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Iron is maintained as Fe(II) under aerobic conditions in erythroid cells

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Abstract

It was found that in rabbit erythrocytes loaded with Fe(II) (using the ionophore, A23187) over 90% of this metal is maintained in its ferrous form. In rabbit reticulocytes more than 50% of the transferrin-donated nonheme iron proved to be divalent. These results strongly suggest that under aerobic conditions the intracellular environment of intact erythroid cells is reducing for iron.

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Authors and Affiliations

  1. National Institute of Haematology and Blood Transfusion, 1113, Budapest, Hungary

    A. Egyed’ & Paul Saltman

  2. Department of Biology, University of California, 92093, San Diego, La Jolla, California, USA

    Paul Saltman

Authors
  1. A. Egyed’
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  2. Paul Saltman
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Egyed’, A., Saltman, P. Iron is maintained as Fe(II) under aerobic conditions in erythroid cells. Biol Trace Elem Res 6, 357–364 (1984). https://doi.org/10.1007/BF02989243

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  • DOI: https://doi.org/10.1007/BF02989243

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