Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.1 -- Acting on the CH-OH group of donors → 1.1.1 -- With NAD(+) or NADP(+) as acceptor

Synonyms: (2S)-3-sulfolactate dehydrogenase, SlcC

Systematic Name: (2S)-sulfolactate:NAD⁺ oxidoreductase

Unification Links: BRENDA:1.1.1.310, ENZYME:1.1.1.310, IUBMB-ExplorEnz:1.1.1.310

Reaction:
(2S)-3-sulfolactate + NAD⁺ ↔ 3-sulfopyruvate + NADH + H⁺

Enzymes and Genes:
S-sulfolactate dehydrogenase: slcC ( Chromohalobacter salexigens DSM 3043 )

Summary:
This enzyme, isolated from the bacterium Chromohalobacter salexigens DSM 3043, acts only on the (S)-enantiomer of 3-sulfolactate. Combined with EC 1.1.1.338, (2R)-3-sulfolactate dehydrogenase (NADP⁺), it provides a racemase system that converts (2S)-3-sulfolactate to (2R)-3-sulfolactate, which is degraded further by EC 4.4.1.24, (2R)-sulfolactate sulfo-lyase. Specific for NAD+.

Citations: [Denger10]

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References

Denger10: Denger K, Cook AM (2010). "Racemase activity effected by two dehydrogenases in sulfolactate degradation by Chromohalobacter salexigens: purification of (S)-sulfolactate dehydrogenase." Microbiology 156(Pt 3);967-74. PMID: 20007648

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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