A comparative study of the floral ontogeny and anatomy of Francoa, with one species, and Greyia, with three species, is made. Flowers arise nearly synchronously on terminal raceme‐like inflorescences with abortive growing tip. In Greyia, development of flowers shows a tendency toward monosymmetry, expressed in the initiation sequence of floral organs. Both genera are weakly obdiplostemonous by a later displacement of antepetalous stamens (“secondary obdiplostemony”), and they develop a comparable semi‐inferior, strongly grooved ovary with axile placentation. The staminodial nature of nectaries is rejected for both genera. The floral ontogenetic, anatomical, and morphological similarities of the two genera are obvious and are consistent with the proposal for a close relationship between Greyia and Francoa supported by molecular data.