KEGG ENZYME: 1.3.1.78

ENZYME: 1.3.1.78

Entry

EC 1.3.1.78                 Enzyme

Name

arogenate dehydrogenase (NADP+);
arogenic dehydrogenase (ambiguous);
pretyrosine dehydrogenase (ambiguous);
TyrAAT1;
TyrAAT2;
TyrAa

Class

Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

L-arogenate:NADP+ oxidoreductase (decarboxylating)

Reaction(IUBMB)

L-arogenate + NADP+ = L-tyrosine + NADPH + CO2 [RN:R00733]

Reaction(KEGG)

R00733

Substrate

L-arogenate [CPD:C00826];
NADP+ [CPD:C00006]

Product

L-tyrosine [CPD:C00082];
NADPH [CPD:C00005];
CO2 [CPD:C00011]

Comment

Arogenate dehydrogenases may utilize NAD+ (EC 1.3.1.43), NADP+ (EC 1.3.1.78), or both (EC 1.3.1.79). NADP+-dependent enzymes usually predominate in higher plants.The enzyme from the cyanobacterium Synechocystis sp. PCC 6803 and the TyrAAT1 isoform of the plant Arabidopsis thaliana cannot use prephenate as a substrate, while the Arabidopsis isoform TyrAAT2 can use it very poorly [2,3].

History

EC 1.3.1.78 created 2005

Pathway

ec00400

Phenylalanine, tyrosine and tryptophan biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K15226

arogenate dehydrogenase (NADP+)

K15227

arogenate dehydrogenase (NADP+), plant

Genes

ATH:	AT1G15710 AT5G34930

ALY:	9304474 9328938

CRB:	111832551 17878621

CSAT:

104719228 104728176 104732493 104732495 104740255 104755882 104774398

EUS:	EUTSA_v10008067mg EUTSA_v10020287mg

BRP:	103842888 103858107

BNA:	106414620 106438203 111200313 125584331 125591290

BOE:	106311520 106335007

RSZ:	108811778 108847856 108857986

THJ:	104808204 104812465 104815295 104824345 104826560

CPAP:

110821063 110821065 110826128

CIT:	102607475 102611864 102624096

CIC:	CICLE_v10007630mg CICLE_v10025846mg CICLE_v10032371mg

PVY:	116111666 116120968

MINC:

123227930

TCC:	18588852 18588854 18589809 18595336

GRA:	105766784 105799414

GHI:	107889341 107891395 107901339 107906447 107962573

GAB:	108450113 108453256 108454509

HSYR:

120131840 120133375 120144277 120156574 120156735 120161694

DZI:	111274419 111284814 111285339

EGR:	104421031 104424190 104438618 108955710

GMX:	100787362(PDH1) 100801552(ADH1) 100803931(TYRA-A) 100809027(ADH3) 100810896(PDH2)

GSJ:	114380866 114381698 114383862 114384263 114394141 114397647 114411741

PVU:	PHAVU_001G247200g PHAVU_003G178200g

VRA:	106756143 106765463

VAR:	108323774 108329078

VUN:	114179044 114179214

VUM:	124823326 124837147 124837148

CCAJ:

109808128 109814142 109816588

APRC:

113846444 113847869 113850503

MTR:	11415867 11423073 11445490

TPRA:

123881895 123894840 123924091

CAM:	101494521 101505291 101512316 101513967

PSAT:

127073474 127084028 127084035 127136095

VVO:	131621044 131631169 131633030 131638099 131656152 131661980

LJA:	Lj4g3v1936580.1(Lj4g3v1936580.1) Lj6g3v0452120.1(Lj6g3v0452120.1)

ADU:	107469958 107494416 107496964

AIP:	107604805 107609247 107622828 107637161

AHF:	112696929 112702323 112707696 112715311 112742203 112744219 112754794 112765553 112783081

LANG:

109355921 109362216

PCIN:

129302405 129311272

QSA:	O6P43_006455 O6P43_009124 O6P43_020140 O6P43_027905

FVE:	101305676 101311619

RCN:	112183586 112186297 112188560

PPER:

18770037 18778408 18783081

PMUM:

103328066 103342969

PAVI:

110756235 110769140

PDUL:

117620660 117623592 117634118

MDM:

