A Rapidly Evolving Homeobox at the Site of a Hybrid Sterility Gene
Abstract
The homeodomain is a DNA binding motif that is usually conserved among diverse taxa. Rapidly evolving homeodomains are thus of interest because their divergence may be associated with speciation. The exact site of the Odysseus (Ods) locus of hybrid male sterility inDrosophila contains such a homeobox gene. In the past half million years, this homeodomain has experienced more amino acid substitutions than it did in the preceding 700 million years; during this period, it has also evolved faster than other parts of the protein or even the introns. Such rapid sequence divergence is driven by positive selection and may contribute to reproductive isolation.
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Supported by National Science Foundation and National Institutes of Health grants to C.-I.W. We are indebted to M. Itoh for collaborating with us in construction of the D. simulans and D. mauritiana genomic libraries and to T. Hazelrigg for sending us the testis cDNA library. We also thank C. H. Langley, N. Patel, M. F. Polopalli, I. Boussey, C. M. Bergman, P. Andolfatto, M. Long, and S. M. Rollmann for technical consultations and helpful discussions.
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Published In
Science
Volume 282 | Issue 5393
20 November 1998
20 November 1998
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Received: 6 July 1998
Accepted: 7 October 1998
Published in print: 20 November 1998
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