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Hybrid Cell Line from a Cloned Immunoglobulin-Producing Mouse Myeloma and a Nonproducing Mouse Lymphoma

Behzad Mohit and Kang FanAuthors Info & Affiliations
Science
8 Jan 1971
Vol 171, Issue 3966
pp. 75-77
DOI: 10.1126/science.171.3966.75
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Abstract

A hybrid cell line was established by cell fusion between a cloned Balb/c myeloma that is resistant to 8-azaguanine and produces immunoglobulin (γG and free kappa chain) and C57BL/6N lymphoma that is resistant to bromodeoxyuridine and does not produce immunoglobulins. The hybrid cells contained the membrane antigens of both parents; they synthesized free kappa chain; no synthesis of γG (γ2a) heavy chain was detected.

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Science
Volume 171 | Issue 3966
8 January 1971

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© 1971.

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Published in print: 8 January 1971

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Behzad Mohit
Cell Chemistry Laboratory, Clinical Pathology Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20014
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Kang Fan
Cell Chemistry Laboratory, Clinical Pathology Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20014
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  • Behzad Mohit,
  • Kang Fan
,
Hybrid Cell Line from a Cloned Immunoglobulin-Producing Mouse Myeloma and a Nonproducing Mouse Lymphoma.Science171,75-77(1971).DOI:10.1126/science.171.3966.75

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