KEGG     ENZYME: 1.1.1.178
Entry
EC 1.1.1.178                Enzyme                                 
Name
3-hydroxy-2-methylbutyryl-CoA dehydrogenase;
2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase;
2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase;
2-methyl-3-hydroxy-butyryl CoA dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase
Reaction(IUBMB)
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD+ = 2-methylacetoacetyl-CoA + NADH + H+ [RN:R04203]
Reaction(KEGG)
R04203
Substrate
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA [CPD:C04405];
NAD+ [CPD:C00003]
Product
2-methylacetoacetyl-CoA [CPD:C03344];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Also acts, more slowly, on (2S,3S)-2-hydroxy-3-methylpentanoyl-CoA.
History
EC 1.1.1.178 created 1981
Pathway
ec00280   Valine, leucine and isoleucine degradation
ec01100   Metabolic pathways
ec01110   Biosynthesis of secondary metabolites
Orthology
K08683   3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase
Genes
HSA 3028(HSD17B10)
PTR 465649(HSD17B10)
PPS 100971848(HSD17B10)
GGO 101130538(HSD17B10)
PON 100459385(HSD17B10)
NLE 100594310(HSD17B10)
HMH 116811708(HSD17B10)
MCC 700018(HSD17B10)
MCF 102123916(HSD17B10)
MTHB 126946552
MNI 105493784(HSD17B10)
CSAB 103232017(HSD17B10)
CATY 105576369(HSD17B10)
PANU 101012016(HSD17B10)
TGE 112616408(HSD17B10)
MLEU 105532263(HSD17B10)
RRO 104663370(HSD17B10)
RBB 108520302(HSD17B10)
TFN 117078288(HSD17B10) 117091873
PTEH 111531744(HSD17B10)
CANG 105514907(HSD17B10)
CJC 100402832(HSD17B10)
SBQ 101039788(HSD17B10)
CIMI 108295447(HSD17B10)
CSYR 103253700(HSD17B10)
MMUR 105861240
LCAT 123628032(HSD17B10) 123635438
PCOQ 105823442(HSD17B10)
OGA 100940377(HSD17B10)
MMU 15108(Hsd17b10)
MCAL 110286767(Hsd17b10)
MPAH 110313838(Hsd17b10)
RNO 63864(Hsd17b10)
MCOC 116089853(Hsd17b10)
ANU 117694035(Hsd17b10)
MUN 110540816(Hsd17b10)
CGE 100757689(Hsd17b10)
MAUA 101837486(Hsd17b10)
PROB 127217690(Hsd17b10) 127231134
PLEU 114683399 114702840(Hsd17b10)
MORG 121443092 121445568(Hsd17b10)
MFOT 126494035
AAMP 119804867(Hsd17b10) 119819446
NGI 103747316(Hsd17b10)
HGL 101712281(Hsd17b10)
CPOC 100718814(Hsd17b10)
CCAN 109702046(Hsd17b10)
DORD 106000637(Hsd17b10)
DSP 122112017(Hsd17b10)
PLOP 125344092(Hsd17b10)
NCAR 124972561
MMMA 107159874(Hsd17b10)
OCU 100342235
OPI 101529823(HSD17B10)
TUP 102491700(HSD17B10)
GVR 103592126(HSD17B10)
CFA 480930(HSD17B10)
CLUD 112673073(HSD17B10)
VVP 112911953(HSD17B10)
VLG 121482238(HSD17B10)
NPO 129518320(HSD17B10)
AML 100483379(HSD17B10)
UMR 103675231(HSD17B10)
UAH 113247518(HSD17B10)
