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Effect of Mts1 on the Structure and Activity of Nonmuscle Myosin II†

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Department of Biochemistry and Cancer Center, University of Rochester, 601 Elmwood Avenue, Rochester, New York 14642, Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892, and Laboratory of Cellular Biology, National Institute on Deafness and Other Communication Disorders, Bethesda, Maryland 20892
Cite this: Biochemistry 1997, 36, 51, 16321–16327
Publication Date (Web):December 23, 1997
https://doi.org/10.1021/bi971182l
Copyright © 1997 American Chemical Society
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    Abstract

    The mts1 gene codes for a 9 kDa protein belonging to the S100 subfamily of Ca2+-binding proteins and is known to play a role in metastasis. Its role in metastasis may be through cellular locomotion, as transfection of mts1 into mouse mammary adenocarcinoma cells increases cellular motility in modified Boyden chemotaxis chambers. The Mts1 protein interacts with nonmuscle myosin II in the presence of Ca2+ with an affinity of approximately 7.9 × 104 M-1 and an approximate stoichiometry of 3 mol of Mts1/mol of myosin heavy chain. No interaction was found with myosin I or myosin V. The binding site of Mts1 on myosin is in the rod region, particularly to the light meromyosin portion of the rod. To understand the mechanism by which Mts1 alters cellular motility, we examined its effect on myosin structure and activity. Cosedimentation analysis and electron microscopy suggest that Mts1 destabilizes myosin filaments. In the presence of Ca2+, Mts1 inhibits the actin-activated MgATPase activity of myosin in vitro. The data demonstrate an effect of Mts1 on both myosin structure and function, and suggest a route through which Mts1 affects motility as well as metastasis.

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    †

     Research was supported by NIH Cancer Center Core Grant P30CA11198 and by NIH Grant R01CA62376 to S.B.Z. H.L.F. has been supported as a trainee on the NRSA Genetics and Regulation Training Grant and on the Elon Huntington Hooker Graduate Fellowship.

    *

     Author to whom correspondance should be addressed.

    ‡

     Department of Biochemistry, University of Rochester.

    §

     Present address:  Dana-Farber Cancer Institute, Room D810B, 44 Binney St., Boston, MA 02115. Telephone:  (617) 632-4686. Fax:  (617) 632-4680.

    ‖

     National Heart, Lung, and Blood Institute.

    ⊥

     National Institute on Deafness and Other Communication Disorders.

    #

     Cancer Center, University of Rochester.

    ✗

     Abstract published in Advance ACS Abstracts, December 1, 1997.

