Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.1 -- Acting on the CH-OH group of donors → 1.1.1 -- With NAD(+) or NADP(+) as acceptor

Synonyms: NAD⁺-dependent 15-hydroxyprostaglandin dehydrogenase (type I), PGDH, 11α,15-dihydroxy-9-oxoprost-13-enoate:NAD⁺ 15-oxidoreductase, 15-OH-PGDH, 15-hydroxyprostaglandin dehydrogenase, 15-hydroxyprostanoic dehydrogenase, NAD⁺-specific 15-hydroxyprostaglandin dehydrogenase, prostaglandin dehydrogenase, 15-hydroxyprostaglandin dehydrogenase (NAD⁺), (5Z,13E)-(15S)-11α,15-dihydroxy-9-oxoprost-13-enoate:NAD⁺ 15-oxidoreductase

Systematic Name: (5Z,13E,15S)-11α,15-dihydroxy-9-oxoprost-5,13-dienoate:NAD⁺ 15-oxidoreductase

Unification Links: BRENDA:1.1.1.141, ENZYME:1.1.1.141, IUBMB-ExplorEnz:1.1.1.141

Reaction:
prostaglandin E₂ + NAD⁺ → 15-dehydro-prostaglandin E₂ + NADH + H⁺

Unofficial Reactions:
resolvin D2 + NAD⁺ → 16-dehydro-resolvin D2 + NADH + H⁺,
prostaglandin F_2α + NAD⁺ → 15-dehydro-prostaglandin F_2α + NADH + H⁺,
resolvin D1 + NAD⁺ → 8-dehydro-resolvin D1 + NADH + H⁺,
resolvin D1 + NAD⁺ → 17-dehydro-resolvin D1 + NADH + H⁺,
prostaglandin B₁ + NAD⁺ → 15-dehydro-prostaglandin B₁ + NADH + H⁺,
prostaglandin F_1α + NAD⁺ → 15-dehydro-prostaglandin F_1α + NADH + H⁺,
resolvin D2 + NAD⁺ → 7-dehydro-resolvin D2 + NADH + H⁺,
lipoxin A4 + NAD⁺ → 15-oxolipoxin A4 + NADH + H⁺,
resolvin E1 + NAD⁺ → 18-dehydro-resolvin E1 + NADH + H⁺,
prostaglandin A₁ + NAD⁺ → 15-dehydro-prostaglandin A₁ + NADH + H⁺,
prostaglandin E₁ + NAD⁺ → 15-dehydro-prostaglandin E₁ + NADH + H⁺,
prostaglandin F_3α + NAD⁺ → 15-dehydro-prostaglandin F_3α + NADH + H⁺,
prostaglandin E₃ + NAD⁺ → 15-dehydro-prostaglandin E₃ + NADH + H⁺,
prostaglandin A₂ + NAD⁺ → 15-dehydro-prostaglandin A₂ + NADH + H⁺

Enzymes and Genes:
15-hydroxyprostaglandin dehydrogenase [NAD+]: HPGD ( Homo sapiens )

Summary:
Acts on prostaglandin E₂, prostaglandin F_2α, and , prostaglandin B₁, but not on prostaglandin D₂. cf. EC 1.1.1.196, 15-hydroxyprostaglandin-D dehydrogenase (NADP⁺) and EC 1.1.1.197, 15-hydroxyprostaglandin dehydrogenase (NADP⁺).

Citations: [Lee75, Lee75a, Braithwaite75]

---

References

Braithwaite75: Braithwaite SS, Jarabak J (1975). "Studies on a 15-hydroxyprostaglandin dehydrogenase from human placenta. Purification and partial characterization." J Biol Chem 250(6);2315-8. PMID: 1117007

Lee75: Lee SC, Pong SS, Katzen D, Wu KY, Levine L (1975). "Distribution of prostaglandin E 9-ketoreductase and types I and II 15-hydroxyprostaglandin dehydrogenase in swine kidney medulla and cortex." Biochemistry 14(1);142-5. PMID: 803247

Lee75a: Lee SC, Levine L (1975). "Prostaglandin metabolism. II. Identification of two 15-hydroxyprostaglandin dehydrogenase types." J Biol Chem 250(2);548-52. PMID: 234431

---

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
Page generated by Pathway Tools version 28.0 (software by SRI International) on Tue May 7, 2024, BIOCYC13.