UAR 123793530(HSD17B10)
ELK 111139811
LLV 125092362
MPUF 101693030(HSD17B10)
MNP 132007269(HSD17B10)
MLK 131822124(HSD17B10)
NVS 122894392 122896272(HSD17B10) 122916941
ORO 101369544(HSD17B10)
EJU 114200638(HSD17B10)
ZCA 113931211(HSD17B10)
MLX 117998525(HSD17B10)
NSU 110588558(HSD17B10)
LWW 102733441(HSD17B10)
FCA 101090672(HSD17B10)
PYU 121024801(HSD17B10)
PCOO 112870930(HSD17B10)
PBG 122477514(HSD17B10)
PVIV 125157292(HSD17B10)
LRUF 124522283
PTG 102956982(HSD17B10)
PPAD 109260276(HSD17B10)
PUC 125931707
AJU 106985377
HHV 120222963(HSD17B10)
BTA 281809(HSD17B10)
BOM 102284367(HSD17B10)
BIU 109555307(HSD17B10)
BBUB 102403269(HSD17B10)
BBIS 105000965(HSD17B10)
CHX 102182021(HSD17B10)
OAS 101119880(HSD17B10)
BTAX 128070049(HSD17B10)
ODA 120851531 120854550 120860174 120882164(HSD17B10)
CCAD 122434299(HSD17B10)
MBEZ 129564227(HSD17B10)
SSC 100524293(HSD17B10)
CFR 102504376(HSD17B10) 102511542
CBAI 105081500(HSD17B10)
CDK 105096695(HSD17B10)
VPC 102531602(HSD17B10)
BACU 103010500(HSD17B10)
BMUS 118889266(HSD17B10)
LVE 103085758(HSD17B10)
OOR 101287041(HSD17B10)
DLE 111170779(HSD17B10)
PCAD 102982939(HSD17B10)
PSIU 116747313(HSD17B10)
NASI 112408416(HSD17B10)
ECB 100060335(HSD17B10)
EPZ 103542953(HSD17B10)
EAI 106822166(HSD17B10)
MYB 102241897
MYD 102751672(HSD17B10)
MMYO 118653717(HSD17B10) 118659315
MLF 102417112(HSD17B10)
PKL 118706130 118706176 118714042(HSD17B10)
EFUS 103294936 103301347(HSD17B10)
MNA 107542354(HSD17B10)
DRO 112322468(HSD17B10)
SHON 118978337(HSD17B10)
AJM 119055505(HSD17B10)
PDIC 114505044(HSD17B10)
PHAS 123814830(HSD17B10)
MMF 118635833(HSD17B10)
PPAM 129064545(HSD17B10) 129075737
HAI 109396389(HSD17B10)
RFQ 117021353(HSD17B10)
PALE 102882756(HSD17B10)
PGIG 120593567(HSD17B10)
PVP 105307806(HSD17B10)
RAY 107506614(HSD17B10)
MJV 108393376(HSD17B10)
TOD 119246140(HSD17B10)
SARA 101554831(HSD17B10)
SETR 125999256(HSD17B10)
LAV 100676457(HSD17B10)
TMU 101360197
ETF 101643918 101654022(HSD17B10)
DNM 101437023 101443695(HSD17B10)
MDO 100019657(HSD17B10)
GAS 123253957(HSD17B10)
SHR 100918332(HSD17B10)
AFZ 127542698
PCW 110201063(HSD17B10)
OAA 100081790(HSD17B10)
GGA 425758(HSD17B10)
PCOC 116240178(HSD17B10)
MGP 100540780(HSD17B10)
NMEL 110391433(HSD17B10)
LSR 110482653(HSD17B10)
PMOA 120503076(HSD17B10)
OTC 121340067(HSD17B10)
PRUF 121362366(HSD17B10)
OMA 130262830(HSD17B10)
PHI 102108549(HSD17B10)
PMAJ 107199346(HSD17B10)
CCW 120412192(HSD17B10)
CBRC 103617130(HSD17B10)
SVG 106864400(HSD17B8)
MMEA 130586734(HSD17B10)
HRT 120748218(HSD17B10)
FPG 101922240(HSD17B10)
FCH 102045831(HSD17B10)
ACHC 115338221(HSD17B10)
