Abstract
Influenza A and viruses encode minimalistic proton-selective ion channels known as A/M2 and BM2, respectively. The A/M2 channel is the target of the antiviral drug, amantadine. The structural and mechanistic aspects of proton conductance of the viral ion channels are described and the review makes a case for the development of more effective antivirals.
Publication types
- Research Support, N.I.H., Extramural
- Review
MeSH terms
- Amantadine / pharmacology
- Amino Acid Sequence
- Antiviral Agents / pharmacology
- Cell Membrane / metabolism
- Cytoplasm / metabolism
- Humans
- Ion Channels / chemistry
- Ion Channels / metabolism*
- Ion Channels / physiology
- Ion Transport
- Models, Biological
- Molecular Sequence Data
- Orthomyxoviridae / physiology*
- Protons*
- Viral Matrix Proteins / chemistry
- Viral Matrix Proteins / metabolism*
- Virus Replication*
Substances
- Antiviral Agents
- Ion Channels
- M2 protein, Influenza A virus
- Protons
- Viral Matrix Proteins
- Amantadine