Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.1 -- Acting on the CH-OH group of donors → 1.1.1 -- With NAD(+) or NADP(+) as acceptor

Synonyms: PhpC

Systematic Name: 2-hydroxyethylphosphonate:NAD⁺ oxidoreductase

Unification Links: BRENDA:1.1.1.309, ENZYME:1.1.1.309, IUBMB-ExplorEnz:1.1.1.309

Reaction:
2-hydroxyethylphosphonate + NAD⁺ ↔ phosphonoacetaldehyde + NADH + H⁺

Enzymes and Genes:
phophonoacetaldehyde reductase: phpC ( Kitasatospora phosalacinea )
phophonoacetaldehyde reductase: dhpG ( Streptomyces luridus )
phophonoacetaldehyde reductase: phpC ( Streptomyces viridochromogenes )
phosphonoacetaldehyde reductase: fomC ( Streptomyces fradiae )

Summary:
The enzyme from Streptomyces viridochromogenes catalyses a step in the biosynthesis of phosphinothricin tripeptide, the reduction of phosphonoacetaldehyde to 2-hydroxyethylphosphonate. The preferred cofactor is NADH, lower activity with NADPH [Blodgett07].

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References

Blodgett07: Blodgett JA, Thomas PM, Li G, Velasquez JE, van der Donk WA, Kelleher NL, Metcalf WW (2007). "Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide." Nat Chem Biol 3(8);480-5. PMID: 17632514

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Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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