Abstract
The persistence of H5N1 avian influenza viruses in many Asian countries and their ability to cause fatal infections in humans have raised serious concerns about a global flu pandemic. Here we report the isolation of an H5N1 virus from a Vietnamese girl that is resistant to the drug oseltamivir, which is an inhibitor of the viral enzyme neuraminidase and is currently used for protection against and treatment of influenza. Further investigation is necessary to determine the prevalence of oseltamivir-resistant H5N1 viruses among patients treated with this drug.
MeSH terms
- Acetamides / administration & dosage*
- Acetamides / pharmacology
- Acetamides / supply & distribution
- Acetamides / therapeutic use*
- Adolescent
- Adult
- DNA Mutational Analysis
- Drug Resistance, Viral / genetics*
- Female
- Ferrets
- Guanidines
- Hemagglutinin Glycoproteins, Influenza Virus / genetics
- Humans
- Influenza A Virus, H5N1 Subtype*
- Influenza A virus / drug effects*
- Influenza A virus / genetics
- Influenza A virus / growth & development
- Influenza A virus / isolation & purification*
- Influenza, Human / drug therapy*
- Influenza, Human / prevention & control
- Influenza, Human / transmission
- Influenza, Human / virology*
- Inhibitory Concentration 50
- Mutation / genetics
- Neuraminidase / antagonists & inhibitors
- Neuraminidase / chemistry
- Neuraminidase / genetics
- Neuraminidase / metabolism
- Oseltamivir
- Polymerase Chain Reaction
- Pyrans
- Sialic Acids
- Zanamivir
Substances
- Acetamides
- Guanidines
- Hemagglutinin Glycoproteins, Influenza Virus
- Pyrans
- Sialic Acids
- Oseltamivir
- Neuraminidase
- Zanamivir