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Hyaluronan-CD44 interaction promotes c-Src-mediated twist signaling, microRNA-10b expression, and RhoA/RhoC up-regulation, leading to Rho-kinase-associated cytoskeleton activation and breast tumor cell invasion.
Bourguignon LY, Wong G, Earle C, Krueger K, Spevak CC. Bourguignon LY, et al. Among authors: spevak cc. J Biol Chem. 2010 Nov 19;285(47):36721-35. doi: 10.1074/jbc.M110.162305. Epub 2010 Sep 15. J Biol Chem. 2010. PMID: 20843787 Free PMC article.
Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.
Galagan JE, Calvo SE, Cuomo C, Ma LJ, Wortman JR, Batzoglou S, Lee SI, Baştürkmen M, Spevak CC, Clutterbuck J, Kapitonov V, Jurka J, Scazzocchio C, Farman M, Butler J, Purcell S, Harris S, Braus GH, Draht O, Busch S, D'Enfert C, Bouchier C, Goldman GH, Bell-Pedersen D, Griffiths-Jones S, Doonan JH, Yu J, Vienken K, Pain A, Freitag M, Selker EU, Archer DB, Peñalva MA, Oakley BR, Momany M, Tanaka T, Kumagai T, Asai K, Machida M, Nierman WC, Denning DW, Caddick M, Hynes M, Paoletti M, Fischer R, Miller B, Dyer P, Sachs MS, Osmani SA, Birren BW. Galagan JE, et al. Among authors: spevak cc. Nature. 2005 Dec 22;438(7071):1105-15. doi: 10.1038/nature04341. Nature. 2005. PMID: 16372000
Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherapy resistance in breast tumor cells.
Bourguignon LY, Spevak CC, Wong G, Xia W, Gilad E. Bourguignon LY, et al. Among authors: spevak cc. J Biol Chem. 2009 Sep 25;284(39):26533-46. doi: 10.1074/jbc.M109.027466. Epub 2009 Jul 24. J Biol Chem. 2009. PMID: 19633292 Free PMC article.