108173469

MSYL:

126611608

PXB:	103928925 103928944 103930850 103953879

ZJU:	107407580 107413940

MNT:	21395503 21407648

CSAV:

115703598 115707881 115725067

CSV:

101214147

CMO:

103496957

BHJ:

120080457

MCHA:

111013055

CMAX:

111465461 111493711

CMOS:

111444329 111450314

CPEP:

111785711 111798049 111805854

RCU:	107261139 8259490 8263848

JCU:	105634814 105645529

HBR:	110648210 110650063 110671430

MESC:

110600150 110613841 110619090 110625567

POP:	18094861 18099902 7472451

PEU:	105111427 105113282 105122672 105139926

PALZ:

118032618 118040895 118055900

JRE:	108991826 108995634

CILL:

122292378 122305203

CAVE:

132165126 132166651 132187311 132187312

QSU:	112008752 112027884 112027906

QLO:

115954823

TWL:	120007714 120011471 120013578

VVI:	100241212 100248082 100251480 100263817 104877397

VRI:	117921766 117922150 117922154 117927604

SLY:	101259263 101259361 101264432

SPEN:

107023185 107026479 107030600

SOT:	102579802 102587993 102605098

SSTN:

125870837 125872559 125875929

SDUL:

129881510 129891440 129901664

CANN:

107842110 107856230 107873327 107876377

LBB:	132603107 132611240 132623583 132630626

NTA:	107764315 107779931 107782363 107798411 107805642 107813162

NSY:	104211780 104215149 104244162

NTO:	104084486 104084839 104116640

NAU:	109206432 109217460 109241120

INI:	109147944 109154996 109164138 109176464 109178775

ITR:	116000391 116002100 116013721 116019510 116032443

SIND:

105160837 105162242 105166429

OEU:	111368391 111368530 111389512 111390713 111402269 111407915

EGT:	105960662 105977769

SSPL:

121744294 121749586 121752428 121796173 121799916 121805634

SMIL:

130988215 130989248

SHIS:

125190668 125192354 125220194

APAN:

127239711 127256231 127266368

HAN:	110904815 110928670

ECAD:

122599633 122602638

LSV:	111877801 111879836 111905077

CCAV:

112500022 112500788 112520080 112520254

DCR:

108215982

CSIN:

114293661 114309941

RVL:	131299622 131301575

AEW:	130790975 130792365 130796152

BVG:	104901924 104901927

SOE:	110789416 110789423

CQI:	110708031 110725557

ATRI:

130815986 130815987 130828225

MOF:	131146825 131157569 131158178

NNU:	104588604 104592542 104602503 104610673 104611605 104613112

MING:

122057600 122058481 122059402 122066903 122081462

TSS:	122638751 122643325 122649727 122651020 122652194 122660366

PSOM:

113280966 113289961 113314277 113317376 113320481 113323165 113354339

OSA:	107277437 4341232 4342026

DOSA:

Os06t0542200-01(Os06g0542200) Os06t0708832-00(Os06g0708832) Os06t0709000-01(Os06g0709000)

OBR:	102706391 102716604 107304376

OGL:	127775676 127776101 127776104

BDI:	100828973 100829970 100833753

ATS:	109757600 109758435 109758438

TDC:	119329742 119332287 119333642 119338030 119341594 119341880

TAES:

123147895 123148531 123148532 123156075 123160230 123161907 123163666 123166534 123169064

TUA:	125507581 125520473 125524298 125524361

LPER:

127312659 127312663 127313968 127331996

LRD:	124647459 124657598 124683345 124684069

SBI:	8064968 8064969 8072682

ZMA:	100276497 100281038 100281078 100284089

SITA:

101769617 101776886 106804311

SVS:	117851285 117851355 117852217

PVIR:

120668758 120668760 120670683 120703645 120704437 120704440

PHAI:

112888356 112888411 112889471

PDA:	103709458 103710118 103715890 103721502

EGU:	105033050 105057363

MUS:	103985416 103986814 103990066 103990067

ZOF:	121974571 122033170

DCT:	110108381 110110004

PEQ:	110018080 110036088 110038143

AOF:	109835324 109835734 109843924

MSIN:

131222412 131223695 131241022 131246916 131253469

NCOL:

