| Entry |
|
| Name |
homoisocitrate dehydrogenase;
2-hydroxy-3-carboxyadipate dehydrogenase;
3-carboxy-2-hydroxyadipate dehydrogenase;
homoisocitric dehydrogenase;
(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating);
3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating);
HICDH
|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
|
| Sysname |
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)
|
| Reaction(IUBMB) |
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+ [RN: R01934]
|
| Reaction(KEGG) |
|
| Substrate |
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate [CPD: C05662];
NAD+ [CPD: C00003]
|
| Product |
|
| Comment |
Forms part of the lysine biosynthesis pathway in fungi [3].
|
| History |
EC 1.1.1.87 created 1972 (EC 1.1.1.155 created 1976, incorporated 2004)
|
| Pathway |
| ec01110 |
Biosynthesis of secondary metabolites |
| ec01120 |
Microbial metabolism in diverse environments |
|
| Orthology |
| K05824 |
homoisocitrate dehydrogenase |
| K10978 |
methanogen homoisocitrate dehydrogenase |
|
| Genes |
| NCS: |
NCAS_0B06250(NCAS0B06250) |
| NDI: |
NDAI_0B03550(NDAI0B03550) |
| TPF: |
TPHA_0C03410(TPHA0C03410) |
| TBL: |
TBLA_0B05940(TBLA0B05940) |
| TDL: |
TDEL_0G02180(TDEL0G02180) |
| KAF: |
KAFR_0J01360(KAFR0J01360) |
| KNG: |
KNAG_0A05420(KNAG0A05420) |
| PGU: |
PGUG_03875 PGUG_03876 |
| CAL: |
CAALFM_CR01400WA(LYS12) |
| BBRX: |
BRETT_002820(LYS12) |
| NTE: |
NEUTE1DRAFT119171(NEUTE1DRAFT_119171) |
| PBEL: |
QC761_106340(LYS12) |
| PPSD: |
QC762_106340(LYS12) |
| PPSP: |
QC763_106340(LYS12) |
| PPSA: |
QC764_106340(LYS12) |
| FPOA: |
FPOAC1_001498(LYS12) |
| PTKZ: |
JDV02_009506(LYS12) |
| ALUC: |
AKAW2_60443S(LYS12) |
| CCAC: |
CcaHIS019_0111110(LYS12) |
| ABP: |
AGABI1DRAFT113649(AGABI1DRAFT_113649) |
| ABV: |
AGABI2DRAFT191701(AGABI2DRAFT_191701) |
| SCM: |
SCHCO_02623734(SCHCODRAFT_02623734) |
| MEHF: |
MmiHf6_03260(hicd_1) |
| MEES: |
MmiEs2_06130(hicd_2) |
| MEUZ: |
KRP56_01655 KRP56_05915 |
ยป show all
|
| Reference |
|
| Authors |
Strassman M, Ceci LN.
|
| Title |
Enzymatic formation of alpha-ketoadipic acid from homoisocitric acid.
|
| Journal |
J Biol Chem 240:4357-61 (1965)
|
| Reference |
|
| Authors |
Rowley B, Tucci AF
|
| Title |
Homoisocitric dehydrogenase from yeast.
|
| Journal |
|
| Sequence |
|
| Reference |
|
| Authors |
Zabriskie TM, Jackson MD.
|
| Title |
Lysine biosynthesis and metabolism in fungi.
|
| Journal |
|
| Other DBs |
| ExplorEnz - The Enzyme Database: |
1.1.1.87 |
| ExPASy - ENZYME nomenclature database: |
1.1.1.87 |
|
