Entry
Name
3-hydroxy-2-methylbutyryl-CoA dehydrogenase;
2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase;
2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase;
2-methyl-3-hydroxy-butyryl CoA dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptorBRITE hierarchy
Sysname
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase
Reaction(IUBMB)
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD+ = 2-methylacetoacetyl-CoA + NADH + H+ [RN:
R04203 ]
Reaction(KEGG)
Substrate
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA [CPD:
C04405 ];
NAD+ [CPD:
C00003 ]
Product
Comment
Also acts, more slowly, on (2S,3S)-2-hydroxy-3-methylpentanoyl-CoA.
History
EC 1.1.1.178 created 1981
Pathway
ec00280
Valine, leucine and isoleucine degradation
ec01110
Biosynthesis of secondary metabolites
Orthology
K08683
3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase
Genes
CSAB :
103232017(HSD17B10)
CATY :
105576369(HSD17B10)
PANU :
101012016(HSD17B10)
MLEU :
105532263(HSD17B10)
TFN :
117078288(HSD17B10) 117091873
PTEH :
111531744(HSD17B10)
CANG :
105514907(HSD17B10)
CIMI :
108295447(HSD17B10)
CSYR :
103253700(HSD17B10)
LCAT :
123628032(HSD17B10) 123635438
PCOQ :
105823442(HSD17B10)
MCAL :
110286767(Hsd17b10)
MPAH :
110313838(Hsd17b10)
MCOC :
116089853(Hsd17b10)
MAUA :
101837486(Hsd17b10)
PROB :
127217690(Hsd17b10) 127231134
PLEU :
114683399 114702840(Hsd17b10)
MORG :
121443092 121445568(Hsd17b10)
AAMP :
119804867(Hsd17b10) 119819446
CPOC :
100718814(Hsd17b10)
CCAN :
109702046(Hsd17b10)
DORD :
106000637(Hsd17b10)
PLOP :
125344092(Hsd17b10)
MMMA :
107159874(Hsd17b10)
CLUD :
112673073(HSD17B10)
MPUF :
101693030(HSD17B10)
NVS :
122894392 122896272(HSD17B10) 122916941
PCOO :
112870930(HSD17B10)
PVIV :
125157292(HSD17B10)
PPAD :
109260276(HSD17B10)
BBUB :
102403269(HSD17B10)
BBIS :
105000965(HSD17B10)
BTAX :
128070049(HSD17B10)
ODA :
120851531 120854550 120860174 120882164(HSD17B10)
CCAD :
122434299(HSD17B10)
MBEZ :
129564227(HSD17B10)
CFR :
102504376(HSD17B10) 102511542
CBAI :
105081500(HSD17B10)
BACU :
103010500(HSD17B10)
BMUS :
118889266(HSD17B10)
PCAD :
102982939(HSD17B10)
PSIU :
116747313(HSD17B10)
NASI :
112408416(HSD17B10)
MMYO :
118653717(HSD17B10) 118659315
PKL :
118706130 118706176 118714042(HSD17B10)
EFUS :
103294936 103301347(HSD17B10)
SHON :
118978337(HSD17B10)
PDIC :
114505044(HSD17B10)
PHAS :
123814830(HSD17B10)
PPAM :
129064545(HSD17B10) 129075737
PALE :
102882756(HSD17B10)
PGIG :
120593567(HSD17B10)
SARA :
101554831(HSD17B10)
SETR :
125999256(HSD17B10)
ETF :
101643918 101654022(HSD17B10)
DNM :
101437023 101443695(HSD17B10)
PCOC :
116240178(HSD17B10)
NMEL :
110391433(HSD17B10)
PMOA :
120503076(HSD17B10)
PRUF :
121362366(HSD17B10)
PMAJ :
107199346(HSD17B10)
CBRC :
103617130(HSD17B10)
MMEA :
130586734(HSD17B10)
ACHC :
115338221(HSD17B10)
SHAB :
115603483(HSD17B10)
PGUU :
104460485(HSD17B10)
CUCA :
104067759(HSD17B10)
AROW :
112972653(HSD17B10)
CCAY :
125628021(HSD17B10)
CPIC :
101946623(HSD17B10)
CABI :
116818886(HSD17B10)
ASAO :
132767863(HSD17B10)
SUND :
121922707(HSD17B10)
PMUR :
107284213(HSD17B10)
CTIG :
120311302(HSD17B10)
PGUT :
117675536(HSD17B10)
APRI :
131192205(HSD17B10)
PTEX :
113443230(HSD17B10)
PMUA :
114588150(HSD17B10)
PRAF :
128404927(HSD17B10) 128406171
XLA :
108699982(hsd17b10.S) 446903(hsd17b10.L)
RTEM :
120913022(HSD17B10)
BBUF :
121009152(HSD17B10)
BGAR :
122946398(HSD17B10)
SANH :
107656989 107672063(hsd17b10)
CAUA :
113069104(hsd17b10) 113094765
CGIB :
127944159 128011065
PTET :
122329266(hsd17b10)
LROH :
127155270(hsd17b10)
PPRM :
120463755(hsd17b10)
MAMB :
125260492(hsd17b10)
MASI :
127419442 127420442
TROS :
130544981(hsd17b10)
MANU :
129431225(hsd17b10)
PHYP :
113530295(hsd17b10)
SMEO :
124398597(hsd17b10)
AMEX :
103024621(hsd17b10)
CMAO :
118822580(hsd17b10)
CHAR :
105894129(hsd17b10)
TBEN :
117483467(hsd17b10) 117483479 117483535
CGOB :
115011423(hsd17b10)
PGEO :
117449563(hsd17b10)
GACU :
117562352(hsd17b10)