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    2. Vladimir N. Malashkevich, Kristen M. Varney, Sarah C. Garrett, Paul T. Wilder, David Knight, Thomas H. Charpentier, Udupi A. Ramagopal, Steven C. Almo, David J. Weber and Anne R. Bresnick . Structure of Ca2+-Bound S100A4 and Its Interaction with Peptides Derived from Nonmuscle Myosin-IIA. Biochemistry 2008, 47 (18) , 5111-5126. https://doi.org/10.1021/bi702537s
    3. Lu Zhang, Xiaolei Zhou, Bowen Liu, Xuhe Shi, Xianmeng Li, Feifei Xu, Xueli Fu, Xue Wang, Kai Ye, Tianzhi Jin, Huimin Sun, Qianqian Li, Weiying Zhang, Lihong Ye. HBXIP blocks myosin-IIA assembly by phosphorylating and interacting with NMHC-IIA in breast cancer metastasis. Acta Pharmaceutica Sinica B 2023, 13 (3) , 1053-1070. https://doi.org/10.1016/j.apsb.2022.11.025
    4. Lu Wang, Pasquale Chitano, Chun Y. Seow. Filament evanescence of myosin II and smooth muscle function. Journal of General Physiology 2021, 153 (3) https://doi.org/10.1085/jgp.202012781
    5. Cláudia Brito, Sandra Sousa. Non-Muscle Myosin 2A (NM2A): Structure, Regulation and Function. Cells 2020, 9 (7) , 1590. https://doi.org/10.3390/cells9071590
    6. Laura L. Gonzalez, Karin Garrie, Mark D. Turner. Role of S100 proteins in health and disease. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2020, 1867 (6) , 118677. https://doi.org/10.1016/j.bbamcr.2020.118677
    7. Min Du, Guozheng Wang, Igor L. Barsukov, Stephane R. Gross, Richard Smith, Philip S. Rudland. Direct interaction of metastasis-inducing S100P protein with tubulin causes enhanced cell migration without changes in cell adhesion. Biochemical Journal 2020, 477 (6) , 1159-1178. https://doi.org/10.1042/BCJ20190644
    8. Siri D. Taxerås, María Galán, Laura Campderros, Irene Piquer‐Garcia, Silvia Pellitero, Eva Martínez, Rocío Puig, Icíar Lucena, Jordi Tarascó, Pau Moreno, José Balibrea, Joan Bel, Marta Murillo, María Martínez, Marta Ramon‐Krauel, Manel Puig‐Domingo, Francesc Villarroya, Carles Lerin, David Sánchez‐Infantes. Differential association between S100A4 levels and insulin resistance in prepubertal children and adult subjects with clinically severe obesity. Obesity Science & Practice 2020, 6 (1) , 99-106. https://doi.org/10.1002/osp4.381
    9. Peter Arner, Paul Petrus, David Esteve, Anne Boulomié, Erik Näslund, Anders Thorell, Hui Gao, Ingrid Dahlman, Mikael Rydén. Screening of potential adipokines identifies S100A4 as a marker of pernicious adipose tissue and insulin resistance. International Journal of Obesity 2018, 42 (12) , 2047-2056. https://doi.org/10.1038/s41366-018-0018-0
    10. Péter Ecsédi, Neil Billington, Gyula Pálfy, Gergő Gógl, Bence Kiss, Éva Bulyáki, Andrea Bodor, James R. Sellers, László Nyitray. Multiple S100 protein isoforms and C-terminal phosphorylation contribute to the paralog-selective regulation of nonmuscle myosin 2 filaments. Journal of Biological Chemistry 2018, 293 (38) , 14850-14867. https://doi.org/10.1074/jbc.RA118.004277
    11. Ying Liu, Yue-Hang Geng, Hui Yang, Han Yang, Yan-Ting Zhou, Hong-Quan Zhang, Xin-Xia Tian, Wei-Gang Fang. Extracellular ATP drives breast cancer cell migration and metastasis via S100A4 production by cancer cells and fibroblasts. Cancer Letters 2018, 430 , 1-10. https://doi.org/10.1016/j.canlet.2018.04.043
    12. Hoku West-Foyle, Priyanka Kothari, Jonathan Osborne, Douglas N. Robinson. 14-3-3 proteins tune non-muscle myosin II assembly. Journal of Biological Chemistry 2018, 293 (18) , 6751-6761. https://doi.org/10.1074/jbc.M117.819391
    13. Fei Fei, Jie Qu, Mingqing Zhang, Yuwei Li, Shiwu Zhang. S100A4 in cancer progression and metastasis: A systematic review. Oncotarget 2017, 8 (42) , 73219-73239. https://doi.org/10.18632/oncotarget.18016
    14. Stephane R. Gross. The Actomyosin Network and Cellular Motility: A S100A4 Regulatory View into the Process. 2017https://doi.org/10.5772/66940
