Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.1 -- Acting on the CH-OH group of donors → 1.1.1 -- With NAD(+) or NADP(+) as acceptor

Synonyms: 20α-hydroxy steroid dehydrogenase, 20α-HSD, 20α-HSDH

Systematic Name: 20α-hydroxysteroid:NAD(P)⁺ 20-oxidoreductase

Unification Links: BRENDA:1.1.1.149, ENZYME:1.1.1.149, IUBMB-ExplorEnz:1.1.1.149

Reaction:
(20S)-17,20-dihydroxypregn-4-en-3-one + NAD(P)⁺ ↔ 17-α-hydroxyprogesterone + NAD(P)H + H⁺

Unofficial Reactions:
pregnanediol + NAD(P)⁺ ← pregnanolone + NAD(P)H + H⁺,
20α-dihydroprogesterone + NAD(P)⁺ ← progesterone + NAD(P)H + H⁺,
20α-dihydroprogesterone + NAD⁺ ↔ progesterone + NADH + H⁺

Enzymes and Genes:
aldo-keto reductase family 1 member C1: AKR1C1 ( Homo sapiens )

Summary:
Re-specific with respect to NAD(P)+ (cf. EC 1.1.1.62, 17β-estradiol 17-dehydrogenase).

Citations: [Shikita67, Strickler81]

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References

Shikita67: Shikita M, Inano H, Tamaoki B (1967). "Further studies on 20-alpha-hydroxysteroid dehydrogenase of rat testes." Biochemistry 6(6);1760-4. PMID: 4382486

Strickler81: Strickler RC, Tobias B, Covey DF (1981). "Human placental 17 beta-estradiol dehydrogenase and 20 alpha-hydroxysteroid dehydrogenase. Two activities at a single enzyme active site." J Biol Chem 256(1);316-21. PMID: 6935192

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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