Quinine Inhibits Infection of Human Cell Lines with SARS-CoV-2.
Große M, Ruetalo N, Layer M, Hu D, Businger R, Rheber S, Setz C, Rauch P, Auth J, Fröba M, Brysch E, Schindler M, Schubert U. Große M, et al. Viruses. 2021 Apr 9;13(4):647. doi: 10.3390/v13040647. Viruses. 2021. PMID: 33918670 Free PMC article.
In Calu-3, infections with high titers of SARS-CoV-2 were completely blocked by quinine, CQN, and H-CQN in concentrations above 50 M. The estimated IC(50)s were ~25 M in Calu-3, while overall, the inhibitors exhibit IC(50) values between ~3.7 to ~50 M, dependent on the cel …
In Calu-3, infections with high titers of SARS-CoV-2 were completely blocked by quinine, CQN, and H-CQN in concentrations above 50 M. The es …