HLE 104834323(HSD17B10)
AGEN 126035190
SHAB 115603483(HSD17B10)
PGUU 104460485(HSD17B10)
CVF 104291634(HSD17B10)
CUCA 104067759(HSD17B10)
AROW 112972653(HSD17B10)
NPD 112946761(HSD17B10)
DNE 112985485(HSD17B10)
ASN 102377997(HSD17B10)
AMJ 102559608(HSD17B10)
CMY 102935413(HSD17B10)
CCAY 125628021(HSD17B10)
DCC 119847007(HSD17B10)
CPIC 101946623(HSD17B10)
CABI 116818886(HSD17B10)
MRV 120388542(HSD17B10)
ACS 100566347(hsd17b10)
ASAO 132767863(HSD17B10)
PVT 110089193(HSD17B10)
SUND 121922707(HSD17B10)
PBI 103051793(HSD17B10)
PMUR 107284213(HSD17B10)
CTIG 120311302(HSD17B10)
PGUT 117675536(HSD17B10)
APRI 131192205(HSD17B10)
PTEX 113443230(HSD17B10)
NSS 113417676(HSD17B10)
VKO 123030114(HSD17B10)
PMUA 114588150(HSD17B10)
PRAF 128404927(HSD17B10) 128406171
ZVI 118097678(HSD17B10)
HCG 128344203(HSD17B10)
GJA 107117365(HSD17B10)
EMC 129346280(HSD17B10)
XLA 108699982(hsd17b10.S) 446903(hsd17b10.L)
XTR 549265(hsd17b10)
NPR 108797529(HSD17B10)
RTEM 120913022(HSD17B10)
BBUF 121009152(HSD17B10)
BGAR 122946398(HSD17B10)
MUO 115463597(HSD17B10)
GSH 117349060(HSD17B10)
DRE 450078(hsd17b10)
SRX 107737644 107741341
SANH 107656989 107672063(hsd17b10)
SGH 107560905 107562460
CAUA 113069104(hsd17b10) 113094765
CGIB 127944159 128011065
PTET 122329266(hsd17b10)
LROH 127155270(hsd17b10)
OMC 131532057(hsd17b10)
PPRM 120463755(hsd17b10)
RKG 130081712(hsd17b10)
MAMB 125260492(hsd17b10)
CIDE 127505258
MASI 127419442 127420442
TROS 130544981(hsd17b10)
TDW 130409300(hsd17b10)
MANU 129431225(hsd17b10)
IPU 100528090(hsd17b10)
IFU 128619628(hsd17b10)
PHYP 113530295(hsd17b10)
SMEO 124398597(hsd17b10)
TFD 113642024(hsd17b10)
TVC 132862612(hsd17b10)
AMEX 103024621(hsd17b10)
CMAO 118822580(hsd17b10)
EEE 113575440(hsd17b10)
CHAR 105894129(hsd17b10)
TFS 130529577(hsd17b10)
TNG GSTEN00023338G001
LCO 104928358(hsd17b10)
TBEN 117483467(hsd17b10) 117483479 117483535
CGOB 115011423(hsd17b10)
PGEO 117449563(hsd17b10)
GACU 117562352(hsd17b10)
EMAC 134871417(hsd17b10)
ELY 117258246(hsd17b10)
EFO 125891170(hsd17b10)
PLEP 121947111(hsd17b10)
SLUC 116059325(hsd17b10)
ECRA 117948109(hsd17b10)
ESP 116692997(hsd17b10)
PFLV 114559071(hsd17b10)
GAT 120829460(hsd17b10)
PPUG 119223392(hsd17b10)
AFB 129100181(hsd17b10)
CLUM 117733173(hsd17b10) 117733856
PSWI 130199841(hsd17b10)
MSAM 119905089(hsd17b10)
SCHU 122882575(hsd17b10)
CUD 121517639(hsd17b10)
ALAT 119022692(hsd17b10)
MZE 101486814(hsd17b10)
ONL 100708936(hsd17b10)
OAU 116309184(hsd17b10)
OLA 101170516(hsd17b10)
OML 112159416(hsd17b10)
CSAI 133456220(hsd17b10)
XMA 102219644(hsd17b10) 111608152
XCO 114141158(hsd17b10)
