Mutation frequencies at defined single codon sites in vesicular stomatitis virus and poliovirus can be increased only slightly by chemical mutagenesis

J J Holland; E Domingo; J C de la Torre; D A Steinhauer

doi:10.1128/JVI.64.8.3960-3962.1990

Mutation frequencies at defined single codon sites in vesicular stomatitis virus and poliovirus can be increased only slightly by chemical mutagenesis

J Virol. 1990 Aug;64(8):3960-2. doi: 10.1128/JVI.64.8.3960-3962.1990.

Authors

J J Holland¹, E Domingo, J C de la Torre, D A Steinhauer

Affiliation

¹ Institute of Molecular Genetics, University of California, San Diego, La Jolla 92093.

Abstract

Mutagenesis by a variety of chemical mutagens conferred only 1.1- to 2.8-fold increases in mutation frequencies at defined single base sites in vesicular stomatitis virus and poliovirus.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Animals
Azacitidine / pharmacology
Cell Line
Codon / genetics*
Ethyl Methanesulfonate / pharmacology
Fluorouracil / pharmacology
Hydrogen-Ion Concentration
Mutagens / pharmacology*
Mutation*
Nitrous Acid / pharmacology
Poliovirus / drug effects
Poliovirus / genetics*
RNA, Messenger / genetics*
Vesicular stomatitis Indiana virus / drug effects
Vesicular stomatitis Indiana virus / genetics*

Substances

Codon
Mutagens
RNA, Messenger
Ethyl Methanesulfonate
Azacitidine
Nitrous Acid
Fluorouracil

Grants and funding

AI 14627/AI/NIAID NIH HHS/United States