    15. Beáta Biri-Kovács, Bence Kiss, Henrietta Vadászi, Gergő Gógl, Gyula Pálfy, György Török, László Homolya, Andrea Bodor, László Nyitray, . Ezrin interacts with S100A4 via both its N- and C-terminal domains. PLOS ONE 2017, 12 (5) , e0177489. https://doi.org/10.1371/journal.pone.0177489
    16. Venkaiah Betapudi. Non-muscle Myosin II Motor Proteins in Human Health and Diseases. 2017, 79-107. https://doi.org/10.1007/978-981-10-4298-0_5
    17. Bence Kiss, Lajos Kalmár, László Nyitray, Gábor Pál. Structural determinants governing S100A4‐induced isoform‐selective disassembly of nonmuscle myosin II filaments. The FEBS Journal 2016, 283 (11) , 2164-2180. https://doi.org/10.1111/febs.13728
    18. Sarah M. Heissler, James R. Sellers. Various Themes of Myosin Regulation. Journal of Molecular Biology 2016, 428 (9) , 1927-1946. https://doi.org/10.1016/j.jmb.2016.01.022
    19. Bridget Hindman, Zoe Goeckeler, Kostas Sierros, Robert Wysolmerski, . Non-Muscle Myosin II Isoforms Have Different Functions in Matrix Rearrangement by MDA-MB-231 Cells. PLOS ONE 2015, 10 (7) , e0131920. https://doi.org/10.1371/journal.pone.0131920
    20. Anne R. Bresnick, David J. Weber, Danna B. Zimmer. S100 proteins in cancer. Nature Reviews Cancer 2015, 15 (2) , 96-109. https://doi.org/10.1038/nrc3893
    21. Mikael Brisslert, Li Bian, Mattias N.D. Svensson, Rita F. Santos, Ing-Marie Jonsson, Igor Barsukov, Malin Erlandsson, Karin Andersson, Alexandre M. Carmo, Maria I. Bokarewa. S100A4 regulates the Src-tyrosine kinase dependent differentiation of Th17 cells in rheumatoid arthritis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2014, 1842 (11) , 2049-2059. https://doi.org/10.1016/j.bbadis.2014.07.003
    22. Venkaiah Betapudi. Life without double-headed non-muscle myosin II motor proteins. Frontiers in Chemistry 2014, 2 https://doi.org/10.3389/fchem.2014.00045
    23. Annette Duelli, Bence Kiss, Ida Lundholm, Andrea Bodor, Maxim V. Petoukhov, Dmitri I. Svergun, László Nyitray, Gergely Katona, . The C-Terminal Random Coil Region Tunes the Ca2+-Binding Affinity of S100A4 through Conformational Activation. PLoS ONE 2014, 9 (5) , e97654. https://doi.org/10.1371/journal.pone.0097654
    24. Stephane R. Gross, Connie Goh Then Sin, Roger Barraclough, Philip S. Rudland. Joining S100 proteins and migration: for better or for worse, in sickness and in health. Cellular and Molecular Life Sciences 2014, 71 (9) , 1551-1579. https://doi.org/10.1007/s00018-013-1400-7
    25. Malin C. Erlandsson, Mattias D. Svensson, Ing-Marie Jonsson, Li Bian, Noona Ambartsumian, Sofia Andersson, ZhiQi Peng, Jukka Vääräniemi, Claes Ohlsson, Karin M.E. Andersson, Maria I. Bokarewa. Expression of metastasin S100A4 is essential for bone resorption and regulates osteoclast function. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2013, 1833 (12) , 2653-2663. https://doi.org/10.1016/j.bbamcr.2013.06.020
    26. Udupi A Ramagopal, Natalya G Dulyaninova, Kristen M Varney, Paul T Wilder, Sridevi Nallamsetty, Michael Brenowitz, David J Weber, Steven C Almo, Anne R Bresnick. Structure of the S100A4/myosin-IIA complex. BMC Structural Biology 2013, 13 (1) https://doi.org/10.1186/1472-6807-13-31
    27. Neil Billington, Aibing Wang, Jian Mao, Robert S. Adelstein, James R. Sellers. Characterization of Three Full-length Human Nonmuscle Myosin II Paralogs. Journal of Biological Chemistry 2013, 288 (46) , 33398-33410. https://doi.org/10.1074/jbc.M113.499848
    28. Natalya G Dulyaninova, Anne R Bresnick. The heavy chain has its day. BioArchitecture 2013, 3 (4) , 77-85. https://doi.org/10.4161/bioa.26133
    29. Mathias Dahlmann, Ulrike Sack, Pia Herrmann, Margit Lemm, Iduna Fichtner, Peter M. Schlag, Ulrike Stein. Systemic shRNA mediated knock-down of S100A4 in colorectal cancer xenografted mice reduces metastasis formation. Oncotarget 2012, 3 (8) , 783-797. https://doi.org/10.18632/oncotarget.572
