Animal Models for Periodontal Tissue Engineering: A Knowledge-Generating Process
Publication: Tissue Engineering Part C: Methods
Volume 23, Issue Number 12
Abstract
The human periodontium is a uniquely complex vital structure, supporting and anchoring the teeth in their alveolar sockets, thereby playing a decisive role in tooth homeostasis and function. Chronic periodontitis is a highly prevalent immune-inflammatory disease of the periodontium, affecting 15% of adult individuals, and is characterized by progressive destruction of the periodontal tooth-investing tissues, culminating in their irreversible damage. Current periodontal evidence-based treatment strategies achieve periodontal healing via repair processes, mostly combating the inflammatory component of the disease, to halt or reduce prospective periodontal tissue loss. However, complete periodontal tissue regeneration remains a hard fought-for goal in the field of periodontology and multiple in vitro and in vivo studies have been conducted, in the conquest to achieve a functional periodontal tissue regeneration in humans. The present review evaluates the current status of periodontal regeneration attempted through tissue-engineering concepts, ideal requirements for experimental animal models under investigation, the methods of induction and classification of the experimentally created periodontal defects, types of experimental defects employed in the diverse animal studies, as well as the current state of knowledge obtained from in vivo animal experiments, with special emphasis on large animal models.
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Published In
Tissue Engineering Part C: Methods
Volume 23 • Issue Number 12 • December 2017
Pages: 900 - 925
PubMed: 28795622
Copyright
Copyright 2017, Mary Ann Liebert, Inc.
History
Published in print: December 2017
Published online: 1 December 2017
Published ahead of print: 25 October 2017
Published ahead of production: 10 August 2017
Accepted: 28 July 2017
Received: 16 March 2017
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