Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.1 -- Acting on the CH-OH group of donors → 1.1.1 -- With NAD(+) or NADP(+) as acceptor

Synonyms: T4HN reductase

Systematic Name: scytalone:NADP⁺ Δ⁵-oxidoreductase

Unification Links: BRENDA:1.1.1.252, ENZYME:1.1.1.252, IUBMB-ExplorEnz:1.1.1.252

Reaction:
scytalone + NADP⁺ = 1,3,6,8-naphthalenetetrol + NADPH + H⁺

Summary:
Reduces 1,3,6,8-tetrahydroxynaphthalene to scytalone and also reduces 1,3,8-trihydroxynaphthalene to vermelone.

Involved with EC 4.2.1.94 in the biosynthesis of melanin in pathogenic fungi.

Citations: [Vidal-Cros, 1994; Thompson, 1997]

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References

Thompson JE, Basarab GS, Andersson A, Lindqvist Y, Jordan DB (1997). "Trihydroxynaphthalene reductase from Magnaporthe grisea: realization of an active center inhibitor and elucidation of the kinetic mechanism." Biochemistry 36(7);1852-60. PMID: 9048570

Vidal-Cros A, Viviani F, Labesse G, Boccara M, Gaudry M (1994). "Polyhydroxynaphthalene reductase involved in melanin biosynthesis in Magnaporthe grisea. Purification, cDNA cloning and sequencing." Eur J Biochem 219(3);985-92. PMID: 8112349

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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