KEGG     ENZYME: 1.1.1.331
Entry
EC 1.1.1.331                Enzyme                                 
Name
secoisolariciresinol dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(-)-secoisolariciresinol:NAD+ oxidoreductase
Reaction(IUBMB)
(-)-secoisolariciresinol + 2 NAD+ = (-)-matairesinol + 2 NADH + 2 H+ [RN:R10129]
Reaction(KEGG)
R10129
Substrate
(-)-secoisolariciresinol [CPD:C18167];
NAD+ [CPD:C00003]
Product
(-)-matairesinol [CPD:C10682];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Isolated from the plants Forsythia intermedia [1] and Podophyllum peltatum [1-3]. An intermediate lactol is detected in vitro.
History
EC 1.1.1.331 created 2012
Pathway
ec00999   Biosynthesis of various plant secondary metabolites
ec01100   Metabolic pathways
ec01110   Biosynthesis of secondary metabolites
Orthology
K19650   secoisolariciresinol dehydrogenase
Reference
1  [PMID:11278426]
  Authors
Xia ZQ, Costa MA, Pelissier HC, Davin LB, Lewis NG
  Title
Secoisolariciresinol dehydrogenase purification, cloning, and functional expression. Implications for human health protection.
  Journal
J Biol Chem 276:12614-23 (2001)
DOI:10.1074/jbc.M008622200
  Sequence
[ag:AAK38664]
Reference
2  [PMID:15653677]
  Authors
Youn B, Moinuddin SG, Davin LB, Lewis NG, Kang C
  Title
Crystal structures of apo-form and binary/ternary complexes of Podophyllum secoisolariciresinol dehydrogenase, an enzyme involved in formation of health-protecting and plant defense lignans.
  Journal
J Biol Chem 280:12917-26 (2005)
DOI:10.1074/jbc.M413266200
  Sequence
[ag:AAK38664]
Reference
3  [PMID:16493463]
  Authors
Moinuddin SG, Youn B, Bedgar DL, Costa MA, Helms GL, Kang C, Davin LB, Lewis NG
  Title
Secoisolariciresinol dehydrogenase: mode of catalysis and stereospecificity of hydride transfer in Podophyllum peltatum.
  Journal
Org Biomol Chem 4:808-16 (2006)
DOI:10.1039/b516563f
  Sequence
[ag:AAK38664]
Other DBs
ExplorEnz - The Enzyme Database:  1.1.1.331
IUBMB Enzyme Nomenclature:  1.1.1.331
ExPASy - ENZYME nomenclature database:  1.1.1.331
BRENDA, the Enzyme Database:  1.1.1.331

  All links   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (2)   
Protein sequence (35)   
   UniProt (32)   
   SWISS-PROT (3)   
Protein domain (4)   
   InterPro (4)   
All databases (56)   

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