Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.1 -- Acting on the CH-OH group of donors → 1.1.1 -- With NAD(+) or NADP(+) as acceptor

Systematic Name: (–)-secoisolariciresinol:NAD⁺ oxidoreductase

Unification Links: BRENDA:1.1.1.331, ENZYME:1.1.1.331, IUBMB-ExplorEnz:1.1.1.331

Reaction:
(-)-secoisolariciresinol + 2 NAD⁺ → (-)-matairesinol + 2 NADH + 2 H⁺

Enzymes and Genes:
(-)-secoisolariciresinol dehydrogenase: SDH ( Forsythia x intermedia )
(-)-secoisolariciresinol dehydrogenase: SDH ( Podophyllum peltatum )

Summary:
Isolated from the plants Forsythia x intermedia [Xia01] and Podophyllum peltatum [Xia01, Youn05, Moinuddin06]. An intermediate lactol is detected in vitro.

---

References

Moinuddin06: Moinuddin SG, Youn B, Bedgar DL, Costa MA, Helms GL, Kang C, Davin LB, Lewis NG (2006). "Secoisolariciresinol dehydrogenase: mode of catalysis and stereospecificity of hydride transfer in Podophyllum peltatum." Org Biomol Chem 4(5);808-16. PMID: 16493463

Xia01: Xia ZQ, Costa MA, Pelissier HC, Davin LB, Lewis NG (2001). "Secoisolariciresinol dehydrogenase purification, cloning, and functional expression. Implications for human health protection." J Biol Chem 276(16);12614-23. PMID: 11278426

Youn05: Youn B, Moinuddin SG, Davin LB, Lewis NG, Kang C (2005). "Crystal structures of apo-form and binary/ternary complexes of Podophyllum secoisolariciresinol dehydrogenase, an enzyme involved in formation of health-protecting and plant defense lignans." J Biol Chem 280(13);12917-26. PMID: 15653677

---

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
Page generated by Pathway Tools version 28.0 (software by SRI International) on Sat Apr 27, 2024, BIOCYC17A.