Abstract
Background: It is widely accepted that chronic inflammation critically contributes to cancer. Immune tolerance in cancer mediates tumor escape from the immune system. The mechanisms of relations between inflammation and immune tolerance are still not fully elucidated.
Objective: The main mechanisms that link inflammation and tolerance are considered. Drug targets that are in use to interfere with inflammation in cancer are discussed. Conclusion: Inflammation mediates tumor-induced tolerance. The induction and the maintenance of the chronic inflammatory response is a universal mechanism of immune tolerance.Keywords: Inflammation, resolution, immune tolerance, cancer immunotherapy, tumor immunology, tumor-induced tolerance.
Current Cancer Drug Targets
Title:The Linkage Between Inflammation and Immune Tolerance: Interfering with Inflammation in Cancer
Volume: 17 Issue: 4
Author(s): Vladimir Stanislavovich Rogovskii*
Affiliation:
- Department of Molecular Pharmacology and Radiobiology, Pirogov Russian National Research Medical University, Bolshaya Pirogovskaya st. 9a, Moscow, 119435,Russian Federation
Keywords: Inflammation, resolution, immune tolerance, cancer immunotherapy, tumor immunology, tumor-induced tolerance.
Abstract: Background: It is widely accepted that chronic inflammation critically contributes to cancer. Immune tolerance in cancer mediates tumor escape from the immune system. The mechanisms of relations between inflammation and immune tolerance are still not fully elucidated.
Objective: The main mechanisms that link inflammation and tolerance are considered. Drug targets that are in use to interfere with inflammation in cancer are discussed. Conclusion: Inflammation mediates tumor-induced tolerance. The induction and the maintenance of the chronic inflammatory response is a universal mechanism of immune tolerance.Export Options
About this article
Cite this article as:
Rogovskii Stanislavovich Vladimir*, The Linkage Between Inflammation and Immune Tolerance: Interfering with Inflammation in Cancer, Current Cancer Drug Targets 2017; 17 (4) . https://dx.doi.org/10.2174/1568009617666170109110816
DOI https://dx.doi.org/10.2174/1568009617666170109110816 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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