    30. Min Du, Guozheng Wang, Thamir M. Ismail, Stephane Gross, David G. Fernig, Roger Barraclough, Philip S. Rudland. S100P Dissociates Myosin IIA Filaments and Focal Adhesion Sites to Reduce Cell Adhesion and Enhance Cell Migration. Journal of Biological Chemistry 2012, 287 (19) , 15330-15344. https://doi.org/10.1074/jbc.M112.349787
    31. Bence Kiss, Annette Duelli, László Radnai, Katalin A. Kékesi, Gergely Katona, László Nyitray. Crystal structure of the S100A4–nonmuscle myosin IIA tail fragment complex reveals an asymmetric target binding mechanism. Proceedings of the National Academy of Sciences 2012, 109 (16) , 6048-6053. https://doi.org/10.1073/pnas.1114732109
    32. Paul R. Elliott, Andrew F. Irvine, Hyun Suk Jung, Kaeko Tozawa, Martyna W. Pastok, Remigio Picone, Sandip K. Badyal, Jaswir Basran, Philip S. Rudland, Roger Barraclough, Lu-Yun Lian, Clive R. Bagshaw, Marina Kriajevska, Igor L. Barsukov. Asymmetric Mode of Ca2+-S100A4 Interaction with Nonmuscle Myosin IIA Generates Nanomolar Affinity Required for Filament Remodeling. Structure 2012, 20 (4) , 654-666. https://doi.org/10.1016/j.str.2012.02.002
    33. Ulrike Sack, Wolfgang Walther, Dominic Scudiero, Mike Selby, Jutta Aumann, Clara Lemos, Iduna Fichtner, Peter M. Schlag, Robert H. Shoemaker, Ulrike Stein, . S100A4-induced cell motility and metastasis is restricted by the Wnt/β-catenin pathway inhibitor calcimycin in colon cancer cells. Molecular Biology of the Cell 2011, 22 (18) , 3344-3354. https://doi.org/10.1091/mbc.e10-09-0739
    34. Connie Goh Then Sin, Nils Hersch, Philip S. Rudland, Roger Barraclough, Bernd Hoffmann, Stephane R. Gross. S100A4 downregulates filopodia formation through increased dynamic instability. Cell Adhesion & Migration 2011, 5 (5) , 439-447. https://doi.org/10.4161/cam.5.5.17773
    35. Reniqua P. House, Sarah C. Garrett, Anne R. Bresnick. Moving Aggressively: S100A4 and Tumor Invasion. 2011, 91-113. https://doi.org/10.1007/978-94-007-2558-4_4
    36. Sandip K. Badyal, Jaswir Basran, Nina Bhanji, Ju Hwan Kim, Alap P. Chavda, Hyun Suk Jung, Roger Craig, Paul R. Elliott, Andrew F. Irvine, Igor L. Barsukov, Marina Kriajevska, Clive R. Bagshaw. Mechanism of the Ca2+-Dependent Interaction between S100A4 and Tail Fragments of Nonmuscle Myosin Heavy Chain IIA. Journal of Molecular Biology 2011, 405 (4) , 1004-1026. https://doi.org/10.1016/j.jmb.2010.11.036
    37. Zhong-Hua Li, Natalya G. Dulyaninova, Reniqua P. House, Steven C. Almo, Anne R. Bresnick, . S100A4 Regulates Macrophage Chemotaxis. Molecular Biology of the Cell 2010, 21 (15) , 2598-2610. https://doi.org/10.1091/mbc.e09-07-0609
    38. Peter D. Chantler, Steven R. Wylie, Caroline P. Wheeler-Jones, Imelda M. McGonnell. Conventional myosins – unconventional functions. Biophysical Reviews 2010, 2 (2) , 67-82. https://doi.org/10.1007/s12551-010-0030-7
    39. Thamir M. Ismail, Shu Zhang, David G. Fernig, Stephane Gross, Marisa L. Martin-Fernandez, Violaine See, Kaeko Tozawa, Christopher J. Tynan, Guozheng Wang, Mark C. Wilkinson, Philip S. Rudland, Roger Barraclough. Self-association of Calcium-binding Protein S100A4 and Metastasis. Journal of Biological Chemistry 2010, 285 (2) , 914-922. https://doi.org/10.1074/jbc.M109.010892
    40. Tsutomu Inoue, Hirokazu Okada, Tsuneo Takenaka, Yusuke Watanabe, Hiromichi Suzuki. A case report suggesting the occurrence of epithelial–mesenchymal transition in obstructive nephropathy. Clinical and Experimental Nephrology 2009, 13 (4) , 385-388. https://doi.org/10.1007/s10157-009-0168-4
    41. Thamir M. Ismail, David G. Fernig, Philip S. Rudland, Carla J. Terry, Guozheng Wang, Roger Barraclough. The basic C-terminal amino acids of calcium-binding protein S100A4 promote metastasis. Carcinogenesis 2008, 29 (12) , 2259-2266. https://doi.org/10.1093/carcin/bgn217