116249701 116267039

ATR:	18423492 18442140 18447759

SMO:	SELMODRAFT_147857 SELMODRAFT_34770

PPP:	112280496 112281008 112285748 112289182

CRE:	CHLRE_06g278350v5

VCN:	VOLCADRAFT_78949(agd1)

MNG:

MNEG_1533

CSL:	COCSUDRAFT_14797

CVR:	CHLNCDRAFT_18936

APRO:

F751_6083

OLU:	OSTLU_119548(ardH)

OTA:	OT_ostta02g01980

BPG:	Bathy14g02110

MIS:	MICPUN_102217

MPP:	MICPUCDRAFT_4596(JGI:MicpuC2_4596)

CME:	CYME_CMS326C

GSL:	Gasu_01630

CCP:	CHC_T00003598001

FCY:	FRACYDRAFT_191710(tyrC)

AAF:	AURANDRAFT_3833

SYN:	slr2081(tyrA)

SYZ:	MYO_114060(tyrA)

SYY:	SYNGTS_1394(tyrA)

SYT:	SYNGTI_1394(tyrA)

SYS:	SYNPCCN_1393(tyrA)

SYQ:	SYNPCCP_1393(tyrA)

SYJ:	D082_12010(tyrA)

SYO:	C7I86_07220

SYC:	syc0868_c(tyrA)

SYU:	M744_13510

SYF:	Synpcc7942_0660

SYD:	Syncc9605_0385

SYE:	Syncc9902_1945

SYG:	sync_0447(tyrA)

SYR:	SynRCC307_2107(tyrA)

SYX:	SynWH7803_0443(tyrA)

CYA:	CYA_2300(tyrA)

CYB:	CYB_0624(tyrA)

SYNE:

Syn6312_1438

SYNP:

Syn7502_00098

SYNK:

KR100_03435

SYNR:

KR49_10995

SYND:

KR52_00505

SYH:	Syncc8109_0393

SYNW:

SynWH8103_02365(tyrA)

SYNC:

CB0101_10610

SYNY:

BM449_08715

DSL:	Dacsa_0703

SYW:

SYNW2058

CGC:	Cyagr_1800

CYI:	CBM981_1843

PMA:	Pro_1719(tyrA)

PMM:

PMM1565

PMT:

PMT_1724

PMN:	PMN2A_1136

PMI:	PMT9312_1657

PMB:	A9601_17721(tyrA)

PMC:	P9515_17521(tyrA)

PMF:	P9303_22941(tyrA)

PMG:	P9301_17561(tyrA)

PMH:	P9215_18371(tyrA)

PMJ:	P9211_16841(tyrA)

PME:	NATL1_20101(tyrA)

PRC:

EW14_1923

PRM:

EW15_2083

WNA:	KA717_32825

CMP:	Cha6605_5283

CYN:	Cyan7425_3574

CEP:	Cri9333_1775

TVN:	NIES2134_101300(tyrA)

SLW:	BRW62_03525

AMR:	AM1_2942(tyrA)

ACAM:

HRE53_11755

TEL:	tll2435(tyrA)

THN:	NK55_00825(tyrA)

THEC:

FFX45_12545

TSZ:	OOK60_00410

LEN:	LEP3755_15060

LET:	O77CONTIG1_00666(tyrA)

LBO:

LBWT_6830

KOV:	K9N68_19390

LSC:	KIK02_13145

LSK:	J5X98_09300

HHG:	XM38_009440(tyrA)

PSEU:

Pse7367_1830

PSER:

ABRG53_1798(tyrA)

PGX:	OA858_11070

THEU:

HPC62_12710

TOG:	HNI00_15685

TSIN:

OXH18_16115

GLP:	Glo7428_1710

CHON:

NIES4102_24130

GDU:	P0S91_15320

GEN:	GM3709_2701

GEE:	GM3708_1698

CAN:	Cyan10605_0182

CSN:	Cyast_1229

CYL:	AA637_05210(tyrAa)

SYP:	SYNPCC7002_A0677(tyrA)

SYV:	AWQ23_03540

SYL:	AWQ21_04085

LEP:	Lepto7376_0061

SYNN:

NIES970_00390(tyrA)

MAR:

MAE_55280

MPK:

