KEGG ENZYME: 1.5.1.10

ENZYME: 1.5.1.10

Entry

EC 1.5.1.10                 Enzyme

Name

saccharopine dehydrogenase (NADP+, L-glutamate-forming);
saccharopine (nicotinamide adenine dinucleotide phosphate, glutamate-forming) dehydrogenase;
aminoadipic semialdehyde-glutamic reductase;
aminoadipate semialdehyde-glutamate reductase;
aminoadipic semialdehyde-glutamate reductase;
epsilon-N-(L-glutaryl-2)-L-lysine:NAD+(P) oxidoreductase (L-2-aminoadipate-semialdehyde forming);
saccharopine reductase;
6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)

Class

Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)

Reaction(IUBMB)

N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-glutamate + (S)-2-amino-6-oxohexanoate + NADPH + H+ [RN:R02315]

Reaction(KEGG)

R02315

Substrate

N6-(L-1,3-dicarboxypropyl)-L-lysine [CPD:C00449];
NADP+ [CPD:C00006];
H2O [CPD:C00001]

Product

L-glutamate [CPD:C00025];
(S)-2-amino-6-oxohexanoate [CPD:C04076];
NADPH [CPD:C00005];
H+ [CPD:C00080]

History

EC 1.5.1.10 created 1972, modified 2011

Pathway

ec00300

Lysine biosynthesis

ec00310

Lysine degradation

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K00293

saccharopine dehydrogenase (NADP+, L-glutamate forming)

K24034

spermidine synthase / saccharopine dehydrogenase (NADP+, L-glutamate-forming)

Genes

SHON:

118994002

AJM:

119046515

NVE:

116616792

SCE:	YNR050C(LYS9)

SEUB:

DI49_4783

SPAO:

SPAR_N03520

AGO:	AGOS_ABR116C

ERC:

Ecym_7008

KLA:	KLLA0_C18744g

KMX:	KLMA_40016(LYS9)

LTH:	KLTH0A07590g

VPO:	Kpol_1028p12

ZRO:	ZYRO0D17578g

CGR:	CAGL0C03443g

NCS:	NCAS_0A05670(NCAS0A05670)

NDI:	NDAI_0K02690(NDAI0K02690)

TPF:	TPHA_0M02120(TPHA0M02120)

TBL:	TBLA_0F00190(TBLA0F00190)

TGB:	HG536_0A09500

TDL:	TDEL_0A07910(TDEL0A07910)

KAF:	KAFR_0C04810(KAFR0C04810)

KNG:	KNAG_0D00180(KNAG0D00180)

ZMK:	HG535_0F00210

PPA:	PAS_chr3_0528

DHA:	DEHA2F17424g

PIC:	PICST_70210(LYS9)

PGU:	PGUG_04239

SPAA:

SPAPADRAFT_62366

LEL:	PVL30_003814(LYS9)

CAL:	CAALFM_C306590WA(LYS9)

CTP:	CTRG_05710

COT:	CORT_0C00740

CDU:	CD36_86570

CTEN:

CANTEDRAFT_117343

YLI:	YALI0D22891g

CLU:	CLUG_04206

CLUS:

A9F13_04g03179

CAUR:

CJI96_0004931

PKZ:	C5L36_0E03900

BNN:	FOA43_001036(LYS9)

BBRX:

BRETT_003666(LYS9)

OPA:	HPODL_04616

SLUD:

SCDLUD_003780

NCR:

NCU03748

NTE:	NEUTE1DRAFT58317(NEUTE1DRAFT_58317)

SMP:	SMAC_02595

PAN:	PODANSg8147

PBEL:

QC761_203550(LYS9)

PPSD:

QC762_203550(LYS9)

PPSP:

QC763_203550(LYS9)

PPSA:

QC764_203550(LYS9)

TTT:	THITE_2050253 THITE_2107047

MTM:	MYCTH_2300877

CTHR:

CTHT_0065790

MGR:

MGG_17041

PPEI:

PpBr36_10814

PGRI:

PgNI_00200

TMN:	UCRPA7_3100

SSCK:

SPSK_03190

FGR:	FGSG_00346

FPU:	FPSE_00004 FPSE_09212

FPOA:

FPOAC1_000362(LYS3) FPOAC1_003319

FVN:	FVRRES_00498

FVR:	FVEG_00801

FOX:	FOXG_00713

NHE:	NECHADRAFT_101578 NECHADRAFT_92326

FFC:	NCS54_00466900 NCS54_01134500

FKR:	NCS57_00474100 NCS57_01125000

FMU:	J7337_001193(LYS3)

TRE:	TRIREDRAFT_123631

TRR:	M419DRAFT_88293

MAW:

MAC_01390

MAJ:

MAA_08309

PCHM:

VFPPC_16295

CMT:

CCM_00396

AMUS:

LMH87_000649

PLJ:	VFPFJ_07841

PTKZ:

JDV02_005266(LYS9)