    42. Mikael Schneider, Jakob L. Hansen, Søren P. Sheikh. S100A4: a common mediator of epithelial–mesenchymal transition, fibrosis and regeneration in diseases?. Journal of Molecular Medicine 2008, 86 (5) , 507-522. https://doi.org/10.1007/s00109-007-0301-3
    43. Mercedes Rey, Agustín Valenzuela-Fernández, Ana Urzainqui, María Yáñez-Mó, Manuel Pérez-Martínez, Petronila Penela, Federico Mayor, Francisco Sánchez-Madrid. Myosin IIA is involved in the endocytosis of CXCR4 induced by SDF-1α. Journal of Cell Science 2007, 120 (6) , 1126-1133. https://doi.org/10.1242/jcs.03415
    44. John Kolega, . The Role of Myosin II Motor Activity in Distributing Myosin Asymmetrically and Coupling Protrusive Activity to Cell Translocation. Molecular Biology of the Cell 2006, 17 (10) , 4435-4445. https://doi.org/10.1091/mbc.e06-05-0431
    45. Liliana Santamaria-Kisiel, Anne C. Rintala-Dempsey, Gary S. Shaw. Calcium-dependent and -independent interactions of the S100 protein family. Biochemical Journal 2006, 396 (2) , 201-214. https://doi.org/10.1042/BJ20060195
    46. Zhong-Hua Li, Anne R. Bresnick. The S100A4 Metastasis Factor Regulates Cellular Motility via a Direct Interaction with Myosin-IIA. Cancer Research 2006, 66 (10) , 5173-5180. https://doi.org/10.1158/0008-5472.CAN-05-3087
    47. Keizo Takenaga, Elena N. Kozlova. Role of intracellular S100A4 for migration of rat astrocytes. Glia 2006, 53 (3) , 313-321. https://doi.org/10.1002/glia.20284
    48. Sarah C. Garrett, Kristen M. Varney, David J. Weber, Anne R. Bresnick. S100A4, a Mediator of Metastasis. Journal of Biological Chemistry 2006, 281 (2) , 677-680. https://doi.org/10.1074/jbc.R500017200
    49. M Zou, R S Al-Baradie, H Al-Hindi, N R Farid, Y Shi. S100A4 (Mts1) gene overexpression is associated with invasion and metastasis of papillary thyroid carcinoma. British Journal of Cancer 2005, 93 (11) , 1277-1284. https://doi.org/10.1038/sj.bjc.6602856
    50. Fan Dong, Sufeng Li, Núria Pujol‐Moix, Naomi L. C. Luban, Sang Won Shin, Jae Hong Seo, Arlette Ruiz‐Saez, Judit Demeter, Scott Langdon, Michael J. Kelley. Genotype–phenotype correlation in MYH9‐related thrombocytopenia. British Journal of Haematology 2005, 130 (4) , 620-627. https://doi.org/10.1111/j.1365-2141.2005.05658.x
    51. Libor Kvítek, Robert Prucek. The preparation and application of silver nanoparticles. Journal of Materials Science 2005, https://doi.org/10.1007/s10853-005-0789-2
    52. Shu Zhang, Guozheng Wang, Dong Liu, Zhengzheng Bao, David G Fernig, Philip S Rudland, Roger Barraclough. The C-terminal region of S100A4 is important for its metastasis-inducing properties. Oncogene 2005, 24 (27) , 4401-4411. https://doi.org/10.1038/sj.onc.1208663
    53. Shu Zhang, Guozheng Wang, David G. Fernig, Philip S. Rudland, Stephen E. D. Webb, Roger Barraclough, Marisa Martin-Fernandez. Interaction of metastasis-inducing S100A4 protein in vivo by fluorescence lifetime imaging microscopy. European Biophysics Journal 2005, 34 (1) , 19-27. https://doi.org/10.1007/s00249-004-0428-x
    54. Martin Sandelin, Sheller Zabihi, Li Liu, Grzegorz Wicher, Elena N. Kozlova. Metastasis‐associated S100A4 (Mts1) protein is expressed in subpopulations of sensory and autonomic neurons and in Schwann cells of the adult rat. Journal of Comparative Neurology 2004, 473 (2) , 233-243. https://doi.org/10.1002/cne.20115
    55. Jordan Jacobelli, Stephen A Chmura, Denis B Buxton, Mark M Davis, Matthew F Krummel. A single class II myosin modulates T cell motility and stopping, but not synapse formation. Nature Immunology 2004, 5 (5) , 531-538. https://doi.org/10.1038/ni1065
    56. Michael E. Brown, Paul C. Bridgman. Myosin function in nervous and sensory systems. Journal of Neurobiology 2004, 58 (1) , 118-130. https://doi.org/10.1002/neu.10285
