Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.1 -- Acting on the CH-OH group of donors → 1.1.1 -- With NAD(+) or NADP(+) as acceptor

Synonyms: GDP-4-keto-6-deoxy-D-mannose reductase, GDP-4-keto-D-rhamnose reductase, guanosine diphosphate-4-keto-D-rhamnose reductase, GDP-6-deoxy-D-mannose:NAD(P)⁺ 4-oxidoreductase, GDP-6-deoxy-α-D-mannose:NAD(P)⁺ 4-oxidoreductase

Systematic Name: GDP-4-dehydro-α-D-rhamnose:NAD(P)⁺ 4-oxidoreductase

Unification Links: BRENDA:1.1.1.187, ENZYME:1.1.1.187, IUBMB-ExplorEnz:1.1.1.187

Reaction:
GDP-α-D-rhamnose + NAD(P)⁺ ← GDP-4-dehydro-α-D-rhamnose + NAD(P)H + H⁺,
GDP-6-deoxy-α-D-talose + NAD(P)⁺ ← GDP-4-dehydro-α-D-rhamnose + NAD(P)H + H⁺

Summary:
The enzyme, which operates in the opposite direction to that shown, forms a mixture of GDP-α-D-rhamnose and its C-4 epimer, GDP-6-deoxy-α-D-talose. cf. EC 1.1.1.281, GDP-4-dehydro-6-deoxy-D-mannose reductase and EC 1.1.1.135, GDP-6-deoxy-D-talose 4-dehydrogenase.

Citations: [Barber68, Winkler71]

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References

Barber68: Barber GA (1968). "The synthesis of guanosine 5'-diphosphate D-rhamnose by enzymes of a higher plant." Biochim Biophys Acta 165(1);68-75. PMID: 4386238

Winkler71: Winkler NW, Markovitz A (1971). "Guanosine diphosphate-4-keto-D-rhamnose reductase. A non-stereoselective enzyme." J Biol Chem 246(19);5868-76. PMID: 4398966

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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