The Colorado program to treat hemophiliacs using hypnosis has been described. Those using hypnosis have realized a reduction in the need for transfusions, which results in a decrease in the development of inhibitors, less potential exposure to the AIDS virus and a lower incidence of liver and kidney damage. A decrease in the frequency and severity of bleeding episodes results in less morbidity and better coping in the face of HIV infection. Self-hypnosis has provided many bleeders with increased feelings of control and confidence and improved the quality of their lives. The field of psychoneuroimmunology gives a scientific rationale for what we have clinically recognized and implemented for years: self-hypnosis to alleviate stress has the potential to improve immune functioning. In bleeders and others who are HIV positive, it may augment medical attempts to impede the onset of AIDS.