    57. Eliahu Golomb, Xuefei Ma, Siddhartha S. Jana, Yvette A. Preston, Sachiyo Kawamoto, Nitza G. Shoham, Ehud Goldin, Mary Anne Conti, James R. Sellers, Robert S. Adelstein. Identification and Characterization of Nonmuscle Myosin II-C, a New Member of the Myosin II Family. Journal of Biological Chemistry 2004, 279 (4) , 2800-2808. https://doi.org/10.1074/jbc.M309981200
    58. Edward J. Kim, David M. Helfman. Characterization of the Metastasis-associated Protein, S100A4. Journal of Biological Chemistry 2003, 278 (32) , 30063-30073. https://doi.org/10.1074/jbc.M304909200
    59. Nathalie Belot, Roland Pochet, Claus W Heizmann, Robert Kiss, Christine Decaestecker. Extracellular S100A4 stimulates the migration rate of astrocytic tumor cells by modifying the organization of their actin cytoskeleton. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 2002, 1600 (1-2) , 74-83. https://doi.org/10.1016/S1570-9639(02)00447-8
    60. Elena N. Kozlova, Eugene Lukanidin. Mts1 protein expression in the central nervous system after injury. Glia 2002, 37 (4) , 337-348. https://doi.org/10.1002/glia.10045
    61. Luca Mazzucchelli. Protein S100A4: Too Long Overlooked by Pathologists?. The American Journal of Pathology 2002, 160 (1) , 7-13. https://doi.org/10.1016/S0002-9440(10)64342-8
    62. Hai-lan Chen, David G. Fernig, Philip S. Rudland, Alison Sparks, Mark C. Wilkinson, Roger Barraclough. Binding to Intracellular Targets of the Metastasis-Inducing Protein, S100A4 (p9Ka). Biochemical and Biophysical Research Communications 2001, 286 (5) , 1212-1217. https://doi.org/10.1006/bbrc.2001.5517
    63. Mitsuo Ikebe, Satoshi Komatsu, John L. Woodhead, Katsuhide Mabuchi, Reiko Ikebe, Junya Saito, Roger Craig, Masaaki Higashihara. The Tip of the Coiled-coil Rod Determines the Filament Formation of Smooth Muscle and Nonmuscle Myosin. Journal of Biological Chemistry 2001, 276 (32) , 30293-30300. https://doi.org/10.1074/jbc.M101969200
    64. Marina Kriajevska, Igor B. Bronstein, David J. Scott, Svetlana Tarabykina, Margrethe Fischer-Larsen, Olaf-Georg Issinger, Eugene Lukanidin. Metastasis-associated protein Mts1 (S100A4) inhibits CK2-mediated phosphorylation and self-assembly of the heavy chain of nonmuscle myosin. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2000, 1498 (2-3) , 252-263. https://doi.org/10.1016/S0167-4889(00)00100-2
    65. . Epilogue. 2000https://doi.org/10.1201/NOE0849309823.bmatt
    66. Denis B. Buxton, Robert S. Adelstein. Calcium-dependent Threonine Phosphorylation of Nonmuscle Myosin in Stimulated RBL-2H3 Mast Cells. Journal of Biological Chemistry 2000, 275 (44) , 34772-34779. https://doi.org/10.1074/jbc.M004996200
    67. Fredrik ?berg, Elena N. Kozlova. Metastasis-associated Mts1 (S100A4) protein in the developing and adult central nervous system. The Journal of Comparative Neurology 2000, 424 (2) , 269-282. https://doi.org/10.1002/1096-9861(20000821)424:2<269::AID-CNE6>3.0.CO;2-M
    68. Guozheng Wang, Philip S. Rudland, Michael R. White, Roger Barraclough. Interaction in Vivo and in Vitro of the Metastasis-inducing S100 Protein, S100A4 (p9Ka) with S100A1. Journal of Biological Chemistry 2000, 275 (15) , 11141-11146. https://doi.org/10.1074/jbc.275.15.11141
    69. Anna M. Sokac, William M. Bement. Regulation and expression of metazoan unconventional myosins. 2000, 197-304. https://doi.org/10.1016/S0074-7696(00)00005-X
    70. Anne R Bresnick. Molecular mechanisms of nonmuscle myosin-II regulation. Current Opinion in Cell Biology 1999, 11 (1) , 26-33. https://doi.org/10.1016/S0955-0674(99)80004-0
    71. Roger Barraclough. Calcium-binding protein S100A4 in health and disease. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1998, 1448 (2) , 190-199. https://doi.org/10.1016/S0167-4889(98)00143-8
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