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Expert Review of Anti-infective Therapy Volume 4, 2006 - Issue 5
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Review

Resistance to anti-influenza drugs: adamantanes and neuraminidase inhibitors

Aeron C Hurt World Health Organization Collaborating Centre for Reference and Research on Influenza, Monash University, School of Applied Sciences, 45 Poplar Road, Parkville, Victoria 3052, Australia. aeron.hurt@influenzacentre.org
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Hui-Ting Ho World Health Organization Collaborating Centre for Reference and Research on Influenza; Monash University, School of Applied Sciences, 45 Poplar Road, Parkville, Victoria 3052; Churchill, Victoria 3842, Australia. Hui.Ho@sci.monash.edu.au
&
Ian Barr World Health Organization Collaborating Centre for Reference and Research on Influenza: Monash University, School of Applied Sciences, 45 Poplar Road, Parkville, Victoria 3052; Churchill, Victoria 3842, Australia. Ian.Barr@influenzacentre.org
Pages 795-805 | Published online: 10 Jan 2014
 
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Abstract

Development of effective drugs for the treatment or prevention of epidemic and pandemic influenza is important in order to reduce its impact. Adamantanes and neuraminidase inhibitors are two classes of anti-influenza drugs available for influenza therapy currently. However, emergence of resistance to these drugs has been detected, which raises concerns regarding their widespread use. In this review, resistance to the adamantanes and neuraminidase inhibitors will be discussed in relation to both epidemic and pandemic influenza viruses.

Acknowledgements

The WHO Collaborating Center for Reference and Research on Influenza is supported by the Australian Commonwealth Department of Health and Ageing.

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