VAL:	VDBG_04207

VDA:	VDAG_01433

CFJ:	CFIO01_01988 CFIO01_06768

CLUP:

CLUP02_08240

CHIG:

CH63R_03270 CH63R_08861

SAPO:

SAPIO_CDS0514

ELA:	UCREL1_7945 UCREL1_8042

PFY:	PFICI_12081

SSL:	SS1G_13213

BFU:	BCIN_03g09280(Bclys9)

MBE:

MBM_03741

PSCO:

LY89DRAFT_705797

GLZ:	GLAREA_00865 GLAREA_05240

ANI:	ANIA_05601

AFM:	AFUA_4G11340

ACT:	ACLA_003400 ACLA_050430

NFI:	NFIA_105250

AOR:	AO090001000233 AO090003001086

ANG:	An01g13590 An04g05260

AFV:	AFLA_000585 AFLA_008579

ALUC:

AKAW2_10277A AKAW2_51500S(LYS3)

ACHE:

ACHE_10568A(LYS3)

APUU:

APUU_40960S(LYS3)

PCS:	N7525_000842 N7525_005645

PDP:	PDIP_34140

POU:	POX_a01490

TMF:	EYB26_005353

TRG:	TRUGW13939_02837

CIM:	CIMG_01555

CPW:	CPC735_049050

URE:	UREG_05275

PBL:	PAAG_02693

PBN:	PADG_01718

ABE:

ARB_02329

TVE:

TRV_04693

AJE:	HCAG_01575

BGH:	BDBG_07199

PNO:	SNOG_09324

PTE:

PTT_10655

BZE:	COCCADRAFT_8652

BSC:	COCSADRAFT_188437

BOR:	COCMIDRAFT_39282

AALT:

CC77DRAFT_143741

ARAB:

EKO05_0003172

ZTR:	MYCGRDRAFT_110462(LYS9)

PFJ:	MYCFIDRAFT_49608 MYCFIDRAFT_54301

FFU:	CLAFUR5_07080

CBET:

CB0940_06498

BCOM:

BAUCODRAFT_33041

NPA:	UCRNP2_5529

TML:	GSTUM_00000988001

SPO:	SPBC3B8.03

SOM:	SOMG_00104(lys9)

CNE:

CNG01150

CNB:

CNBG3640

CNG:	CNAG_03476

CGI:	CGB_G5220C

CDEU:

CNBG_2136

TMS:	TREMEDRAFT_74272

TASA:

A1Q1_06672

CCAC:

CcaHIS019_0502360(LYS9)

TVS:	TRAVEDRAFT_53623

DSQ:	DICSQDRAFT_85486

PCO:	PHACADRAFT_187523 PHACADRAFT_262714

SHS:	STEHIDRAFT_129850 STEHIDRAFT_76391

HIR:	HETIRDRAFT_471805

PSQ:	PUNSTDRAFT_145068

ADL:	AURDEDRAFT_115750

FME:	FOMMEDRAFT_112965

GTR:	GLOTRDRAFT_139895

RSX:	RhiXN_07834

LBC:	LACBIDRAFT_177008

CCI:	CC1G_05582

ABP:	AGABI1DRAFT64147(AGABI1DRAFT_64147)

ABV:	AGABI2DRAFT184364(AGABI2DRAFT_184364)

PCUB:

JR316_0012084

MRR:	Moror_16977

E1B28_013447

SCM:	SCHCO_02542524(SCHCODRAFT_02542524) SCHCO_02628453(SCHCODRAFT_02628453)

CPUT:

CONPUDRAFT_168017 CONPUDRAFT_84267

SLA:	SERLADRAFT_362472

WSE:	WALSEDRAFT_31404

WIC:	J056_002184

UMA:	UMAG_05818

PFP:	PFL1_02581

SGRA:

EX895_003211

MGL:

MGL_1529

MRT:

MRET_3829

MSYM:

MSY001_2438

PGR:	PGTG_06954

PTRC:

PtA15_5A90

PSTR:

Pst134EA_009050

MLR:	MELLADRAFT_73077 MELLADRAFT_91581

MBR:	MONBRDRAFT_34020

DDI:	DDB_G0285267(sdh)

PTM:	GSPATT00022932001

KKO:

Kkor_1620

KPD:	CW740_04755

MTT:	Ftrac_3732

» show all

Reference

1 [PMID:4380448]

Authors

Jones EE, Broquist HP.

Title

Saccharopine, an intermediate of the aminoadipic acid pathway of lysine biosynthesis. 3. Aminoadipic semialdehyde-glutamate reductase.

Journal

J Biol Chem 241:3430-4 (1966)

Other DBs

ExplorEnz - The Enzyme Database:

1.5.1.10

IUBMB Enzyme Nomenclature:

1.5.1.10

ExPASy - ENZYME nomenclature database:

1.5.1.10

BRENDA, the Enzyme Database:

1.5.1.10

CAS:

9033-55-0

DBGET integrated database retrieval system