Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.1 -- Acting on the CH-OH group of donors → 1.1.1 -- With NAD(+) or NADP(+) as acceptor

Synonyms: 2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase, 2-methyl-3-hydroxy-butyryl CoA dehydrogenase

Systematic Name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD⁺ oxidoreductase

Unification Links: BRENDA:1.1.1.178, ENZYME:1.1.1.178, IUBMB-ExplorEnz:1.1.1.178

Reaction:
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD⁺ ↔ 2-methylacetoacetyl-CoA + NADH + H⁺

Unofficial Reactions:
a short-chain (3S)-3-hydroxy-2-methylacyl-CoA + NAD⁺ → a short-chain 2-methyl-3-oxoacyl-CoA + NADH + H⁺,
a (3S)-3-hydroxy-2-methylacyl-CoA + NAD⁺ → a 2-methyl-3-oxoacyl-CoA + NADH + H⁺

Enzymes and Genes:
2-methylacetoacetyl-coenzyme A reductase ( Ascaris lumbricoides )
3-hydroxy-2-methylbutyryl-CoA dehydrogenase: fadB2x ( Pseudomonas putida )
type-2 3-hydroxyacyl-CoA dehydrogenase: HSD17B10 ( Homo sapiens )

Summary:
Also acts, more slowly, on (2S,3S)-2-hydroxy-3-methylpentanoyl-CoA.

Citations: [Conrad74]

---

References

Conrad74: Conrad RS, Massey LK, Sokatch JR (1974). "D- and L-isoleucine metabolism and regulation of their pathways in Pseudomonas putida." J Bacteriol 118(1);103-11. PMID: 4150713

---

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
Page generated by Pathway Tools version 28.0 (software by SRI International) on Sat Apr 27, 2024, BIOCYC18B.