Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.1 -- Acting on the CH-OH group of donors → 1.1.1 -- With NAD(+) or NADP(+) as acceptor

Synonyms: MdH II, NAD(P)⁺-dependent malate dehyrogenase

Systematic Name: (S)-malate:NAD(P)⁺ oxidoreductase

Unification Links: BRENDA:1.1.1.299, ENZYME:1.1.1.299, IUBMB-ExplorEnz:1.1.1.299

Reaction:
(S)-malate + NAD(P)⁺ ↔ oxaloacetate + NAD(P)H + H⁺

Enzymes and Genes:
L-2-hydroxycarboxylate dehydrogenase: mdh ( Methanocaldococcus jannaschii )
NAD(P)-dependent malate dehydrogenase: mdh ( Methanothermobacter thermautotrophicus Delta H )

Summary:
There are several forms of malate dehydrogenases that differ by their use of substrate and cofactors. This enzyme, which was characterized from the methanogenic archaeon Methanothermobacter thermautotrophicus, catalyses only the reduction of oxaloacetate, and can use NADH and NADPH with similar specific activity [1]. cf. EC 1.1.1.37, malate dehydrogenase; EC 1.1.1.82, malate dehydrogenase (NADP⁺); and EC 1.1.5.4, malate dehydrogenase (quinone).

Citations: [Thompson98a]

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References

Thompson98a: Thompson H, Tersteegen A, Thauer RK, Hedderich R (1998). "Two malate dehydrogenases in Methanobacterium thermoautotrophicum." Arch Microbiol 170(1);38-42. PMID: 9639601

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Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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