Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.1 -- Acting on the CH-OH group of donors → 1.1.1 -- With NAD(+) or NADP(+) as acceptor

Synonyms: L-histidinol dehydrogenase

Systematic Name: L-histidinol:NAD⁺ oxidoreductase

Unification Links: BRENDA:1.1.1.23, ENZYME:1.1.1.23, IUBMB-ExplorEnz:1.1.1.23

Reaction:
histidinol + 2 NAD⁺ + H₂O → L-histidine + 2 NADH + 3 H⁺

Enzymes and Genes:
histidinol dehydrogenase: hisD ( Escherichia coli K-12 substr. MG1655 )
histidinol dehydrogenase: HDH ( Brassica oleracea botrytis )
histidinol dehydrogenase: hisD ( Thermotoga maritima )

Summary:
Also oxidizes L-histidinal. The Neurospora enzyme also catalyses the reactions of EC 3.5.4.19 (phosphoribosyl-AMP cyclohydrolase) and EC 3.6.1.31 (phosphoribosyl-ATP diphosphatase).

Citations: [Adams54, Adams55, Yourno68, Loper68]

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References

Adams54: Adams E (1954). "The enzymatic synthesis of histidine from histidinol." J Biol Chem 209(2);829-46. PMID: 13192138

Adams55: Adams E (1955). "L-Histidinal, a biosynthetic precursor of histidine." J Biol Chem 217(1);325-44. PMID: 13271397

Loper68: Loper JC (1968). "Histidinol dehydrogenase from Salmonella typhimurium. Crystallization and composition studies." J Biol Chem 243(12);3264-72. PMID: 4872176

Yourno68: Yourno J, Ino I (1968). "Purification and crystallization of histidinol dehydrogenase from Salmonella typhimurium LT-2." J Biol Chem 243(12);3273-6. PMID: 4872177

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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