Abstract
Avian influenza virus polymerases function poorly in mammals, restricting transmission across species and the emergence of pandemic outbreaks. Long et al. (2016) have now identified ANP32A as a crucial cellular protein that dictates species-specific polymerase activity.
Copyright © 2016 Elsevier Inc. All rights reserved.
Publication types
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
- Comment
MeSH terms
- Animals
- Avian Proteins / chemistry*
- Avian Proteins / metabolism*
- Host Specificity*
- Humans
- Influenza A virus / enzymology*
- Intracellular Signaling Peptides and Proteins / chemistry*
- Intracellular Signaling Peptides and Proteins / metabolism*
- RNA-Dependent RNA Polymerase / metabolism*
- Viral Proteins / metabolism*
Substances
- Avian Proteins
- Intracellular Signaling Peptides and Proteins
- Viral Proteins
- RNA-Dependent RNA Polymerase