using a unique topographical self-report method. In ...
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Understanding how humans represent concepts and their relations is a crucial question in cognitive (neuro)science. By analyzing eye movements during verbal fluency tasks, we observed that people directed their gaze to the left or right before ...Functional neuroimaging studies indicate that the human brain can represent concepts and their relational structure in memory using coding schemes typical of spatial navigation. However, whether we can read out the internal representational geometries of ...
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