VL20_422

MIQ:	B5D77_25225

MVZ:	myaer102_27660

HAO:	PCC7418_1433

ENN:	FRE64_00645

CYT:	cce_4463(tyrA)

CWA:	CwatDRAFT_4419

CYP:	PCC8801_0596

CYH:	Cyan8802_0611

CYC:	PCC7424_2019

CYJ:	Cyan7822_3353

TER:

Tery_2701

ARP:	NIES39_N00690(tyrA)

PAGH:

NIES204_34900(tyrA)

PPSU:

NO713_04760(tyrA)

PRUN:

PCC7821_00377(tyrA)

OXY:	HCG48_09750

MVAG:

D0A34_12960

LFS:	HFV01_14730

OAC:	Oscil6304_3355

ONI:	Osc7112_4172

MPRO:

BJP34_16235

MIC:	Mic7113_2359

GEI:	GEI7407_0094

GVI:	glr0406(tyrA)

GLJ:	GKIL_4393(tyrAa)

GML:	ISF26_20060

ANA:

all1141

NPU:	Npun_R0978

NOS:	Nos7107_2223

NOP:	Nos7524_2310

NON:	NOS3756_17370

NFL:	COO91_07496

NOE:	CLI64_15270

NSH:

GXM_06625

NED:	HUN01_07750

NPZ:	ACX27_23050

AVA:

Ava_4397

NAZ:

Aazo_3900

ANB:	ANA_C20257

ACY:	Anacy_4791

AWA:	AA650_16670

ANN:	EH233_04250

CSG:	Cylst_3355

RSIN:

B6N60_01578

HBQ:	QI031_06980

CALO:

Cal7507_1077

CALT:

Cal6303_4074

CALH:

IJ00_23290

CALN:

NIES2098_19220

CALS:

NIES3974_37710

RIV:	Riv7116_2767

FIS:	FIS3754_49490

NSP:	BMF81_02506

NSPH:

BDGGKGIB_01694(tyrC)

DOU:	BMF77_02823(tyrA_2)

DFS:	HGD76_22110

DHT:	NG743_08335

CCUR:

IAR63_13475

CRK:	L3I90_12310

AFLO:

HEQ12_17930

STOQ:

K2F26_05700

AEE:	IM676_01710

RCS:	NIES932_09070

TOQ:	HCG51_07315

ALAX:

NIES50_35520

NCN:	BZZ01_11940

CTHE:

Chro_0609

PLP:	Ple7327_0729

SCS:	Sta7437_4289

STAN:

STA3757_37290

GLT:	GlitD10_1195(tyrAa)

GCY:	LQF76_09635

CEO:	ETSB_0416(tyrA)

CER:	RGRSB_0377(tyrA)

CEEC:

P3F56_01955

MBF:	BHV42_04645

» show all

Reference

1 [PMID:24272471]

Authors

Gaines CG, Byng GS, Whitaker RJ, Jensen RA

Title

L-tyrosine regulation and biosynthesis via arogenate dehydrogenase in suspension-cultured cells of Nicotiana silvestris Speg. et Comes.

Journal

Planta 156:233-40 (1982)
DOI:10.1007/BF00393730

Reference

2 [PMID:12354106]

Authors

Rippert P, Matringe M

Title

Purification and kinetic analysis of the two recombinant arogenate dehydrogenase isoforms of Arabidopsis thaliana.

Journal

Eur J Biochem 269:4753-61 (2002)
DOI:10.1046/j.1432-1033.2002.03172.x

Sequence

[ath:AT5G34930 AT1G15710]

Reference

3 [PMID:15171683]

Authors

Bonner CA, Jensen RA, Gander JE, Keyhani NO

Title

A core catalytic domain of the TyrA protein family: arogenate dehydrogenase from Synechocystis.

Journal

Biochem J 382:279-91 (2004)
DOI:10.1042/BJ20031809

Sequence

[syn:slr2081]

Other DBs

ExplorEnz - The Enzyme Database:

1.3.1.78

IUBMB Enzyme Nomenclature:

1.3.1.78

ExPASy - ENZYME nomenclature database:

1.3.1.78

BRENDA, the Enzyme Database:

1.3.1.78

CAS:	64295-75-6

DBGET integrated database retrieval system