XHE 116717817(hsd17b10) 116717849 116720286
PRET 103467892(hsd17b10)
PFOR 103130892(hsd17b10)
PLAI 106960803(hsd17b10)
PMEI 106932965(hsd17b10)
GAF 122835328(hsd17b10)
PPRL 129377107(hsd17b10)
CVG 107088734(hsd17b10)
CTUL 119799317(hsd17b10)
GMU 124877059(hsd17b10)
NFU 107390369(hsd17b10)
KMR 108230534(hsd17b10)
ALIM 106511017(hsd17b10)
NWH 119416676(hsd17b10)
MCEP 125023683(hsd17b10)
CSEM 103385214(hsd17b10)
POV 109646243(hsd17b10)
SSEN 122761722(hsd17b10)
HHIP 117765000(hsd17b10)
HSP 118111521(hsd17b10)
SMAU 118316978(hsd17b10)
LCF 108875474
SDU 111235061(hsd17b10)
SLAL 111644152(hsd17b10)
XGL 120803441(hsd17b10)
HCQ 109523116(hsd17b10)
SSCV 125989420
SBIA 133505115(hsd17b10)
PEE 133396423(hsd17b10)
PTAO 133477268(hsd17b10)
BPEC 110175804(hsd17b10)
MALB 109951871(hsd17b10)
BSPL 114859022(hsd17b10)
SJO 128357055(hsd17b10)
SASA 100196585(hsd17b10)
STRU 115168753(hsd17b10)
OTW 112221480(hsd17b10)
OMY 110492729(hsd17b10)
OGO 124045434(hsd17b10)
ONE 115126100
OKI 109885832(hsd17b10)
OKE 118360242
SALP 112075320(hsd17b10)
SNH 120037698(hsd17b10)
CCLU 121546823(hsd17b10)
ELS 105013512(hsd17b10)
SFM 108918316(hsd17b10)
PKI 111857098(hsd17b10)
AANG 118207783(hsd17b10)
PSPA 121305366(hsd17b10)
PSEX 120542716(hsd17b10)
LCM 102359593(HSD17B10)
RTP 109920085(hsd17b10)
CPLA 122542360(hsd17b10)
HOC 132809036(hsd17b10)
PMRN 116952231(HSD17B10)
LRJ 133355481 133355602
BFO 118415771
BBEL 109477394
CIN 100180343
SCLV 120327902 120331757
SPU 579135
LPIC 129257317 129257335
APLC 110974895
AJC 117115542
SKO 100374978
DME Dmel_CG7113(scu)
DER 6550269
DSE 6614820
DSI Dsimw501_GD17383(Dsim_GD17383)
DYA Dyak_GE17707
DAN 6502128
DSR 110184295
DPO 4814601
DPE 6599292
DMN 108156573
DWI 6648649
DGR 6565878
DMO Dmoj_GI14682
DAZ 108619639
DNV 108657245
DHE 111602401
DVI 6633483
CCAT 101454723
BOD 106615670
BDR 105227468
RZE 108371357 108376016
AOQ 129238945
TDA 119670822
MDE 101893864
SCAC 106081076
LCQ 111678909
LSQ 119606776
GFS 119638479
ECOE 129947661
CLON 129613368
HIS 119646612
AGA 1272787
ACOZ 120949516
AARA 120897970
AMER 121591078
ASTE 118506790
AFUN 125775105
AMOU 128299231
AALI 118457824
AAG 5571801 5571804
AALB 109427471 109427473 109427541 115253538 115253659 115269370
CQU CpipJ_CPIJ014285 CpipJ_CPIJ014286
CPII 120420167 120420202
CNS 116340896 116341640 116347922 116347923 116348465 116348677 116352597
BCOO 119077639 119083641
AME 725274 726590
ALAB 122710550 122711460
ADR 102670881 102673042
AFLR 100867464 100871693
BIM 100744954 100745932
BBIF 117206297 117207552 117207654
BVK 117233088 117236101
BVAN 117153343 117156912
BTER 100642257 100652075 100652169
