Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies

Leukemia. 2010 Oct;24(10):1799-804. doi: 10.1038/leu.2010.167. Epub 2010 Aug 19.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Base Sequence
  • Chromosomes, Human, Pair 7 / genetics
  • DNA-Binding Proteins / genetics*
  • Enhancer of Zeste Homolog 2 Protein
  • Female
  • Heterozygote
  • Homozygote
  • Humans
  • Leukemia, Myeloid, Acute / genetics*
  • Leukemia, Myeloid, Acute / pathology
  • Loss of Heterozygosity
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Mutant Proteins / genetics*
  • Mutation, Missense / genetics*
  • Myelodysplastic Syndromes / genetics*
  • Myelodysplastic Syndromes / pathology
  • Myeloproliferative Disorders / genetics*
  • Myeloproliferative Disorders / pathology
  • Polycomb Repressive Complex 2
  • Polymorphism, Single Nucleotide / genetics
  • Sequence Deletion
  • Sequence Homology, Nucleic Acid
  • Transcription Factors / genetics*
  • Uniparental Disomy / genetics*
  • Uniparental Disomy / pathology

Substances

  • DNA-Binding Proteins
  • Mutant Proteins
  • Transcription Factors
  • EZH2 protein, human
  • Enhancer of Zeste Homolog 2 Protein
  • Polycomb Repressive Complex 2