PIP: A brief review of the literature concerning the effects of oral contraceptives on liver function is presented. Evidence generally suggests that although oral contraceptives do effect the excretory function of liver cells, it is of little clinical importance. It is believed that estrogens and progesterones in a much greater dosage than is currently (1966) present in oral contraceptives would have to be given to do any damage. Treatment with oral contraceptives is nonetheless inadvisable if previous cholestasis of pregnancy, primary biliary cirrhosis, or a hereditary disorder of hepatic excretory function is present. If bilirubinuria or jaundice occur during treatment, the pill should be withdrawn.