Entry |
|
Name |
hydroxymethylglutaryl-CoA reductase;
beta-hydroxy-beta-methylglutaryl coenzyme A reductase (ambiguous);
beta-hydroxy-beta-methylglutaryl CoA-reductase (ambiguous);
3-hydroxy-3-methylglutaryl coenzyme A reductase (ambiguous);
hydroxymethylglutaryl coenzyme A reductase (ambiguous)
|
Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
|
Sysname |
(R)-mevalonate:NAD+ oxidoreductase (CoA-acylating)
|
Reaction(IUBMB) |
(R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+ [RN: R02081]
|
Reaction(KEGG) |
|
Substrate |
|
Product |
|
History |
EC 1.1.1.88 created 1972, modified 2002
|
Pathway |
ec00900 |
Terpenoid backbone biosynthesis |
ec01110 |
Biosynthesis of secondary metabolites |
|
Orthology |
K00054 |
hydroxymethylglutaryl-CoA reductase |
|
Genes |
PTAE: |
NCTC10697_02276(mvaA) |
LFA: |
LFA_1198(hmgA) LFA_2262(mvaA) |
LLG: |
44548918_02234(mvaA) |
LJR: |
NCTC11533_02313(mvaA) |
LCJ: |
NCTC11976_02826(mvaA) |
LWA: |
SAMEA4504053_2305(mvaA_1) SAMEA4504053_2440(mvaA_2) |
LSS: |
NCTC12082_01446(mvaA) |
LADL: |
NCTC12735_01483(mvaA) |
ALCA: |
ASALC70_02192(mvaA_2) |
AXX: |
ERS451415_03082(mvaA) |
MAQU: |
Maq22A_c21635(hmg1) |
SPSE: |
SULPSESMR1_00707(mvaA) |
LALG: |
LentiSH36_02213(mvaA) |
PPRU: |
FDP22_15890 FDP22_19260 |
MSD: |
MYSTI_05245 MYSTI_05505 |
MFB: |
MFUL124B02_01470 MFUL124B02_11615 MFUL124B02_14135 MFUL124B02_28770 MFUL124B02_30010 |
MYX: |
QEG98_27240 QEG98_34385 |
AGE: |
AA314_01868 AA314_03811 |
AVM: |
JQX13_22175 JQX13_33160 |
MBD: |
MEBOL_004335 MEBOL_005713 |
PAUU: |
E8A73_032560 E8A73_039820 |
SAMY: |
DB32_000804 DB32_006294 |
BSED: |
DN745_02575 DN745_02590 |
VIL: |
CFK37_04990 CFK37_10080 |
VNE: |
CFK40_00660 CFK40_05840 |
LAO: |
AOX59_08350 AOX59_12535 |
LEX: |
Len3610_12185 Len3610_16815 |
SUX: |
SAEMRSA15_24480(mvaA) |
SUF: |
SARLGA251_23200(mvaA) |
SAUT: |
SAI1T1_2018940(mvaA) |
SAUJ: |
SAI2T2_1018950(mvaA) |
SAUK: |
SAI3T3_1018940(mvaA) |
SAUQ: |
SAI4T8_1018950(mvaA) |
SPIC: |
SAMEA4384060_0646(mvaA) |
SSH: |
NCTC13712_02499(mvaA) |
SSIM: |
SAMEA4384339_2347(mvaA) |
GMO: |
NCTC11323_00064(mvaA) |
GHA: |
NCTC10459_01687(mvaA) |
STG: |
MGAS15252_0711(mvaS1) |
STX: |
MGAS1882_0707(mvaS1) |
SNV: |
SPNINV200_15480(mvaA) |
SPNG: |
HMPREF1038_01706(mvaA) |
SPNE: |
SPN034156_06050(mvaA) |
SPNU: |
SPN034183_15150(mvaA) |
SPNM: |
SPN994038_15040(mvaA) |
SPNO: |
SPN994039_15050(mvaA) |
SMC: |
SmuNN2025_1085(mvaA) |
SGG: |
SGGBAA2069_c12510(mvaA) |
STRG: |
SRT_11520(mvaA) SRT_11530(mvaA) |
SVB: |
NCTC12167_00608(mvaA) |
SMEN: |
SAMEA4412692_1229(mvaA) |
SFER: |
NCTC12278_01037(mvaA) |
SCAI: |
NCTC12191_01809(mvaA) |
SPSU: |
NCTC13786_02079(mvaA) |
SPOC: |
NCTC10925_01058(mvaA) |
SAUP: |
NCTC3168_01009(mvaA) |
SURN: |
NCTC13766_00981(mvaA) |
SVF: |
NCTC3166_01739(mvaA) |
SMIE: |
NCTC11169_00165(mvaA) |
LPW: |
LpgJCM5343_13710(mvaA) |
LOR: |
AYI71_00910 AYI71_08400 |
ECEC: |
NCTC12421_01572(atoB) |
AHK: |
NCTC10172_00895(mvaA) |
RPSK: |
JWS13_01220 JWS13_15810 |
BAFH: |
BafHLJ01_0755(mvaA) |
FOK: |
KK2020170_04050(mvaA) |
PHG: |
KCTC32516_01348(mvaA) |
AALG: |
AREALGSMS7_00744(mvaA) |
KOS: |
KORDIASMS9_00482(mvaA) |
KAN: |
IMCC3317_23820(mvaA) |
SPON: |
HME9304_01002(mvaA) |
CGLE: |
NCTC11432_02579(mvaA) |
CTAI: |
NCTC12078_01185(mvaA) |
CTAK: |
4412677_02320(mvaA) |
CJG: |
NCTC13459_02490(mvaA) |
CANT: |
NCTC13489_02506(mvaA) |
PTAN: |
CRYO30217_02152(mvaA) |
TVO: |
TVG1221182(TVG1221182) |
BARC: |
AOA65_0748 AOA65_0762(hmgA) |
LOKI: |
Lokiarch_22660(mvaA) |
ยป show all
|
Reference |
1
|
Authors |
Fimognari, G.M. and Rodwell, V.W.
|
Title |
Substrate-competitive inhibition of bacterial mevalonate:nicotinamide-adenine dinucleotide oxidoreductase (acylating CoA).
|
Journal |
Biochemistry 4:2086-2090 (1965)
|
Other DBs |
ExplorEnz - The Enzyme Database: |
1.1.1.88 |
ExPASy - ENZYME nomenclature database: |
1.1.1.88 |
|