BAFF 126917491 126917492 126917494 126922587
BPYO 122569073 122569811 122572480 122572547
BPAS 132907124 132916712
FVI 122535016 122535905
CCAL 108632372
OBB 114872622 114881413
OLG 117607659 117609087
MGEN 117223643 117223858
NMEA 116425158 116425159 116425336
CGIG 122395028 122399651
SOC 105205705 120356835
MPHA 105840130
AEC 105144619 105147099
ACEP 105623752 105623755
PBAR 105431577
VEM 105565701
HST 105184127
DQU 106748723
CFO 105248305
FEX 115245137
LHU 105674362
PGC 109854144
OBO 105283150
PCF 106789194 106791582
PFUC 122524227 122525451 122525452
VPS 122634700 122634701
VCRB 124430227 124430228
VVE 124954848 124954849
NVI 100114736
CSOL 105363298
TPRE 106653412 106653557
LHT 122499182
LBD 127281908
MDL 103575367 103575716
CGLO 123267606 123270676
FAS 105264291
DAM 107042858 107047511 107047998
AGIF 122853371 122855531 122855533 122856582
CINS 118071768 118073789
VCAN 122406472 122417374
CCIN 107263357
DSM 124404017
NPT 124211958
NFB 124174619
NLO 107224820
NVG 124297908
AROA 105689327
TCA 660648
DPA 109539142 109542618 109543344 109546870
SOY 115885943 115885955 115888479
AGRG 126735339 126739758 126743681
ATD 109596271
CSET 123312088 123321083
AGB 108916550
LDC 111508946
NVL 108566047
APLN 108742099
PPYR 116180131
OTU 111425860
BMOR 101744555 732961
BMAN 114239449 114246883
MSEX 115440509 115442905
DPL KGM_206141 KGM_207362
BANY 112048026 112053858
MJU 123876904 123880125
NIQ 126776519 126780464
VCD 124538772 124543010
MCIX 123664193 123668706
PMAC 106719897 106721132
PPOT 106103284 106104281
PXU 106113640 106116574
PRAP 110993036 111000559
PBX 123710398 123718779
PNAP 125053857 125062863
ZCE 119828938 119835635
CCRC 123700762 123705454
LSIN 126975470 126978561
AAGE 121735759 121738572
HAW 110371359 110373884
HZE 124640969 124645237
TNL 113494026 113499310 113499443
SLIU 111348796 111360581
OFU 114354109 114357052
PXY 105381601 105382604
PGW 126379862 126380374
CFEL 113381984 113382094 113382095
CCRN 123294859
API 100164493
DNX 107170240
AGS 114131679
RMD 113550064
ACOO 126834724
DVT 126906157
BTAB 109040424
DCI 103511570
CLEC 106672202
HHAL 106685955
NLU 111049763
HVI 124359640
PHU Phum_PHUM489260
FOC 113210867 113214822
TPAL 117650272 117651916
ZNE 110836005
CSEC 111867521
SGRE 126339020 126339036
BROR 134534165
IEL 124162942
FCD 110856173
DPX DAPPUDRAFT_299789
DMK 116919773
DPZ 124341893
PVM 113800367
PJA 122266448
PCHN 125039767
PMOO 119586202
HAME 121875227 121875315
PCLA 123757213
CQD 128697141 128697161
PTRU 123503647
ESN 126988545
MNZ 135200777
HAZT 108672063
EAF 111700268
LSM 121119093
TCF 131884743
