Multipolar RFA of the liver: Influence of intrahepatic vessels on ablation zones and appropriateness of CECT in detecting ablation dimensions - Results of an in-vivo porcine liver model

Issue title: Selected papers from the Neubrandenburg Conference, 8-9 June, 2018

Article type: Research Article

Authors: Vahldiek, Janis L.^{a; *} | Erxleben, Christoph^a | Bressem, Keno Kyrill^a | Gemeinhardt, Ole^b | Poch, Franz^b | Hiebl, Bernhard^c | Lehmann, Kai S.^b | Hamm, B.^a | Niehues, Stefan M.^a

Affiliations: [a] Department of Radiology, Charité-University Medicine Berlin, Berlin, Germany | [b] Department of Surgery, Charité-University Medicine Berlin, Berlin, Germany | [c] Institute for Animal Hygiene, Animal Welfare and Farm Animal Behaviour, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany

Correspondence: [*] Corresponding author: Dr. med. Janis Lucas Vahldiek, Charité – Universitätsmedizin Berlin, Campus Benjamin Franklin - Klinik für Radiologie, Hindenburgdamm 30, 12203 Berlin, Germany. Tel.: +49 30 8445 3041; Fax: +49 30 450 7 527 953; E-mail: [email protected].

Abstract: BACKGROUND:Radiofrequency ablation (RFA) is an important treatment option for hepatic tumors and metastases. Post-ablation recurrence rates are reported up to 36.5 percent and seem to depend on tumor size, intrahepatic localization of tumors and adjacent hepatic vessels. Multipolar RFA has the potential to overcome/reduce these limitations. Experimental and standardized data on achievable lesion sizes, influence of hepatic vessels and non-invasive evaluation of complete ablation is still insufficient. OBJECTIVES:The aim of this study was to evaluate the influence of intrahepatic vessels on shape and size of multipolar RF-ablation zones in healthy porcine liver and to evaluate the appropriateness of immediate post-ablation contrast-enhanced computed tomography (CECT) in detecting RF-ablation dimensions. MATERIAL AND METHODS:We conducted multipolar RFAs in each of the livers of 10 healthy, narcotized and laparotomized domestic pigs by inserting three parallel probes with a constant probe distance and a constant energy supply. In 4 ablations we interrupted hepatic blood flow using Pringle’s maneuver. Immediate post-ablation CECT scans were acquired. After euthanasia the livers were sliced perpendicularly to the probes at the probes’ active centers. CECT scans were reconstructed equivalently in order to compare RF-lesion size and shape to the macroscopic sections. RESULTS:In total, 19 RF-lesions were analyzed. Every RF-lesion that was ablated during physiological liver perfusion showed an irregular and cloverleaf-like shape (n = 15). Interrupting the hepatic blood flow during RFA led to well-defined, round and homogeneous ablation zones which were 3.8 times larger compared to RF-lesions ablated during continuous hepatic perfusion (n = 4). We found an excellent correlation between immediate post-ablation CECT slices and macroscopic sections when comparing RF-lesion diameters and area, although CECT tended to overestimate ablation dimensions. CONCLUSIONS:The interruption of hepatic blood flow using Pringle’s maneuver during multipolar RFA with three applicators significantly reduces heat sink effects of hepatic vessels and generates large and coherent ablation zones. This approach should be considered in each case of ablation planning adjacent to larger hepatic vessels or when ablating larger tumor volumes. Immediate post-ablation CECT has limited value in detecting incomplete RFA periprocedurally.

Keywords: Liver perfusion, animals, catheter ablation, electrodes, imaging, three-dimensional/*methods, multidetector computed tomography, radiography, Interventional/methods, *contrast media

DOI: 10.3233/CH-189313

Journal: Clinical Hemorheology and Microcirculation, vol. 70, no. 4, pp. 467-476, 2018