Clathrin has long been known to provide the structural basis for vesicle budding from the plasma membrane during endocytosis, but how is clathrin targeted specifically to some cellular membranes and not others? The answer seems to lie in the adaptors--protein complexes whose shape resembles the head of Mickey Mouse--which seem to be required both for clathrin-coat assembly and for sequestering specific receptors by interacting with their cytoplasmic domains. In this article, Margaret Robinson describes what is currently known about these versatile proteins.