PPOI 119089544
ISC 8051190
DSV 119461856
RSAN 119395709
RMP 119174103
VDE 111246771
VJA 111261356
TUT 107360644
DPTE 113791783 113798578
DFR 124490400 124498538 124499261
CSCU 111628029 111640538
PTEP 107443400 107443407 107444042 107444043
ABRU 129963812 129964069 129964070
UDV 129217412 129217414 129217417
SDM 118183746 118187370 118193954 118193955 118193956
LPOL 106462667
PMEO 129583335 129583377 129584270 129584271 129586187 129589768 129589791 129589810 129589832 129592188 129598566
CEL CELE_F01G4.2(ard-1)
CBR CBG_06017(Cbr-ard-1)
CRQ GCK72_014065 GCK72_014228
NAI NECAME_03624
BMY BM_BM3137(Bma-ard-1.1) BM_BM3231(Bma-ard-1.2)
LOA LOAG_02590 LOAG_02591
HRO HELRODRAFT_62336
LGI LOTGIDRAFT_130767 LOTGIDRAFT_130874
PVUL 126828734
PCAN 112572112
BGT 106056571
GAE 121367959
HRF 124136333
HRJ 124253271
CRG 105337727 105349048
CVN 111106365 111108694 111109578 111109751
CANU 128157694 128159502 128161110
OED 125655895 125656946
MYI 110451007
PMAX 117330948
MCAF 127700854
MMER 123529183
RPHI 132755698
DPOL 127869198
OBI 106870550
OSN 115209392
LAK 106166979
SMM Smp_151030
SHX MS3_00007148
OVI T265_14188
EGL EGR_00218
NVE 5516466 5516467
EPA 110234807 110234808
ATEN 116304314 116304315
AMIL 114960870
PDAM 113677917
SPIS 111326563 111327200
DGT 114530007
XEN 124447390
HMG 100210676
HSY 130654996
TAD TRIADDRAFT_22420 TRIADDRAFT_51183
AQU 100642054
SSL SS1G_12339
BFU BCIN_05g06820
MBE MBM_06971
PSCO LY89DRAFT_690741
GLZ GLAREA_10926
HIR HETIRDRAFT_410926
PSQ PUNSTDRAFT_54939
GTR GLOTRDRAFT_128483
ABP AGABI1DRAFT119037(AGABI1DRAFT_119037)
MRR Moror_1115 Moror_1116
WSE WALSEDRAFT_66965 WALSEDRAFT_66966
MBR MONBRDRAFT_35161
SRE PTSG_09481
TET TTHERM_00085280 TTHERM_00085290 TTHERM_00085300 TTHERM_00085310
FCY FRACYDRAFT_229426
TPS THAPS_263178(HCD1)
PIF PITG_05542
PSOJ PHYSODRAFT_284787
SPAR SPRG_04958
MLQ ASQ50_13255
AMAA amad1_20275
AMAD I636_19425
AMAI I635_20265
AMAG I533_19160
ALN AS19_06730
ADI B5T_03344
AXE P40_15700
APAC S7S_05705
GPB HDN1F_11030(hadH2)
VIG BKP57_16440
VPN A21D_02478(fabG_5)
SALE EPH95_16455
SLP Slip_1987
PBRO HOP40_05980
 ยป show all
Reference
1  [PMID:4150713]
  Authors
Conrad RS, Massey LK, Sokatch JR.
  Title
D- and L-isoleucine metabolism and regulation of their pathways in Pseudomonas putida.
  Journal
J Bacteriol 118:103-11 (1974)
DOI:10.1128/JB.118.1.103-111.1974
Other DBs
ExplorEnz - The Enzyme Database:  1.1.1.178
IUBMB Enzyme Nomenclature:  1.1.1.178
ExPASy - ENZYME nomenclature database:  1.1.1.178
BRENDA, the Enzyme Database:  1.1.1.178
CAS:  52227-66-4

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