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Information on EC 1.3.3.4 - protoporphyrinogen oxidase

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EC Tree
     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.3 With oxygen as acceptor
                1.3.3.4 protoporphyrinogen oxidase
IUBMB Comments
This is the last common enzyme in the biosynthesis of chlorophylls and heme . Two isoenzymes exist in plants: one in plastids and the other in mitochondria. This is the target enzyme of phthalimide-type and diphenylether-type herbicides . The enzyme from oxygen-dependent species contains FAD . Also slowly oxidizes mesoporphyrinogen IX.
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Word Map
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
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protoporphyrinogen IX
+
3
O2
=
protoporphyrin IX
+
3
H2O2
+
3
=
+
3
Synonyms
protoporphyrinogen oxidase, ppox, protox, protoporphyrinogen ix oxidase, mtppo, protox enzyme, protoporphyrinogen oxidase ix, ppo1-1, ppox i, protein yfex, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2
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