EMAC :
134871417(hsd17b10)
PLEP :
121947111(hsd17b10)
SLUC :
116059325(hsd17b10)
ECRA :
117948109(hsd17b10)
PFLV :
114559071(hsd17b10)
PPUG :
119223392(hsd17b10)
CLUM :
117733173(hsd17b10) 117733856
PSWI :
130199841(hsd17b10)
MSAM :
119905089(hsd17b10)
SCHU :
122882575(hsd17b10)
ALAT :
119022692(hsd17b10)
CSAI :
133456220(hsd17b10)
XMA :
102219644(hsd17b10) 111608152
XHE :
116717817(hsd17b10) 116717849 116720286
PRET :
103467892(hsd17b10)
PFOR :
103130892(hsd17b10)
PLAI :
106960803(hsd17b10)
PMEI :
106932965(hsd17b10)
PPRL :
129377107(hsd17b10)
CTUL :
119799317(hsd17b10)
ALIM :
106511017(hsd17b10)
MCEP :
125023683(hsd17b10)
CSEM :
103385214(hsd17b10)
SSEN :
122761722(hsd17b10)
HHIP :
117765000(hsd17b10)
SMAU :
118316978(hsd17b10)
SLAL :
111644152(hsd17b10)
SBIA :
133505115(hsd17b10)
PTAO :
133477268(hsd17b10)
BPEC :
110175804(hsd17b10)
MALB :
109951871(hsd17b10)
BSPL :
114859022(hsd17b10)
SASA :
100196585(hsd17b10)
STRU :
115168753(hsd17b10)
SALP :
112075320(hsd17b10)
CCLU :
121546823(hsd17b10)
AANG :
118207783(hsd17b10)
PSPA :
121305366(hsd17b10)
PSEX :
120542716(hsd17b10)
CPLA :
122542360(hsd17b10)
PMRN :
116952231(HSD17B10)
SCLV :
120327902 120331757
LPIC :
129257317 129257335
DSI :
Dsimw501_GD17383(Dsim_GD17383)
AALB :
109427471 109427473 109427541 115253538 115253659 115269370
CQU :
CpipJ_CPIJ014285 CpipJ_CPIJ014286
CPII :
120420167 120420202
CNS :
116340896 116341640 116347922 116347923 116348465 116348677 116352597
BCOO :
119077639 119083641
ALAB :
122710550 122711460
AFLR :
100867464 100871693
BBIF :
117206297 117207552 117207654
BVAN :
117153343 117156912
BTER :
100642257 100652075 100652169
BAFF :
126917491 126917492 126917494 126922587
BPYO :
122569073 122569811 122572480 122572547
BPAS :
132907124 132916712
MGEN :
117223643 117223858
NMEA :
116425158 116425159 116425336
CGIG :
122395028 122399651
ACEP :
105623752 105623755
PFUC :
122524227 122525451 122525452
VCRB :
124430227 124430228
TPRE :
106653412 106653557
CGLO :
123267606 123270676
DAM :
107042858 107047511 107047998
AGIF :
122853371 122855531 122855533 122856582
CINS :
118071768 118073789
VCAN :
122406472 122417374
DPA :
109539142 109542618 109543344 109546870
SOY :
115885943 115885955 115888479
AGRG :
126735339 126739758 126743681
CSET :
123312088 123321083
BMAN :
114239449 114246883
MSEX :
115440509 115442905
DPL :
KGM_206141 KGM_207362
BANY :
112048026 112053858
MCIX :
123664193 123668706
PMAC :
106719897 106721132
PPOT :
106103284 106104281
PRAP :
110993036 111000559
PNAP :
125053857 125062863
CCRC :
123700762 123705454
LSIN :
126975470 126978561
AAGE :
121735759 121738572
TNL :
113494026 113499310 113499443
SLIU :
111348796 111360581
CFEL :
113381984 113382094 113382095
TPAL :
117650272 117651916
SGRE :
126339020 126339036
HAME :
121875227 121875315
DPTE :
113791783 113798578
DFR :
124490400 124498538 124499261
CSCU :
111628029 111640538
PTEP :
107443400 107443407 107444042 107444043
ABRU :
129963812 129964069 129964070
UDV :
129217412 129217414 129217417
SDM :
118183746 118187370 118193954 118193955 118193956
PMEO :
129583335 129583377 129584270 129584271 129586187 129589768 129589791 129589810 129589832 129592188 129598566
CBR :
CBG_06017(Cbr-ard-1)
CRQ :
GCK72_014065 GCK72_014228
BMY :
BM_BM3137(Bma-ard-1.1) BM_BM3231(Bma-ard-1.2)
LOA :
LOAG_02590 LOAG_02591
LGI :
LOTGIDRAFT_130767 LOTGIDRAFT_130874
CVN :
111106365 111108694 111109578 111109751
CANU :
128157694 128159502 128161110
ATEN :
116304314 116304315
SPIS :
111326563 111327200
TAD :
TRIADDRAFT_22420 TRIADDRAFT_51183
ABP :
AGABI1DRAFT119037(AGABI1DRAFT_119037)
MRR :
Moror_1115 Moror_1116
WSE :
WALSEDRAFT_66965 WALSEDRAFT_66966
TET :
TTHERM_00085280 TTHERM_00085290 TTHERM_00085300 TTHERM_00085310
ยป show all Taxonomy
Reference
Authors
Conrad RS, Massey LK, Sokatch JR.
Title
D- and L-isoleucine metabolism and regulation of their pathways in Pseudomonas putida.
Journal
Other DBs
ExPASy - ENZYME nomenclature database:
1.1.1.178